Betaine: A Comprehensive Review on Dietary Sources, Health Benefits, Mechanisms of Action, and Application

Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 104993 - 104993

Опубликована: Апрель 1, 2025

Язык: Английский

“Polyethylene Terephthalate Nanoplastics Caused Hepatotoxicity in Mice Can be Prevented by Betaine: Molecular and Immunohistochemical Insights”

Journal of Biochemical and Molecular Toxicology, Год журнала: 2024, Номер 38(12)

Опубликована: Дек. 1, 2024

Polyethylene terephthalate nanoplastics (PET-NPs) are one of the most frequently distributed in daily life. Betaine is thought to be a promising hepatoprotective agent. The current investigation focused on whether orally administered PET-NPs caused hepatotoxicity and ameliorative effect betaine. Forty adult male Swiss albino mice were randomly split into four groups: group I control, II betaine (1000 mg/kg I/P), III (200 orally), IV plus at doses similar II& respectively. After 30 days, blood sample collected then animals euthanized liver specimens dissected out for biochemical histopathological examination. induced significant elevation alanine aminotransferase (ALT), aspartate (AST), malondialdehyde (MDA), as well an increase inflammatory genes proto-oncogene (c-FOS) cyclooxygenase 2 (COX2) (p ≤ 0.05), with substantial decrease glutathione (GSH) 0.05). Furthermore, level analysis alterations hepatic tissue architecture vascular dilatation congestion hepatocytes degeneration, bile duct epithelial hyperplasia cell infiltrations While immunohistochemistry, trigger positive tumor necrosis factor-alpha (TNF-α) nuclear factor-kappa B (NF-ҠB) expression comparison control. Meanwhile, treatment reduced deleterious effects PET-NPs. To summarize, may cause mice, belief that could mitigate detrimental impact.

Язык: Английский

Betaine alleviates methomyl-triggered oxidative stress-mediated cardiopulmonary inflammation in rats through iNOS/Cox2 and Nrf2/HO1/Keap1 signaling pathway

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 495, С. 117223 - 117223

Опубликована: Дек. 31, 2024

Язык: Английский