Feasibility and psychometric quality of smartphone administered cognitive ecological momentary assessments in women with metastatic breast cancer

Digital Health, Год журнала: 2025, Номер 11

Опубликована: Янв. 1, 2025

Objective Metastatic breast cancer (MBC) is associated with burdensome side effects, including cognitive changes that require ongoing monitoring. Cognitive ecological momentary assessments (EMAs) allow for assessment of individual functioning in natural environments and can be administered via smartphones. Accordingly, we sought to establish the feasibility, reliability, validity a commercially available EMA platform. Methods Using prospective design, clinical psychosocial (cognitive batteries; patient reported outcomes) were collected at baseline, followed by 28-day daily protocol included self-ratings symptoms mobile tests (memory, executive functioning, working memory, processing speed). Satisfaction feedback questions follow-up data collection. Feasibility analyzed using mixed descriptive methods. Test-retest reliability was examined intraclass correlation coefficients (ICCs) each EMA, Pearson's used evaluate convergent between EMAs baseline variables. Results Fifty-one women MBC ( n = 51) completed this study. High satisfaction (median 90%), low burden 19%), high adherence rates (mean 94%), 100% retention rate observed. ICCs function, speed robust (>0.90) ICC memory acceptable (>0.66). Other correlational findings indicated strong all EMAs. Conclusion monitoring 28 days feasible MBC, specific (mobile tests; function self-ratings) demonstrating validity.

Язык: Английский

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Physical Activity Patterns and Relationships With Cognitive Function in Patients With Breast Cancer Before, During, and After Chemotherapy in a Prospective, Nationwide Study

Journal of Clinical Oncology, Год журнала: 2021, Номер 39(29), С. 3283 - 3292

Опубликована: Авг. 18, 2021

Physical activity (PA) is a promising intervention for cancer-related cognitive decline, yet research assessing its use during chemotherapy limited. This study evaluated patterns of PA before, during, and after in patients with breast cancer the association between function.

Язык: Английский

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Cognitive performance of breast cancer survivors in daily life: Role of fatigue and depressed mood

Psycho-Oncology, Год журнала: 2019, Номер 28(11), С. 2174 - 2180

Опубликована: Авг. 16, 2019

Cancer and its treatment are associated with long-term cognitive deficits. However, most studies of cancer patients have used traditional, office-based evaluations instead assessing in their daily lives. Recent research aging suggests that variability performance may be a sensitive indicator decline. Using ecological momentary assessment (EMA), we examined among breast survivors evaluated whether ratings fatigue depressed mood were cognition.Participants 47 women (M age = 53.3 years) who completed for early stage 6 to 36 months previously. Smartphones preloaded tests measuring processing speed, executive functioning, memory, as well rating scales mood. Participants prompted five times per day over 14-day period complete EMA tasks ratings.Cognitive was observed across all three tasks. Processing speed responses slower at rated themselves more fatigued than average (P < .001). Ratings not cognition.This study is the first report lives treated cancer. Performance worse on measure when woman her greater own average. The ability identify moments cognition vulnerable allow personalized interventions applied they needed.

Язык: Английский

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Characterizing cancer-related cognitive impairments and impact on quality of life in women with metastatic breast cancer

Breast Cancer Research and Treatment, Год журнала: 2024, Номер unknown

Опубликована: Сен. 13, 2024

Язык: Английский

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Perceived cognitive impairment and occupational functioning in prostate cancer survivors: an exploratory cross-sectional analysis

Journal of Cancer Survivorship, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Abstract Purpose Perceived cancer-related cognitive impairment (CRCI) has been reported in prostate cancer survivors. Little is known about how CRCI impacts occupational functioning working-aged survivors (PCS). This study aimed to investigate the association between and PCS. Methods Data from 51 PCS, who were employed at time of diagnosis, undergoing hormonal treatments (e.g., androgen deprivation therapy) or ‘watchful waiting’/ ‘active surveillance’, analysed. An online survey assessed using FACT-Cog Cognitive Impairments (PCI20) subscale, EORTC-QLQ-30 two-item scale, a single ‘Yes/No’ item (i.e., ‘changes thinking memory, attention)’ experienced as treatment side effect). PCS also indicated changes their ability work, performance work duties, decreased hours. Logistic regression analyses examined relationship measures outcomes. Results Of 19 (37%) endorsed experiencing effects treatment. The question was significantly associated with perceived perform duties same level. PCI20 scale not any Conclusion adverse important consider when are making plans return-to-work following Implications for Cancer Survivors Prostate may experience changes, which impact ability.

