Antimicrobial Metabolites of Caucasian Medicinal Plants as Alternatives to Antibiotics

Antibiotics, Год журнала: 2024, Номер 13(6), С. 487 - 487

Опубликована: Май 24, 2024

This review explores the potential of antimicrobial metabolites derived from Caucasian medicinal plants as alternatives to conventional antibiotics. With rise antibiotic resistance posing a global health threat, there is pressing need investigate alternative sources agents. have traditionally been used for their therapeutic properties, and recent research has highlighted compounds. Representatives 15 families plant extracts (24 species) explored efficacy against these pathogens. The effect on Gram-positive Gram-negative bacteria fungi discussed in this paper. By harnessing bioactive present plants, study aims contribute development new treatments that can effectively combat bacterial infections while minimizing risk emergence. Herein we discuss following classes compounds exhibiting activity: phenolic compounds, flavonoids, tannins, terpenes, saponins, alkaloids, sulfur-containing Allium species. discusses pharmacological properties selected extraction characterization metabolites, mechanisms action antibacterial antifungal applications clinical settings. Additionally, challenges future directions are addressed.

Язык: Английский

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Plant Polyphenols as Heart’s Best Friends: From Health Properties, to Cellular Effects, to Molecular Mechanisms of Action

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 915 - 915

Опубликована: Янв. 22, 2025

Polyphenols are micronutrients found in fruits, vegetables, tea, coffee, cocoa, medicinal herbs, fish, crustaceans, and algae. They can also be synthesized using recombinant microorganisms. Interest plant-derived natural compounds has grown due to their potential therapeutic effects with minimal side effects. This is particularly important as the aging population faces increasing rates of chronic diseases such cancer, diabetes, arthritis, cardiovascular, neurological disorders. Studies have highlighted polyphenols’ capacity reduce risk factors linked onset illnesses. narrative review discusses polyphenol families metabolism, cardioprotective polyphenols evidenced from vitro studies, well vivo on different animal models cardiac disease. study explores molecular mechanisms underlying these benefits. Current research suggests that may protect against ischemia, hypertension, hypertrophy, heart failure, myocardial injury through complex mechanisms, including epigenetic genomic modulation. However, further studies under nutritionally physiologically relevant conditions, untargeted multigenomic approaches, needed more comprehensively elucidate firmly prove polyphenols.

Язык: Английский

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Characterization of Azorean Plant Leaves for Sustainable Valorization and Future Advanced Applications in the Food, Cosmetic, and Pharmaceutical Industries

Antioxidants, Год журнала: 2024, Номер 13(3), С. 325 - 325

Опубликована: Март 6, 2024

The historical use of plants as sources natural compounds has persisted over time. Increasing the intake bioactive substances shows significant potential for promoting overall well-being and health. This study delves into pigments, phenolic composition, profile, along with antioxidant properties, leaf extracts rich in bioactives from Azores region, contributing to sustainable primary food production. Analyses encompassed chlorophylls, carotenoids, total phenols, ortho-diphenols, flavonoids, well capacity assessment, polyphenolic profiling, quantification. Psidium guajava L. Smallanthus sonchifolius (Poepp.) H.Rob. exhibited elevated chlorophyll content, while Colocasia esculenta (L.) Schott displayed highest carotenoid levels. Annona cherimola Mill., Eriobotrya japonica (Thunb.) Lindl, demonstrated pronounced flavonoids. These findings align heightened capacity. HPLC–DAD (high-performance liquid chromatography diode-array detection) characterization unveiled hydroxycinnamic acids E. Ipomea batatas Lam. compared A. C. increased flavone content. Among quantified compounds, flavonols were ones that predominantly contribution these leaves. research highlights Azorean plants’ potential, fostering product development better

Язык: Английский

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A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12091 - 12091

Опубликована: Ноя. 11, 2024

The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize existing research quercetin's potential health benefits, therapeutic properties, effectiveness in disease prevention treatment. In addition evaluating for drug development with fewer side effects lower toxicity, type attempts collect scientific evidence addressing roles as an antioxidant, anti-inflammatory, antibacterial, anticancer agent. first part, we analyze various flavonoid compounds, focusing their chemical structure, classification, natural sources. We highlight most recent biological activities reported literature. Among these pay special attention quercetin, detailing its physicochemical process biosynthesis plants. also present sources emphasize such antioxidant anti-inflammatory effects. Additionally, discuss methods enhance bioavailability, analyzing latest effective delivery systems based quercetin.

