Nano-spanlastics-loaded dissolving microneedle patches for ketotifen fumarate: advanced strategies for allergic conjunctivitis treatment and molecular insights

Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Язык: Английский

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Optimization of stereolithography 3D printing of microneedle micro-molds for ocular drug delivery

International Journal of Pharmaceutics, Год журнала: 2024, Номер 658, С. 124195 - 124195

Опубликована: Май 3, 2024

Microneedles (MN) have emerged as an innovative technology for drug delivery, offering a minimally invasive approach to administer therapeutic agents. Recent applications included ocular requiring the manufacture of sub-millimeter needle arrays in reproducible and reliable manner. The development 3D printing technologies has facilitated fabrication MN via mold production, although there is paucity information available regarding how parameters may influence crucial issues such sharpness penetration efficacy. In this study, we developed optimized 3D-printed micro-mold using stereolithography (SLA) prepare dissolving patch. effects range including aspect ratio, layer thickness, length, shape orientation been examined with regard both architecture accuracy micro-mold, while angle on fidelity was also basic shapes (conical, pyramidal triangular pyramidal). Mechanical strength vitro polymeric (PVP/PVA) patch produced from reverse molds fabricated height, ratios were assessed, followed by ex vivo studies into excised scleral corneal tissues. optimization process identified required produce sharpest tips highest dimensional fidelity, indicated that these systems would penetrate tissue minimal applied pressure, thereby allowing ease patient self-administration.

Язык: Английский

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Formulation Advances in Posterior Segment Ocular Drug Delivery

Journal of Ocular Pharmacology and Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Posterior segment ocular diseases, such as diabetic retinopathy, age-related macular degeneration, and retinal vein occlusion, are leading causes of vision impairment blindness worldwide. Effective management these conditions remains a formidable challenge due to the unique anatomical physiological barriers eye, including blood-retinal barrier rapid drug clearance mechanisms. To address hurdles, nanostructured delivery systems proposed overcome barriers, target retina, enhance permeation while ensuring controlled release. Traditional therapeutic approaches, intravitreal injections, pose significant drawbacks, patient discomfort, poor compliance, potential complications. Therefore, understanding physiology mechanism eye could aid in design novel formulations that be noninvasive deliver drugs reach site is pivotal for effective treatment strategies. This review focuses on recent advances formulation strategies posterior delivery, highlighting their limitations. Furthermore, nanocarrier in-situ gel, niosomes, hydrogels, dendrimers, liposomes, nanoparticles, nanoemulsions more effectively selectively explored, supplemented with illustrative examples, figures, tables. aims provide insights into current state emphasizing need interdisciplinary approaches develop patient-centric, minimally invasive, solutions.

Язык: Английский

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Dissolvable Microneedles assisted Minimally Invasive Transcleral Delivery of Conjugated Soluplus Nanomicelles targeting Retina in the management of Retinoblastoma

Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 103835 - 103835

Опубликована: Май 1, 2025

Язык: Английский

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Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery

Pharmaceutics, Год журнала: 2024, Номер 16(11), С. 1398 - 1398

Опубликована: Окт. 30, 2024

Microneedle technology revolutionizes ocular drug delivery by addressing challenges in treating diseases. This review explores its potential impact, recent advancements, and clinical uses. minimally invasive technique offers precise control of to the eye, with various microneedle types showing penetrate barriers cornea sclera, ensuring effective delivery. Recent advancements have improved safety efficacy, offering sustained controlled for conditions like age-related macular degeneration glaucoma. While promising, such as regulatory long-term biocompatibility persist. Overcoming these through interdisciplinary research is crucial. Ultimately, presents a revolutionary method significantly enhance disease treatment, marking new era eye care.

Язык: Английский

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Polymeric Microneedles for Biomedical Applications: Innovations in Transdermal Drug Delivery and Biosensing Technologies

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Язык: Английский

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Innovative Transdermal Delivery of Microneedle Patch for Dual Drugs Febuxostat and Lornoxicam: In Vitro and In Vivo Efficacy for Treating Gouty Arthritis

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 107053 - 107053

Опубликована: Май 1, 2025

Язык: Английский

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Designing biomaterials for the treatment of autoimmune diseases

Applied Materials Today, Год журнала: 2024, Номер 39, С. 102278 - 102278

Опубликована: Июнь 12, 2024

Язык: Английский

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Nanofiber-based Delivery of Luliconazole: Fabrication, Characterization, and Therapeutic Performance Assessment

AAPS PharmSciTech, Год журнала: 2024, Номер 25(5)

Опубликована: Май 6, 2024

Язык: Английский

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Denaturants and Solutol® HS15 in ophthalmic formulations: Insights into their combined effects

Journal of Molecular Liquids, Год журнала: 2024, Номер unknown, С. 126289 - 126289

Опубликована: Окт. 1, 2024

Язык: Английский

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