Язык: Английский

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Long-Term Cognitive Outcomes in Adult Patients Receiving Chimeric Antigen Receptor T-Cell Therapies

Transplantation and Cellular Therapy, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Immune checkpoint inhibitors and cancer-related cognitive decline: a propensity score matched analysis in active chemotherapy patients

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 7, 2025

Background We investigated whether 1-year trajectories of cancer-related cognitive decline (CRCD) would be different in patients with chemotherapy combined immune checkpoint inhibitors (chemoICI group) as compared alone (chemo group). Methods Participants scheduled or without ICI were prospectively recruited from three academic hospitals and followed up for 1 year four sessions. Subjective objective CRCD measured by Perceived Cognitive Impairment (PCI) Montreal Assessment (MoCA), respectively. Primary endpoints MoCA PCI score changes minimal clinically important difference (MCID), which was defined threshold meaningful impairment events. Propensity matching (PSM) performed group comparison using logistic regression covariates including age, cancer stage, baseline scores. Linear mixed models adjusted repeated measures. Results Out 1557 PSM yielded 460 patient pairs (1:1). Mean scores both groups reached MCID at 12-month session groups. In chemoICI, significantly lower the session, 6, 9, sessions than chemo (P&lt;0.05). One-year events risks 0.44 0.56 higher that (0.35 0.38, P&lt;0.01). Significant differences found mean event-free survival time irAE chemoICI subgroup analysis. Conclusions Our findings suggest combining ICIs may exacerbate to alone. However, reliance on screening tools self-reported measures limits definitive conclusions. Future studies incorporating comprehensive neuropsychological assessments are warranted. This study underscores importance future research better understand impact function.

Язык: Английский

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Screening for cognitive symptoms among cancer patients during chemotherapy: Sensitivity and specificity of a single item self‐report cognitive change score

Psycho-Oncology, Год журнала: 2022, Номер 31(8), С. 1294 - 1301

Опубликована: Март 23, 2022

Cognitive symptoms are commonly reported among cancer patients and survivors, yet guidance on when self-reported cognitive warrant follow-up is lacking. We sought to establish cut-off scores for identifying with perceived low functioning widely used self-report measures of cognition a novel single item Change Score.Adult diagnosed invasive who had completed at least one cycle chemotherapy questionnaire containing the EORTC-Cognitive Function (CF) subscale, Functional Assessment Cancer Therapy-Cognitive (FACT-COG) Perceived Impairment (PCI) our Score (CCS). receiver operating characteristic analyses discriminative ability these against Patient's Own Functioning Inventory (PAOFI) as reference standard. chose each measure that maximised both sensitivity specificity CF.We recruited 294 participants (55.8% women, mean age 56.6 years) mixed diagnoses (25.5 months since diagnosis). On CCS, 77.6% some change starting chemotherapy. PAOFI 36% CF. The following identified cases CF: ≥28.5 CCS (75.5% sensitivity, 67.6% specificity); ≤75.0 European Organisation Research Treatment Cancer, QLQ-C30 scale (90.9% 57.1% ≤55.1 FACT-COG PCI-18 (84.8% 76.2% specificity), ≤59.5 PCI-20 (78.8% 84.1% specificity).We found question asking about has acceptable discrimination between normal CF compared other more comprehensive symptoms. Further validation work required.

Язык: Английский

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Structural equation modelling of the role of cognition in functional interference and treatment nonadherence among haemodialysis patients

PLoS ONE, Год журнала: 2024, Номер 19(10), С. e0312039 - e0312039

Опубликована: Окт. 17, 2024

Cognitive impairment is common in haemodialysis patients and associated with adverse health outcomes. This may be due to cognitive impairments interfering daily functioning self-care, but evidence limited. cross-sectional study aims explore the interrelationships between cognition functional outcomes patients.

Язык: Английский

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Subjective cognition and memory lapses in the daily lives of breast cancer survivors: Examining associations with objective cognitive performance, fatigue, and depressed mood

Psycho-Oncology, Год журнала: 2023, Номер 32(8), С. 1298 - 1305

Опубликована: Июнь 28, 2023

Abstract Objective Subjective reports of cancer‐related cognitive impairment often far exceed that documented using in‐person neuropsychological assessment. This study evaluated whether subjective cognition was associated with real‐time objective performance in daily life versus on an battery, as well fatigue and depressed mood. Methods Participants were 47 women (M age = 53.3 years) who completed adjuvant treatment for early‐stage breast cancer 6–36 months previously. During assessment, participants a battery questionnaires cognition, fatigue, Over 14 days, responded to up 5 prompts assessed processing speed memory self‐reported ratings mood fatigue. In the evenings, rated their day reported lapses (e.g., forgetting word). Results worse mood, but did not exhibit poorer performance. Women more demonstrate cognition. Finally, at end demonstrated better ( p 0.001), visuospatial skills 's ≤ 0.02). Conclusion consistently Specific related suggests incorporating may help clinicians identify those objectively measured impairment.

Язык: Английский

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