Annual Research Review: Micronutrients and their role in the treatment of paediatric mental illness DOI Open Access
Julia J. Rucklidge, Alisha M. Bruton,

Alanna Welsh

и другие.

Journal of Child Psychology and Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

The aim of this narrative review is to summarize evidence relating the importance nutrient intake from diet and supplementation for paediatric mental health. We begin by reviewing several mechanisms which nutrients maximize brain health, including enabling metabolic reactions occur, supporting mitochondrial function, reducing inflammation assisting with detoxification. Circumstances that may contribute an individual requiring additional beyond what are available in diet, such as consumption nutritionally depleted food, differences biological need, long-term medication use gut-brain health needs then reviewed. These factors underpin tackling deficiencies relative requirements a broad spectrum micronutrients, opposed single approach, address personal and/or environmentally induced depletions. treating psychological symptoms supplementary micronutrients presented, summarizing research using broad-spectrum treatment issues aggression, autism disorder, attention-deficit/hyperactivity disorder emotional dysregulation, often medium between-group effect sizes compared placebo, clinically meaningful changes. breadth consistency findings highlight receiving complete foundation optimize health; however, small number studies identifies future work replicate these preliminary findings. Documented safety 8-week randomized controlled trials open-label extensions up 16 weeks longer-term follow-up 1.5-5 years smaller samples provide reassurance approach does not result serious adverse events. recommendations micronutrient interventions, scalable delivery models, effectiveness implementation need investigate interventions prevention management less-studied childhood psychiatric conditions.

Язык: Английский

Randomised Control Trial Indicates Micronutrient Supplementation May Support a More Robust Maternal Microbiome for Women with Antenatal Depression During Pregnancy DOI Creative Commons
Aaron J. Stevens,

Thalia M Heiwari,

Fenella J. Rich

и другие.

Clinical Nutrition, Год журнала: 2024, Номер 43(11), С. 120 - 132

Опубликована: Сен. 18, 2024

Язык: Английский

Процитировано

2
Broad-Spectrum Micronutrients or Antidepressants for Antenatal Depression DOI Creative Commons

Jessica L. Heaton,

Siobhan A. Campbell,

Hayley A. Bradley

и другие.

Journal of Clinical Psychopharmacology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 2, 2024

Purpose/Background One-fifth of women experience antenatal depression. Untreated depression is associated with increased risk adverse birth outcomes. This study investigated the effect broad-spectrum micronutrients (BSM; vitamins and minerals), used to treat (NUTRIMUM trial), on Methods/Procedures Birth outcomes 129 mother-infant pairs were obtained from hospital medical records or personal health for home births. Pairs NUTRIMUM exposed ≥8 weeks BSM antenatally (MN; n = 55) compared antidepressants (MED; 20) a reference group (REF; 54) not trial antidepressants. Findings/Results Groups comparable demographic variables. At entry, MN MED had scores in moderate range, statistically higher than REF (nonclinical range). did differ significantly gestational age, preterm births, infant size, resuscitation. There lower rates postpartum hemorrhage relative (7.7% vs 30%; RR 0.26, 95% CI [0.08–0.84]). Gestational age at was (39.5 weeks) (38.5 weeks; d 0.67, [0.15–1.20], P 0.03) as well length (52.2 50.0 cm; 0.77, [0.21–1.33], 0.02), resuscitation (14.5% 45%; 0.33, [0.15–0.73]). Days exposure positively weight ( r 0.32, 0.008) 0.25, 0.04). Implications/Conclusions Micronutrients alleviate may mitigate negative effects showed more favorable

Язык: Английский

Процитировано

2
Annual Research Review: Micronutrients and their role in the treatment of paediatric mental illness DOI Open Access
Julia J. Rucklidge, Alisha M. Bruton,

Alanna Welsh

и другие.

Journal of Child Psychology and Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

The aim of this narrative review is to summarize evidence relating the importance nutrient intake from diet and supplementation for paediatric mental health. We begin by reviewing several mechanisms which nutrients maximize brain health, including enabling metabolic reactions occur, supporting mitochondrial function, reducing inflammation assisting with detoxification. Circumstances that may contribute an individual requiring additional beyond what are available in diet, such as consumption nutritionally depleted food, differences biological need, long-term medication use gut-brain health needs then reviewed. These factors underpin tackling deficiencies relative requirements a broad spectrum micronutrients, opposed single approach, address personal and/or environmentally induced depletions. treating psychological symptoms supplementary micronutrients presented, summarizing research using broad-spectrum treatment issues aggression, autism disorder, attention-deficit/hyperactivity disorder emotional dysregulation, often medium between-group effect sizes compared placebo, clinically meaningful changes. breadth consistency findings highlight receiving complete foundation optimize health; however, small number studies identifies future work replicate these preliminary findings. Documented safety 8-week randomized controlled trials open-label extensions up 16 weeks longer-term follow-up 1.5-5 years smaller samples provide reassurance approach does not result serious adverse events. recommendations micronutrient interventions, scalable delivery models, effectiveness implementation need investigate interventions prevention management less-studied childhood psychiatric conditions.

Язык: Английский

Процитировано

1