Biomaterials, Год журнала: 2025, Номер unknown, С. 123130 - 123130
Опубликована: Янв. 1, 2025
Язык: Английский
Materials Today Chemistry, Год журнала: 2023, Номер 34, С. 101818 - 101818
Опубликована: Ноя. 18, 2023
Язык: Английский
Процитировано
56
Gels, Год журнала: 2024, Номер 10(4), С. 216 - 216
Опубликована: Март 22, 2024
Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, structural similarity the extracellular matrix. Recent chemical advancements have bolstered versatility, facilitating integration molecules guiding cellular activities enabling controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity network imperfections, which adversely affect mechanical properties, diffusion rates, biological activity. In response these challenges, hybrid emerged, aiming enhance strength, drug release efficiency, therapeutic effectiveness. These hydrogels, featuring improved formulations, are tailored for tissue regeneration across both soft hard tissues. The scientific community has increasingly recognized versatile characteristics particularly sector. This comprehensive review delves into recent hydrogel systems, covering diverse types, modification strategies, nano/microstructures. discussion includes innovative fabrication techniques click reactions, 3D printing, photopatterning alongside elucidation mechanisms bioactive molecules. By addressing underscores envisages a promising future various domains field.
Язык: Английский
Процитировано
38
Bioprinting, Год журнала: 2024, Номер 38, С. e00331 - e00331
Опубликована: Янв. 28, 2024
Язык: Английский
Процитировано
31
EnergyChem, Год журнала: 2024, Номер 6(3), С. 100123 - 100123
Опубликована: Март 19, 2024
Язык: Английский
Процитировано
26
Advanced Science, Год журнала: 2024, Номер 11(22)
Опубликована: Апрель 11, 2024
Abstract The inflammatory response is a key factor affecting tissue regeneration. Inspired by the immunomodulatory role of spermidine, an injectable double network hydrogel functionalized with spermidine (DN‐SPD) developed, where first and second networks are formed dynamic imine bonds non‐dynamic photo‐crosslinked respectively. single before photo‐crosslinking exhibits excellent injectability thus can be printed in situ to form hydrogels. DN‐SPD has demonstrated desirable mechanical properties adhesion. More importantly, “operando” comparison hydrogels loaded or diethylenetriamine (DETA), sham molecule resembling shown similar physical properties, but quite different biological functions. Specifically, outcomes 3 sets vivo animal experiments demonstrate that not only reduce inflammation caused implanted exogenous biomaterials reactive oxygen species also promote polarization macrophages toward regenerative M2 phenotype, DN‐DETA hydrogel. Moreover, immunoregulation translate into faster more natural healing both acute wounds diabetic wounds. Hence, local administration affords simple elegant approach attenuate foreign body reactions induced treat chronic refractory
Язык: Английский
Процитировано
22
Advanced Materials, Год журнала: 2024, Номер 36(23)
Опубликована: Фев. 23, 2024
Polysaccharides constitute over 90% of the carbohydrate mass in nature, which makes them a promising feedstock for manufacturing sustainable materials. Polysaccharide particles (PSPs) are used as effective scavengers, carriers chemical and biological cargos, building blocks fabrication macroscopic The biocompatibility degradability PSPs advantageous their uses biomaterials with more environmental friendliness. This review highlights progresses PSP applications advanced functional materials, by describing extraction, preparation, surface functionalization variety groups, polymers, nanoparticles, biologically active species. also outlines PSP-derived well soft robotics, sensing, scavenging, water harvesting, drug delivery, bioengineering. paper is concluded an outlook providing perspectives development
Язык: Английский
Процитировано
19
Exploration, Год журнала: 2024, Номер unknown
Опубликована: Апрель 11, 2024
Decellularized extracellular matrix (dECM) offers a three-dimensional, non-immunogenic scaffold, enriched with bioactive components, making it suitable candidate for tissue regeneration. Although dECM-based scaffolds have been successfully implemented in preclinical and clinical settings within engineering regenerative medicine, the mechanisms of remodeling functional restoration are not fully understood. This review critically assesses state-of-the-art dECM scaffolds, including decellularization techniques various tissues, quality control cross-linking. It highlights properties components their latest applications multiorgan biomedicine. Additionally, addresses current challenges limitations decellularized perspectives on future directions field.
Язык: Английский
Процитировано
19
Biomacromolecules, Год журнала: 2024, Номер 25(2), С. 564 - 589
Опубликована: Янв. 4, 2024
As a biodegradable and biocompatible protein derived from collagen, gelatin has been extensively exploited as fundamental component of biological scaffolds drug delivery systems for precise medicine. The easily engineered holds great promise in formulating various to protect enhance the efficacy drugs improving safety effectiveness numerous pharmaceuticals. remarkable biocompatibility adjustable mechanical properties permit construction active 3D accelerate regeneration injured tissues organs. In this Review, we delve into diverse strategies fabricating functionalizing gelatin-based structures, which are applicable gene well tissue engineering. We emphasized advantages derivatives, including methacryloyl gelatin, polyethylene glycol-modified thiolated alendronate-modified gelatin. These derivatives exhibit excellent physicochemical properties, allowing fabrication tailor-made structures biomedical applications. Additionally, explored latest developments modulation their by combining additive materials manufacturing platforms, outlining design multifunctional micro-, nano-, macrostructures. While discussing current limitations, also addressed challenges that need be overcome clinical translation, high costs, limited application scenarios, potential immunogenicity. This Review provides insight how structural chemical engineering can leveraged pave way significant advancements applications improvement patient outcomes.
Язык: Английский
Процитировано
18
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 1189 - 1204
Опубликована: Фев. 1, 2024
Abstract: Tissue engineering holds great potential for tissue repair and rejuvenation. Plant-derived exosome-like nanoparticles (ELNs) have recently emerged as a promising avenue in engineering. However, there is an urgent need to understand how plant ELNs can be therapeutically applied clinical disease management, especially regeneration. In this review, we comprehensively examine the properties, characteristics, isolation techniques of ELNs. We also discuss their impact on immune system, compatibility with human body, role To ensure suitability engineering, explore various modification strategies. Additionally, provide insights into progress commercialization industrial perspectives This review aims highlight regenerative medicine by exploring current research landscape key findings. Keywords: plant, nanoparticles, nanomedicine, cartilage, wound, bone
Язык: Английский
Процитировано
16
ACS Omega, Год журнала: 2025, Номер 10(1), С. 1207 - 1225
Опубликована: Янв. 3, 2025
Manufacturing bioactive materials for drug delivery involves developing that interact with biological tissues to release drugs in a controlled and targeted manner. The goal is optimize therapeutic efficacy reduce side effects by combining knowledge from engineering, biology, pharmacology. This study presents detailed bibliometric analysis, exploring the keywords "manufacturing," "bioactive materials," "drug delivery" identify highlight significant advancements field. From Web of Science, 36,504 articles were analyzed, 171 selected deeper identifying key journals, countries, institutions, authors. results field's interdisciplinary nature, grouped into four main themes, including regenerative medicine, scaffolds, three-dimensional (3D) printing, glass, tissue engineering. Future research this area will focus on more effective precise systems using technologies like 3D printing nanotechnology enhance customization control release, aiming efficient therapies.
Язык: Английский
Процитировано
3