Zinc or/and Vitamin E Supplementation Mitigates Oxidative Stress, Neuroinflammation, Neurochemical Changes and Behavioural Deficits in Male Wistar Rats Exposed to Bonny Light Crude Oil DOI Creative Commons
Oluwafunmbi Ebenezer Ogunmiluyi,

A Naiho,

Victor Emojevwe

и другие.

Journal of Toxicology, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Background: Crude oil, a major key economic driver in developing countries, is also of environmental concern, linked to neurotoxicity and behavioural problems. Despite the known neurotoxic effects crude oil potential benefits zinc vitamin E, there paucity research specifically addressing their combined efficacy mitigating neurochemical changes deficits induced by oil. Current studies have largely focussed on individual these supplements different contexts, but synergistic exposure model remains underexplored. This study investigated E neurobehavioural alterations male Wistar rats fed with Bonny light (BLCO)‐contaminated diet. Methods: Thirty (30) (160 ± 10 g) were assigned into five groups ( n = 6). Group 1 received standard rat feed, 2 was exposed BLCO (0.1 mL/g feed) for 3 weeks, 3–5 treated (50 mg/kg/day), (400 IU/kg), or both [vitamin IU/kg) + mg/kg/day)], respectively week after weeks. Locomotive, anxiolytic, depressive‐like behaviours spatial memory assessed using open‐field test, elevated plus maze, forced swim test Y‐maze. Rats sacrificed brain samples collected biochemical assays at end tests. Results: Zinc supplementation (individually combined) significantly increased total antioxidant capacity superoxide dismutase (SOD) activity, reduced inflammatory markers (TNF‐alpha) lipid peroxidation, normalized neurotransmitter levels improved performance. Conclusion: Treatment Zn and/or reverses BLCO‐induced via modulation oxidative stress, inflammation neurotransmitters.

Язык: Английский

Effect of N-Acetyl Cysteine as an Adjuvant Treatment in Alzheimer’s Disease DOI Creative Commons
Sarah Monserrat Lomelí Martínez, Fermín Paul Pacheco‐Moisés, Oscar Kurt Bitzer-Quintero

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(2), С. 164 - 164

Опубликована: Фев. 7, 2025

Oxidative stress levels are exacerbated in Alzheimer's disease (AD). This phenomenon feeds back into the overactivation of oxidase enzymes, mitochondrial dysfunction, and formation advanced glycation end-products (AGEs), with stimulation their receptors (RAGE). These factors stimulate Aβ peptide aggregation tau hyperphosphorylation through multiple pathways, which addressed this paper. The aim study was to evaluate regulatory effect N-acetyl cysteine (NAC) on oxidant/antioxidant balance as an adjuvant treatment patients AD. results obtained showed that NAC supplementation produced improved cognitive performance, decreased oxidative markers, lowered activities increased antioxidant responses, attenuated inflammatory apoptotic markers. Moreover, reversed AGEs-RAGE formation, oligomerization, reduced phosphorylation tau, thereby halting neurofibrillary tangles progression

Язык: Английский

Процитировано

0
Zinc or/and Vitamin E Supplementation Mitigates Oxidative Stress, Neuroinflammation, Neurochemical Changes and Behavioural Deficits in Male Wistar Rats Exposed to Bonny Light Crude Oil DOI Creative Commons
Oluwafunmbi Ebenezer Ogunmiluyi,

A Naiho,

Victor Emojevwe

и другие.

Journal of Toxicology, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Background: Crude oil, a major key economic driver in developing countries, is also of environmental concern, linked to neurotoxicity and behavioural problems. Despite the known neurotoxic effects crude oil potential benefits zinc vitamin E, there paucity research specifically addressing their combined efficacy mitigating neurochemical changes deficits induced by oil. Current studies have largely focussed on individual these supplements different contexts, but synergistic exposure model remains underexplored. This study investigated E neurobehavioural alterations male Wistar rats fed with Bonny light (BLCO)‐contaminated diet. Methods: Thirty (30) (160 ± 10 g) were assigned into five groups ( n = 6). Group 1 received standard rat feed, 2 was exposed BLCO (0.1 mL/g feed) for 3 weeks, 3–5 treated (50 mg/kg/day), (400 IU/kg), or both [vitamin IU/kg) + mg/kg/day)], respectively week after weeks. Locomotive, anxiolytic, depressive‐like behaviours spatial memory assessed using open‐field test, elevated plus maze, forced swim test Y‐maze. Rats sacrificed brain samples collected biochemical assays at end tests. Results: Zinc supplementation (individually combined) significantly increased total antioxidant capacity superoxide dismutase (SOD) activity, reduced inflammatory markers (TNF‐alpha) lipid peroxidation, normalized neurotransmitter levels improved performance. Conclusion: Treatment Zn and/or reverses BLCO‐induced via modulation oxidative stress, inflammation neurotransmitters.

Язык: Английский

Процитировано

0