Advances in Traditional Medicine, Год журнала: 2023, Номер 24(2), С. 617 - 631
Опубликована: Дек. 12, 2023
Язык: Английский
Drug Development Research, Год журнала: 2025, Номер 86(1)
Опубликована: Янв. 5, 2025
ABSTRACT The central nervous system is affected by multiple sclerosis (MS), a chronic autoimmune illness characterized axonal destruction, demyelination, and inflammation. This article summarizes the state of field, highlighting its complexity significant influence on people's quality life. research employs network pharmacological approach, integrating systems biology, bioinformatics, pharmacology to identify biomarkers associated with MS. Utilizing Nelumbo Nucifera (Lotus) seeds, study involves toxicity assessments, biomolecule screening, target prediction. Advanced computational methodologies are employed, including molecular docking dynamic simulations, assess potential therapeutic interactions. Biomolecule screening identifies eight active compounds from Lotus Anonaine Liriodenine. Target prediction reveals 264 common targets MS‐related genes. Protein‐protein interaction analysis establishes complex network, identifying like SRC AKT1. Bioinformatics enrichment uncovers candidates pathways. A Biomolecule‐Target‐Pathway diagram visualizes interactions, Liriodenine exhibiting strong binding affinities in studies. Molecular dynamics simulations provide insights into In conclusion, through advanced techniques, it unveils therapies, pathways, bridging predictions practical applications. show promise curbing MS biomarkers.
Язык: Английский
Процитировано
0
Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 289, С. 117686 - 117686
Опубликована: Янв. 1, 2025
Luffa cylindrica (L.), is a medicinal plant aimed to investigate the efficacy of alkaloid-rich fraction (ARF) extracted from L. cylindrica. The study employed behavioural analysis rat using Morris water maze (MWM), biochemical apoptotic proteins, Immunohistochemistry caspase 3 protein and network pharmacology approach. ozone-induced group exhibited complex behavioral changes. Western blot revealed altered expression SOD2, Caspase 3, Cytochrome C which play integral roles in oxidative stress, apoptosis, mitochondrial function. Histopathological hippocampus further supported neuroprotective potential cylindrica, demonstrating reduction neuropathological lesions improved memory processes. Network Pharmacology showed implication GSK3β neuronal damage. ARF promise preventing In summary, this comprehensive sheds light on its applications by vivo molecular analyses. It provides holistic understanding properties ARF, encouraging exploration for therapeutic interventions neurological diseases.
Язык: Английский
Процитировано
0
Zeitschrift für Naturforschung C, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Abstract A major problem in chronic kidney illnesses is renal fibrosis. This research investigates the therapeutic potential of compounds derived from Nelumbo nucifera (Lotus). Comprehensive screening identified these compounds, which exhibit promising binding affinities with key targets associated Leriodenine and Nuciferine demonstrate substantial by modulating critical such as PTGS2, JUN, EGFR, STAT3, mTOR, AKT1. The biomolecule-target-pathway network highlights intricate interactions underlying effects lotus seed Strong PTGS2-PDBID:5F19, −8.99 kcal/mol −9.33 kcal/mol, JUN-PDBID:1S9K, −7.95 −7.05 are shown molecular docking investigations, indicating their fibrotic process inhibitors. During 10 ns simulations, demonstrated robust hydrogen-bonding connections within protein’s active site, leading to a possible alteration conformation ligand-binding site. establishes foundation for future experimental validation, clinical trials, bridge translational gap. combines target prediction, protein–protein interaction studies, biomolecular clarify pathways behind We also carried out Insilico dynamics simulation best compound obtain more precise results.
Язык: Английский
Процитировано
0
Inflammopharmacology, Год журнала: 2025, Номер unknown
Опубликована: Март 12, 2025
Abstract Alzheimer’s disease (AD) is a widespread condition that affects adults and the community considerably. The causes are yet unknown, except from advanced age genetic predisposition. Natural products provided advantageous advantages for managing AD due to their efficacy, safety, accessibility. memory boosting effects of chemically characterized Ipomoea carnea ethanol extract (IPC-EtOH) on behavioral, biochemical, histological, molecular levels against cognitive impairment induced by AlCl 3 exposure in rats were assessed using donepezil as reference drug. Behavioral tests (spontaneous alternation T-maze open field test) assays GSK3β, CREB, FOXO1a, β-secretase, tau, oxidative stress biomarkers, histopathology, immunohistochemistry cyclooxygenase 2 (COX-2) conducted. chemical profiling IPC-EtOH UPLC-ESI–qTOF-MS coupled with networking revealed identification 83 bioactive metabolites, including pyrrolizidine alkaloids cinnamic acid derivatives which previously undescribed this species. injection significantly elevated β -secretase, GSSG, GSK-3 , FOXO3a down regulated CAT, SOD, strong COX-2 immunoexpression cortex hippocampus compared controls. Oral co-administration or -treated restored near-normal function these brain regions, attenuating spatial learning, memory, locomotor impairments. These results suggest could be promising therapy mitigating aluminum-induced neurotoxicity, though further studies needed elucidate its precise mechanisms action. outcomes emphasize I. extract’s potential an appealing demonstrating neuroprotective memory-enhancing properties having -induced impairment.
