Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases DOI Creative Commons

Rachid Kacemi,

María G. Campos

Antioxidants, Год журнала: 2025, Номер 14(3), С. 265 - 265

Опубликована: Фев. 25, 2025

Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.

Язык: Английский

Mitigating Diabetic Cardiomyopathy: The Synergistic Potential of Sea Buckthorn and Metformin Explored via Bioinformatics and Chemoinformatics DOI Creative Commons
Kamran Safavi, Navid Abedpoor, Fatemeh Hajibabaie

и другие.

Biology, Год журнала: 2025, Номер 14(4), С. 361 - 361

Опубликована: Март 31, 2025

Diabetic cardiomyopathy (DCM), a critical complication of type 2 diabetes mellitus (T2DM), is marked by metabolic dysfunction, oxidative stress, and chronic inflammation, ultimately progressing to heart failure. This study investigated the synergistic therapeutic potential Hippophae rhamnoides L. (sea buckthorn, SBU) extract metformin in mouse model T2DM-induced DCM. T2DM was induced using 45% high-fat-AGEs-enriched diet, followed treatment with SBU, metformin, or their combination. Treatment effects were monitored through bioinformatic analysis, chemoinformatic prediction, behavioral testing, biochemical assays, histopathological evaluations gene expression profiles. Based on we identified key hub genes involved diabetic including SERPINE1, NRG1, MYH11, PTH, NR4A2, NRF2, PGC1α, GPX4, ATF1, ASCL2, NOX1, NLRP3, CCK8, COX2, CCL2, PTGS2, EGFR, oncostatin, which are pivotal modulating ferroptosis pathway. Furthermore, long non-coding RNAs (lncRNAs) NEAT1 MALAT1, regulators inflammation cell death, effectively downregulated, correlating decreased levels pro-inflammatory marker oncostatin. The combined therapy significantly improved glucose regulation, reduced systemic protected from damage. Histopathological analysis revealed notable reductions cardiac necrosis fibrosis. Particularly, combination SBU demonstrated effect, surpassing benefits individual treatments preventing These findings highlight integrating as novel strategy for managing DCM targeting both ferroptosis-related pathways. dual intervention opens promising avenues future clinical applications disease management, offering comprehensive approach mitigating progression

Язык: Английский

Процитировано

0
Diamagnetic Signature of Beta‐Amyloid (Aβ) and Tau (τ) Tangle Pathology in Alzheimer's Disease: A Review DOI Creative Commons
Sadegh Ghaderi, Sana Mohammadi, Farzad Fatehi

и другие.

Aging Medicine, Год журнала: 2025, Номер 8(1)

Опубликована: Фев. 1, 2025

ABSTRACT The complex interplay between diamagnetic and paramagnetic substances within the brain, particularly in context of Alzheimer's disease (AD), offers a rich landscape for investigation using advanced quantitative neuroimaging techniques. Although conventional approaches have focused on properties iron, emerging promising research has highlighted significance signatures associated with beta‐amyloid (Aβ) plaques Tau (τ) protein aggregates. Quantitative susceptibility mapping (QSM) is post‐processing technique that visualizes characterizes these subtle alterations brain border tissue composition, such as gray–white matter interface. Through voxel‐wise separation contributions sources, QSM enabled identification quantification Aβ τ aggregates, even presence iron. However, several challenges remain utilizing clinical applications. These include relatively small magnitude signal compared to need high‐resolution imaging sophisticated analysis techniques, standardization acquisition protocols. Further necessary refine optimize parameters, develop robust pipelines improve sensitivity specificity detecting nature As our understanding continues evolve, expected play pivotal role advancing knowledge AD other neurodegenerative diseases.

Язык: Английский

Процитировано

0
Targeting ferroptosis in the treatment of ulcerative colitis by traditional Chinese medicine: A novel therapeutic strategies DOI
Ying Liu,

Jing-Tian Zhang,

Meng Sun

и другие.

Phytomedicine, Год журнала: 2025, Номер 139, С. 156539 - 156539

Опубликована: Фев. 17, 2025

Язык: Английский

Процитировано

0
Application prospects of ferroptosis in colorectal cancer DOI Creative Commons

Gen Yang,

Biyun Qian, Liya He

и другие.

Cancer Cell International, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 21, 2025

Colorectal cancer (CRC) is a serious threat to human health with the third morbidity and second cancer-related mortality worldwide. It urgent explore more effective strategy for CRC because of acquired treatment resistance from non-surgical conventional therapies, including radiation, chemotherapy, targeted therapy immunotherapy. Ferroptosis novel form programmed cell death characterized by iron-dependent lipid peroxidation species (ROS) accumulation has been identified as promising target treatment, especially those resistance. In this review, we mainly summarize recent studies on influence regulation ferroptosis which (including gut microbiota) modulating metabolism iron, amino acid lipid. Thus analysis may provide potential targets inducing shed lights future application in CRC.

Язык: Английский

Процитировано

0
Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases DOI Creative Commons

Rachid Kacemi,

María G. Campos

Antioxidants, Год журнала: 2025, Номер 14(3), С. 265 - 265

Опубликована: Фев. 25, 2025

Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.

Язык: Английский

Процитировано

0