Cognitive impairment in cervical cancer survivors—Exploring the discrepancy between subjective and objective assessment

Psycho-Oncology, Год журнала: 2024, Номер 33(2)

Опубликована: Фев. 1, 2024

Abstract Objective Cancer‐related cognitive impairment has severe implications for the quality of life and societal participation cervical cancer survivors (CCS). However, there is no research on association between subjective objective (CI) in cancer. This cross‐sectional study aimed to examine frequency severity CI CCS reporting significant explore discrepancy CI. Methods Sixty‐five CI, defined as 1.5 SD below normative mean, underwent neuropsychological (NP) assessment covering attention, verbal memory, processing speed, fluency, executive functions. were compared healthy age‐matched controls ( n = 74). A versus score was calculated based standardized scores within each group. Results The group performed significantly poorer across all NP tests (all p ‐values <0.001) 81.5% had cut‐off by International Cognition Cancer Task Force. published data, most clinically normal range. Processing speed memory affected domains. By calculating a score, both groups average displayed quite accurate concordance functioning. Conclusion Although evident CCS, our results confirm that represent different constructs highlight limitations data. Differentiating important when tailoring effective interventions survivorship care CCS.

Язык: Английский

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Factors associated with cognitive impairment and cognitive concerns in patients with metastatic non-small cell lung cancer

Neuro-Oncology Practice, Год журнала: 2021, Номер 9(1), С. 50 - 58

Опубликована: Сен. 7, 2021

Abstract Background Knowledge regarding cognitive problems in metastatic non-small cell lung cancer (mNSCLC) is limited. Such may include both patient-reported concerns and demonstrable impairment. Greater understanding of these outcomes needed to inform rehabilitation strategies for difficulties. We aimed identify the frequency associated factors patients with mNSCLC. Methods In this cross-sectional study, adults mNSCLC completed validated neuropsychological tests self-report questionnaires measuring concerns, neurobehavioral depression, demoralization, illness intrusiveness, self-esteem, physical symptoms. Cognitive impairment (performance based) was defined according International Cancer Cognition Task Force criteria. Clinically significant were by a score ≥1.5 SD below normative mean on Functional Assessment Therapy-Cognitive Function Perceived Impairment (FACT-Cog PCI). Univariate multivariate logistic regression analyses performed factors. Results Of 238 approached, 77 participated (median age: 62 years; range: 37-82). Brain metastases present 41 (53%), 23 (29%) received cranial irradiation. 31 (40%) 20 (26%), respectively. co-occurred 10 (13%), but their severity unrelated. irradiation (odds ratio [OR] = 2.89; P .04), whereas greater intrusiveness (OR 1.04; .03) lower self-esteem 0.86; .03). Conclusions are common not necessarily related, risk differ. The association can therapeutic interventions population.

Язык: Английский

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Domain‐specific relationships of subjective and objective cognition in epilepsy

Epilepsia, Год журнала: 2023, Номер 64(7), С. 1887 - 1899

Опубликована: Апрель 21, 2023

Many people with epilepsy report subjective cognitive impairment (SCI), i.e., problems memory, attention, or executive functions, reducing quality of life. Nevertheless, overlap objective (OCI) is often weak. One reason may be a domain-specific mismatch between reports and tests. We aimed to evaluate relations SCI OCI corresponding domains assess whether these differ persons who over- underestimate their performance.In this prospective, cross-sectional sample 104 adult inpatients epilepsy, we performed multiple regression analyses predicting in the functions. tested relationships measures psychomotor speed, short-term verbal learning, delayed recall, word fluency while controlling for age, sex, seizure frequency, structural lesions, mono- versus polytherapy adverse events antiseizure medication (ASM), depressive anxiety symptoms, level education, employment status. Furthermore, differed realistic raters underestimators.We found attention functions full sample, explaining small proportion variance (general dominance index = .03 .004), whereas ASM psychological variables were more important predictors. When dividing according concordance OCI, high frequencies both (23%-46%) underestimation (31%-35%) depending on domain. The explanatory power was stronger within subgroups compared suggesting nonlinear different underlying mechanisms raters, underestimators, overestimators.Domain-specific are related, should assessed standardized instruments. These underestimators as well raters. Based self-ratings measures, tailored counseling treatment offered.

