Oral supplementation of curcumin-encapsulated chitosan nanoconjugates as an innovative strategy for mitigating nickel-mediated hepatorenal toxicity in rats

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Abstract Nickel pollution adversely affects human health and causes various disorders, mainly hepatic renal dysfunction. The present work focused on a comparative evaluation of the pure form curcumin (CU) with curcumin-encapsulated chitosan nanoconjugates (CS/CU NCs), mitigation delirious effects Ni hepatorenal tissue. Forty-two male rats were allocated into 6 groups (n = 7 for each) as follows: (1) control, (2) CU, (3) CS/CU NCs, (4) Ni, (5) + (6) NCs. After 30 days, blood tissue (liver kidneys) collected to measure biomarkers, oxidant/antioxidant balance, inflammatory gene expression, liver kidney histopathology, immunohistochemistry. Results revealed disruption functions, oxidative stress, markers at biochemical molecular levels associated severe histopathological alterations abnormal immunohistochemical expression caspase-3 cyclooxygenase-2. On contrary, treatment Ni-intoxicated NCs markedly mitigated adverse effect via regulation inflammatory, apoptotic markers. study provides novel nanoformulation using CS NPs encapsulation that selectively targets injured cells improves beneficial CU enhancing antioxidant activity regulating both

Язык: Английский

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Physalis peruviana calyces extract ameliorate oxidative stress, inflammation, and immune loss in rats-exposed to hexaflumuron

BMC Complementary Medicine and Therapies, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 22, 2025

Abstract Background Hexaflumuron (HFM), a common pesticide, can disrupt the immune system and cause oxidative stress. This study investigated potential of Physalis peruviana L. calyces extract (PP) to counteract these effects in rats. Methods Rats were divided into 6 groups including control, PP-treated, HFM-exposed, co-treated (HFM + PP) groups. Immune function, antioxidant activity, organ damage assessed. Furthermore, UPLC-MS/MS analysis identified bioactive compounds PP extract. Results HFM exposure suppressed responses caused damage. Notably, co-administration with reversed effects, indicating its ability reduce stress protect system. ethanolic revealed richness various health-promoting metabolites, acyl sucrose sugar, withanolides, flavonoids, which may provide valuable insight underlying mechanisms PP’s protective against toxicity. Conclusions provides novel insights P. as natural agent harmful exposure. These findings have significant implications for developing effective strategies mitigate pesticide-induced toxicity promote human health.

Язык: Английский

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Acetamiprid Induces Cardiotoxicity in Rats by Dysregulating α7 nAChR and its Downstream Targets: the Ameliorative Role of Resveratrol

Food and Chemical Toxicology, Год журнала: 2024, Номер 191, С. 114892 - 114892

Опубликована: Июль 26, 2024

Язык: Английский

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Behavioral, biochemical, histopathological evaluation and gene expression of brain injury induced by nanoceria injected intranasal or intraperitoneal in mice

Toxicology Research, Год журнала: 2024, Номер 13(4)

Опубликована: Июль 1, 2024

Nanotechnology has shown a remarkable progress nevertheless, there is growing concern about probable neurotoxic and neurodegenerative effects due to NPs exposure. Various toxicological epidemiological studies reported that the brain main target for ultrafine particles. Brain inflammation considered as possible mechanism can participate effects. Whether nanoparticles (NPs) may produce neurotoxicity promote largely unstudied. The present study was done investigate whether intranasal intra-peritoneal exposure cerium oxide (CeO2NPs, nanoceria (NC)) could cause changes in tissue through conducting some behavioral tests, biochemical evaluation, histopathological examinations of hippocampus gene expressions. Fifteen mice were separated into 3 equal groups. In group (I) "control group", received distilled water orally kept control group. Mice (II) "NC I/P group" injected i.p with at dose 40 mg/kg b.wt, twice weekly weeks. (III) I/N intranasally (40 b.wt), Exposure nanceria resulted oxidative damage tissue, significant increase malondialdehyde (MDA) acetylcholinestrase (AchE) levels, decrease reduced glutathione (GSH) concentration, upregulation apoptosis-related genes (c-Jun: c-Jun N-terminal kinases (JNKs), c-Fos: Fos protooncogene, AP-1 transcription factor subunit, c-Myc: c-myelocytomatosis oncogene product or MYC bHLH factor), locomotor cognitive impairment but effect more obvious when adminstred intraperitoneally. Nanoceria intraperitoneally than those intranasal.

Язык: Английский

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Epigallocatechin gallate-rich fraction alleviates histamine-induced neurotoxicity in rats via inactivating caspase-3/JNK signaling pathways

Food and Chemical Toxicology, Год журнала: 2024, Номер 193, С. 115021 - 115021

Опубликована: Сен. 23, 2024

Язык: Английский

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Phytochemical profiling, antioxidant and nephroprotective activities of Ziziphus lotus Lam. leaf extract in paracetamol-induced renal toxicity in rats and molecular docking analysis

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 25, 2024

Ziziphus lotus Lam. is a medicinal plant that used mostly in Nigeria and parts of Africa for treating many diseases. The study was aimed at assessing the phytoconstituents, evaluating antioxidant nephroprotective activities against paracetamol-induced renal toxicity rats molecular docking analysis leaf extract. Liquid-liquid partitioning carried out most active fraction while column chromatography isolation bioactive compounds analyzed by GC-MS. Total phenolic total flavonoid contents were determined using standard methods, activity DPPH (2-2-diphenyl-1-picrylhydrazyl) ABTS (2,2’azinobis (3ethyl-benzothiazoline-6sulfonic acid) scavenging assays evaluated various extract doses rats. Molecular studies AutoDock Vina software. GC-MS profiling revealed presence 18 with five showing strongest activities. predicted potential effects. results further content 408.12 mg GAE/g 88.01 QE/g. It also showed significant (p < 0.05) radical concentrations 0 to 800 µg/mL. There abnormal increases biochemical parameters before treatment rats, these reduced significantly on administration Our Z. possessed reversed kidney toxicity, thus, justifying its uses as an ethnomedicinal remedy problems.

Язык: Английский

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Betaine alleviates methomyl-triggered oxidative stress-mediated cardiopulmonary inflammation in rats through iNOS/Cox2 and Nrf2/HO1/Keap1 signaling pathway

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 495, С. 117223 - 117223

Опубликована: Дек. 31, 2024

Язык: Английский

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Evaluation of chitosan NPs loaded with Camellia sinensis (L.) Kuntze extract for targeted therapy against Pseudomonas aeruginosa-associated SKOV3 ovarian cancer cells

Journal of Pharmacy and Allied Medicine, Год журнала: 2024, Номер 2(2), С. 61 - 72

Опубликована: Дек. 27, 2024

Язык: Английский

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