Язык: Английский

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The multifaceted role of quercetin derived from its mitochondrial mechanism

Molecular and Cellular Biochemistry, Год журнала: 2023, Номер 479(8), С. 1985 - 1997

Опубликована: Сен. 1, 2023

Язык: Английский

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Critical review on plant-derived quorum sensing signaling inhibitors in pseudomonas aeruginosa

Bioorganic Chemistry, Год журнала: 2024, Номер 151, С. 107649 - 107649

Опубликована: Июль 15, 2024

Язык: Английский

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Potential Anti-ulcerogenic Effect of Troxerutin in Ethanol-induced Gastric Lesions in Mice: Anti-inflammatory and Antioxidant Mechanisms and Possible Action Pathways

Revista Brasileira de Farmacognosia, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Systems Biology Study on Bioactive Compounds

Опубликована: Янв. 1, 2025

Язык: Английский

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Computational biology of antibody epitope, tunnels and pores analysis of protein glutathione S-transferase P, and quantum mechanics

Biochemistry and Biophysics Reports, Год журнала: 2023, Номер 36, С. 101581 - 101581

Опубликована: Ноя. 16, 2023

Different tissues of various plants contain allelochemicals such as phenolics, flavonoids, etc., which exhibit antioxidants and protect the from harmful infections. The widespread group plant in ecosystem is phenolic compounds. They are substances composed an aromatic hydrocarbon a hydroxyl group. 3-Hydroxyflavone skeleton flavonol has substitution. A comparison experimental calculated data FT-IR Raman was studied for vibrational assessment these allelochemicals. PES scan molecular geometry analysis done conformation ligand. docked with three proteins Homo sapiens Prothrombin 622 amino acids synthesized liver, human neutrophils found within intracellular granules 467 acids, Glutathione S-transferase P produced exogenous xenobiotics 210 acids. active site residues by using (1A2C), Neutrophil collagenase (1A86), P(18 GS) protein ligand 3-Hydroxyflavone, fair binding affinity (18 GS). MOLE online server web interface's ability to see analyze tunnels pores allows simple, interaction bio-macromolecule investigation. automatic transmembrane channel calculation on generates quickest list ligands transport tunnel identification. Pore-forming (PFPs) recognized crucial agents immunity infection. target membranes opening channels through them. ElliPro thought be potentially effective method identifying antibody epitopes antigens. Molecular dynamics result general time-dependent structural deviation/degree similarity among structures that trajectory records. epitope technique sought examine effectiveness its tool linear discontinuous known antibodies 18 GS complexes find scores.

Язык: Английский

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Intestinal absorption mechanism and nutritional synergy promotion strategy of dietary flavonoids: transintestinal epithelial pathway mediated by intestinal transport proteins

Critical Reviews in Food Science and Nutrition, Год журнала: 2024, Номер unknown, С. 1 - 14

Опубликована: Авг. 1, 2024

Dietary flavonoids exhibit a variety of physiological functions in regulating glucose and lipid metabolism, improving cardiovascular function, enhancing stress resistance. However, poor intestinal absorption limits their health benefits. Previous studies on the efficiency have focused targeted release, enhanced gastrointestinal stability prolonged retention time digestive tract. But less attention has been paid to promoting uptake transport by epithelial cells through modulation transporter protein-mediated pathways. Interestingly, some dietary nutrients found modulate expression or function proteins, thereby synergistically antagonistically affecting flavonoid absorption. Therefore, this paper proposed an innovative regulatory strategy known as "intestinal pathway" promote flavonoids. The mechanism epithelium, mediated was summarized. functional differences between efflux transporters during trans-intestinal cellular were discussed. Finally, from perspective nutritional synergy promotion absorption, feasibility expression/function proteins emphasized. This review provides new developing precise nutrient combinations for efficient

Язык: Английский

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