Язык: Английский

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Clinical and Genetic Risk Prediction of Cognitive Impairment After Blood or Marrow Transplantation for Hematologic Malignancy

Journal of Clinical Oncology, Год журнала: 2020, Номер 38(12), С. 1312 - 1321

Опубликована: Фев. 21, 2020

Using a candidate gene approach, we tested the hypothesis that individual single nucleotide polymorphisms (SNPs) and gene-level variants are associated with cognitive impairment in patients hematologic malignancies treated blood or marrow transplantation (BMT) inclusion of these SNPs improves risk prediction beyond offered by clinical demographic characteristics.In discovery cohort, BMT recipients underwent standardized battery neuropsychological tests pre-BMT at 6 months, 1 year, 2 years, 3 years post-BMT. Associations between 68 genes were assessed using generalized estimating equation models. Elastic-Net regression was used to build Base (sociodemographic), Clinical, Combined (Base plus Clinical genetic) models post-BMT impairment. An independent nonoverlapping cohort from Survivor Study self-report learning/memory problems (as identified their health care provider) for model replication.The included 277 participants (58.5% males; 68.6% non-Hispanic whites; 46.6% allogeneic recipients). Adjusting type, age BMT, sex, race/ethnicity, reserve, blood-brain barrier, telomere homeostasis, DNA repair significantly Compared Model, Model had higher predictive power both (mean area under receiver operating characteristic curve [AUC], 0.89; 95% CI, 0.85 0.93 v 0.77; 0.71 0.83; P = 1.24 × 10-9) replication (AUC, 0.71; 0.66 0.76 0.63; 0.57 0.68; .004).Inclusion genetic enhanced demographic/clinical characteristics represents step toward personalized approach managing high after BMT.

Язык: Английский

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Cancer‐related cognitive impairment in survivors of adolescent and young adult non‐central nervous system cancer: A scoping review

Psycho-Oncology, Год журнала: 2022, Номер 31(8), С. 1275 - 1285

Опубликована: Июнь 21, 2022

Cancer-related cognitive impairments (CRCI) are common after treatment and can have important impacts on the lives of adolescent young adult (AYA) cancer survivors-those survivors diagnosed between ages 15 39. However, most research focuses under age or over 39 so we know relatively little about CRCI among AYA non-central nervous system (CNS) cancers. Here review non-CNS cancers to determine prevalence, associated factors, impact survivors' as well implications for future research.In November 2021 performed a systematic search literature in MEDLINE, Web Science, PsycInfo, CINAHL, EMBASE, Cochrane Central Register Controlled Trials identify peer-reviewed English language articles describing original with at least one outcome conducted AYAs. We screened 6003 21 met eligibility criteria. Guided by PRISMA-ScR Checklist, extracted study information meet objectives.Most studies employed cross-sectional surveys interviews, though some longitudinal methods, neurocognitive assessments, brain imaging. From subset that reported prevalence calculated weighted mean 25.75% median 27.8%. The factors included female gender, higher dose chemotherapy, comorbidities. impacted through impaired role functioning, financial toxicity, unmet needs.CRCI is highly prevalent AYAs quality life functioning. This suggests need further longitudinal, imaging, mixed methods provision resources help achieve better educational occupational attainment during what potentially decades-long survivorship period. although interventions might improve cognition identified only pilot study. Digital may be practical effective option this group, but they yet adequately investigated.

