Galangin exosomes induce cell apoptosis through miR-10b/P53 axis in gastric cancer DOI Creative Commons
Qirong Li, Yongsheng Zhang, Bin Shi

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 15, 2025

Galangin is an extract of traditional Chinese medicine with anti-cancer effect. Exosomes (Exo) contain RNA, peptides, or proteins and communicate between cells through a bio-genesis pathway. In the present study, Gastric cancer (GC) cell exosomes containing galangin were obtained. MicroRNAs (miRNAs) in (galangin-Exo) screened by RNA-seq. GC treated galangin-Exo changes proliferation analyzed. Besides, mouse model was established to verify effect vivo. The results showed that inhibited growth AGS BGC823 cells. Additionally, RNA-seq data miR-10b-5p differentially expressed exosomes. reduced expression which increased P53 induced apoptosis vivo confirmed can inhibit tumor delivering galangin. conclusion, our suggest have on be used as potential therapeutic strategy.

Язык: Английский

Galangin exosomes induce cell apoptosis through miR-10b/P53 axis in gastric cancer DOI Creative Commons
Qirong Li, Yongsheng Zhang, Bin Shi

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 15, 2025

Galangin is an extract of traditional Chinese medicine with anti-cancer effect. Exosomes (Exo) contain RNA, peptides, or proteins and communicate between cells through a bio-genesis pathway. In the present study, Gastric cancer (GC) cell exosomes containing galangin were obtained. MicroRNAs (miRNAs) in (galangin-Exo) screened by RNA-seq. GC treated galangin-Exo changes proliferation analyzed. Besides, mouse model was established to verify effect vivo. The results showed that inhibited growth AGS BGC823 cells. Additionally, RNA-seq data miR-10b-5p differentially expressed exosomes. reduced expression which increased P53 induced apoptosis vivo confirmed can inhibit tumor delivering galangin. conclusion, our suggest have on be used as potential therapeutic strategy.

Язык: Английский

Процитировано

0