Язык: Английский
Процитировано
0
Future Science OA, Год журнала: 2023, Номер 10(1)
Опубликована: Окт. 4, 2023
Aim: Alzheimer's disease causes dementia which impairs the cognitive domains. Methodology: The pharmacokinetic characteristics and biological activity of echinocystic acid are predicted in this work using silico or computational approaches, including pkCSM, Swiss ADME, OSIRIS® property explorer, PASS online web resource MOLINSPIRATION® software. Results & discussion: compound has lipid metabolism regulating as major role decreasing progression it no side effects ADR. drug also anti-inflammatory properties can help innate immunity that plays a disease. Conclusion: From screening, we infer that, regulate memory loss, disability slow down disease-like pathology.
Язык: Английский
Процитировано
6
Future Science OA, Год журнала: 2024, Номер 10(1)
Опубликована: Апрель 17, 2024
Aim: The aim of this research is to investigate the potential glucomoringin, derived from Moringa oleifera, as a therapeutic agent for Alzheimer's disease through in silico analysis. Materials & methods: This study employs or computational methodologies, including pkCSM, Swiss ADME, OSIRIS® property explorer, PASS online web resource and MOLINSPIRATION® software, predict pharmacokinetic characteristics biological activity glucomoringin. Results conclusion: Molecular docking indicates strong binding I-1β profile shows cytochrome P450 enzyme inhibition, prompting further dosing strategies. Toxicological predictions affirm safety, while bioactivity assessments demonstrate versatility modulating essential pathways. glucomoringin's treatment, emphasizing need additional empirical research.
Язык: Английский
Процитировано
1
Archives of Microbiology, Год журнала: 2024, Номер 206(11)
Опубликована: Окт. 29, 2024
Язык: Английский
Процитировано
1
Future Science OA, Год журнала: 2024, Номер 10(1)
Опубликована: Ноя. 19, 2024
Introduction Chronic migraine is recognized by the WHO as one of most debilitating chronic conditions. It primarily caused central sensitization trigeminal nucleus caudalis. Key biomarkers associated with include NFkB, IL-1β, CGRP, and iNOS. While CGRP antagonists have proven effective in treating migraines, Chrysanthemum indicum L., a traditional herbal remedy, has not been established treatment.
Язык: Английский
Процитировано
1
Future Science OA, Год журнала: 2024, Номер 10(1)
Опубликована: Апрель 16, 2024
Aim: This study endeavors to explore the anti-arthritic effects of macerated oil derived from plant's aerial parts. Methods: The was prepared using maceration in coconut oil, and its phytochemical composition elucidated GC-MS. To assess activity, in-vitro studies were conducted various assays. Results & conclusion: showed better antioxidant potential by investigations. Molecular docking binding interactions between specific constituents critical molecular targets implicated pathogenesis arthritis, further substantiating therapeutic potential. results demonstrated that Abrus precatorius could ameliorate arthritis severity a dose-dependent manner.
Язык: Английский
Процитировано
0
International Journal of Research and Review, Год журнала: 2024, Номер 11(7), С. 369 - 377
Опубликована: Июль 26, 2024
Luffa cylindrica, commonly referred to as sponge gourd or Loofa, is a versatile plant species with rich pharmacological profile and diverse chemical constituents. This review delves into its extensive therapeutic potential, encompassing wide range of actions such antioxidant, anti-inflammatory, anti-cancer, antimicrobial, antiviral, antipyretic, hepatoprotective, wound healing, uterotonic, anti-emetic, sedative, anti-epileptic properties. Its bioactive compounds, including triterpenoid saponins, flavonoids, peptides, are distributed across different parts the plant, fruits, leaves, seeds. Originating in sub-tropical regions, L. cylindrica primarily cultivated countries China, India, Central America. significant traditional uses folk medicine for treating various ailments further underscore medicinal importance potential modern applications. The plant's richness, coupled distribution uses, positions promising candidate exploration drug discovery healthcare product development. With ongoing research compounds mechanisms action, there identification novel agents. Additionally, advancements cultivation techniques processing methods may facilitate development innovative pharmaceutical formulations natural remedies. Overall, represents valuable botanical resource vast implications both medicine. Keywords: Pharmacological Phytochemical constituents, Distribution.
Язык: Английский
Процитировано
0