Engineered protein-based materials for tissue repair: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
303, С. 140674 - 140674
Опубликована: Фев. 3, 2025
Язык: Английский
An injectable, self-healing, anti-infective, and anti-inflammatory novel glycyrrhizic acid hydrogel for promoting acute wound healing and regeneration
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 10, 2025
Bacterial
infection,
a
complex
wound
microenvironment,
and
persistent
inflammatory
response
in
acute
wounds
can
result
delayed
healing
abnormal
scar
formation,
thereby
compromising
the
normal
function
aesthetic
appearance
of
skin
tissue.
This
issue
represents
one
most
challenging
problems
clinical
practice.
study
aims
to
develop
hydrogel
dressing
specifically
designed
for
treatment
wounds,
providing
immediate
effective
protection
affected
areas.
innovation
seeks
offer
novel
advanced
solution
management
wounds.
In
this
study,
composite
scaffold
was
synthesized
through
reaction
between
oxidized
glycyrrhizic
acid
carboxymethyl
chitosan
Schiff
base.
The
material
properties
were
systematically
characterized,
its
biocompatibility
antibacterial
efficacy
rigorously
evaluated.
A
rat
model
established
compare
multiple
groups,
assessing
impact
on
microenvironment
repair.
results
demonstrated
that
OGA-CMCS
exhibited
excellent
injectability,
biocompatibility,
properties.
It
capable
enhancing
which
turn
influenced
polarization
macrophages
from
M1
M2
phenotype,
mitigating
response,
promoting
angiogenesis
granulation
tissue
regeneration,
accelerating
healing.
successfully
developed
glycyrrhizin-based
dressing,
not
only
introduces
innovative
approaches
emergency
surface
defects
but
also
provides
an
experimental
foundation.
is
anticipated
contribute
significantly
addressing
relevant
challenges.
Язык: Английский
Exosome-Loaded Tannic Acid–Thioctic Acid Hydrogel Enhances Wound Healing in Coagulation Disorders
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101496 - 101496
Опубликована: Янв. 25, 2025
Язык: Английский
Immunomodulatory Bioadhesive Technologies
Biomaterials,
Год журнала:
2025,
Номер
unknown, С. 123274 - 123274
Опубликована: Март 1, 2025
Bioadhesives
have
found
significant
use
in
medicine
and
engineering,
particularly
for
wound
care,
tissue
surgical
applications.
Compared
to
traditional
closure
methods
such
as
sutures
staples,
bioadhesives
offer
advantages,
including
reduced
damage,
enhanced
healing,
ease
of
implementation.
Recent
progress
highlights
the
synergy
immunoengineering
strategies,
leading
immunomodulatory
capable
modulating
immune
responses
at
local
sites
where
are
applied.
They
foster
favorable
therapeutic
outcomes
inflammation
wounds
implants
or
improve
cancer
therapy
efficacy.
The
dual
functionalities
bioadhesion
immunomodulation
benefit
management,
regeneration,
implantable
medical
devices,
post-surgical
management.
This
review
delves
into
interplay
between
immunomodulation,
highlighting
mechanobiological
coupling
involved.
Key
areas
focus
include
modulation
through
chemical
physical
well
application
these
healing
treatment.
Discussed
remaining
challenges
achieving
long-term
stability
effectiveness,
necessitating
further
research
fully
harness
clinical
potential
bioadhesives.
Язык: Английский
Nanoparticle-Driven Tendon Repair: Role of Vasoactive Intestinal Peptide in Immune Modulation and Stem Cell Enhancement
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Tendon
repair
remains
challenging
owing
to
the
limited
capacity
for
endogenous
repair.
Vasoactive
intestinal
peptide
(VIP)
promotes
bone
tissue
regeneration;
however,
its
role
in
tendon
unclear.
In
present
study,
we
demonstrated
that
VIP
stimulated
M2
polarization
of
macrophages
and
facilitated
regeneration
by
regulating
immune
homeostasis
maintaining
function
stem/progenitor
cells
(TSPCs).
Additionally,
established
GelMa-loaded
VIP@PLGA@ZIF-8
(VPZ)
nanoparticles
(VPZG)
enable
sustained
localized
release
at
site
patellar
injury
SD
rats.
The
results
vitro
experiments
VPZG
regulated
macrophage
downregulating
NF-κB
axis.
also
promoted
efferocytosis
suppressed
proinflammatory
factors.
enhanced
tenogenic
differentiation
TSPCs
when
cocultured
with
macrophages.
vivo,
implanted
injury,
where
it
released
sustainably
slowly
promote
regeneration.
This
effect
was
achieved
through
downregulation
expression
levels
various
inflammatory
factors,
as
well
regulation
local
homeostasis.
conclusion,
our
enhancing
TSPC
function.
These
findings
suggest
is
a
promising
avenue
clinical
improvement
treatment.
Язык: Английский
Deciphering immune dynamics in atherosclerosis: Inflammatory mediators as biomarkers and therapeutic target
European Journal of Clinical Investigation,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Atherosclerosis,
one
of
the
main
causes
cardiovascular
disease,
is
driven
by
complex
interactions
between
lipid
metabolism
and
immune
mechanisms
in
vascular
system.
Regulatory
molecules,
particularly
protein
fragments
derived
from
cytokines,
chemokines
other
immune-related
proteins,
play
a
central
role
modulating
inflammation
responses
atherosclerotic
plaques.
Recent
advances
peptidomics
have
revealed
dual
system-derived
peptides
as
indicators
effectors
disease
(ASCVD).
Certain
subsets
cells,
such
pro-inflammatory
monocytes
regulatory
T
contribute
to
this
peptide-mediated
regulation.
New
findings
suggest
that
these
may
serve
diagnostic
biomarkers
therapeutic
targets
atherosclerosis.
This
review
highlights
translational
relevance
immune-mediated
ASCVD
emphasizes
their
potential.
By
integrating
with
immunology
research,
new
framework
for
understanding
targeting
atherosclerosis
proposed,
opening
avenues
precision
medicine
care.
Язык: Английский