Язык: Английский

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Assessing cancer-related cognitive function in the context of everyday life using ecological mobile cognitive testing: A protocol for a prospective quantitative study

Digital Health, Год журнала: 2023, Номер 9

Опубликована: Янв. 1, 2023

Objective Millions of cancer survivors are at risk for cancer-related cognitive impairment (CRCI), yet accurate and accessible assessments functioning remain limited. Ecological mobile testing (EMCT) could offer a solution. This paper presents the protocol study that aims to (1) establish reliability validity EMCT assess CRCI in breast survivors, (2) prospectively evaluate within-person processes (and interactions) among context, mood, behavior explain variability, everyday functioning, quality life survivors. Methods Participants will include (>21 years old) who within 5 completing chemotherapy treatment. complete two virtual visits (baseline, follow-up) 2 months apart self-reported symptoms performance, sociodemographic characteristics, clinical history, life. Between visits, be used sample every other day (28 times total). We use linear mixed-effect regressions single-level multiple regression models analyze data. Results anticipate minimum 124 enrolling data collection. Study results published peer-reviewed scientific journals. Conclusions Our findings have broad implications assessing an ecologically valid person-centered way using EMCT. aim provide this aid researchers would like apply approach their studies.

Язык: Английский

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Neuroimaging based biotypes for precision diagnosis and prognosis in cancer-related cognitive impairment

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Авг. 29, 2023

Cancer related cognitive impairment (CRCI) is commonly associated with cancer and its treatments, yet the present binary diagnostic approach fails to capture full spectrum of this syndrome. Cognitive function highly complex exists on a continuum that poorly characterized by dichotomous categories. Advanced statistical methodologies applied symptom assessments have demonstrated there are multiple subclasses CRCI. However, studies suggest relying alone may fail account for significant differences in neural mechanisms underlie specific phenotype. Treatment plans address physiologic involved an individual patient’s condition heart precision medicine. In narrative review, we discuss how biotyping, medicine framework being utilized other mental disorders, could be Specifically, neuroimaging can used determine biotypes CRCI, which allow increased prediction diagnosis CRCI via biologic mechanistic data. Biotypes also provide more precise clinical endpoints intervention trials. Biotyping made feasible proxy imaging technologies or liquid biomarkers. Large cross-sectional phenotyping needed addition evaluation longitudinal trajectories, data sharing/pooling currently available digital infrastructures.

Язык: Английский

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Interactive effects of the BDNF Val66Met polymorphism and posttraumatic stress disorder on cognition in U.S. military veterans

Psychoneuroendocrinology, Год журнала: 2022, Номер 142, С. 105820 - 105820

Опубликована: Июнь 2, 2022

Язык: Английский

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Associating persistent self-reported cognitive decline with neurocognitive decline in older breast cancer survivors using machine learning: The Thinking and Living with Cancer study

Journal of Geriatric Oncology, Год журнала: 2022, Номер 13(8), С. 1132 - 1140

Опубликована: Авг. 24, 2022

Язык: Английский

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“I couldn't connect the wires in my brain.” Young adult cancer survivors' experience with cognitive functioning

Psycho-Oncology, Год журнала: 2024, Номер 33(3)

Опубликована: Фев. 29, 2024

Abstract Objective There is a dearth of literature describing young adult (YA) cancer survivors' experiences with cancer‐related cognitive impairment (CRCI). We aimed to elucidate CRCI among YA survivors and identify potentially modifiable risk factors. Methods conducted individual qualitative interviews aged 18–30 years at study enrollment used applied thematic analysis themes across three topics (i.e., affected abilities, protective factors influencing the impact CRCI, strategies for coping CRCI). Results ( N = 20) were, on average, 23 old diagnosis 26 when interviewed. Diverse types treatments were represented; most participants (85%) had completed treatment. Participants described topics: (1) abilities concentration attention, prospective memory, long‐term memory), (2) Risk fatigue, sleep problems, mood, stress/distractions, social isolation) support), (3) strategies, including practical that helped build self‐efficacy (e.g., writing things down, reducing distractions), beneficial emotion‐focused focus health, faith/religion), mixed effects apps/games, medications/supplements, yoga), “powering through” exacerbated stress. Conclusions experience enduring difficulties after Specific concerns highlight importance attention executive functioning impairments, memory recall, sensitivity distractions. Future work needed improve assessment treatment survivors.

Язык: Английский

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