Quercetin loaded biogenic squalene nano-lipid carriers for the treatment of dry eye syndrome
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
674, С. 125457 - 125457
Опубликована: Март 10, 2025
Язык: Английский
Lipid Nanoparticles and Skin: Discoveries and Advances
Cosmetics,
Год журнала:
2025,
Номер
12(1), С. 22 - 22
Опубликована: Янв. 27, 2025
Nowadays,
skin
is
one
of
the
organs
most
commonly
affected
by
diseases
(infections,
inflammations,
and
injuries)
due
to
exposure
external
environment.
Although
topical
treatment
represents
suitable
administration
route,
it
poorly
effective
low
permeability
drug
through
skin.
Skin
delivery
lipid
nanocarriers
(LNs)
appears
be
a
therapeutic
strategy
overcome
these
issues,
allowing
reach
or
systemic
effect.
Several
LN-based
products
have
been
developed
enhance
permeation
bioactive
compounds
skin,
obtaining
interesting
results
in
both
pharmaceutical
cosmetic
fields.
Therefore,
this
review
aims
analyze
scientific
literature
regarding
use
LNs
treat
major
(psoriasis,
wound
healing,
atopic
dermatitis,
acne)
esthetic
defects
(wrinkles
cellulite).
Furthermore,
attention
has
paid
transdermal
application
(topical
formulations,
patches,
microneedles),
being
new
topic
recent
years.
Язык: Английский
Choline-based ionic liquids enhance the dermal delivery of cyclosporine a for potential treatment of psoriasis
Drug Delivery and Translational Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 5, 2024
Язык: Английский
Liposomal and Nanostructured Lipid Nanoformulations of a Pentacyclic Triterpenoid Birch Bark Extract: Structural Characterization and In Vitro Effects on Melanoma B16-F10 and Walker 256 Tumor Cells Apoptosis
Pharmaceuticals,
Год журнала:
2024,
Номер
17(12), С. 1630 - 1630
Опубликована: Дек. 4, 2024
Background/Objectives:
Pentacyclic
triterpenoids
are
increasingly
studied
as
anticancer
agents
with
many
advantages
compared
to
synthetic
chemotherapeutics.
The
aim
of
this
study
was
prepare
liposomal
and
nanostructured
lipid
formulations
including
a
standardized
extract
silver
birch
(Betula
pendula)
outer
bark
(TTs)
evaluate
their
potential
in
vitro,
using
Melanoma
B16-F10
Walker
carcinoma
cells.
Methods:
Appropriate
solvents
were
selected
for
efficient
TTs
extraction,
original
recipes
used
obtain
Pegylated
liposomes
nanolipid
complexes
entrapped
TTs,
comparative
pure
standards
(betulinic
acid
doxorubicin)
similar
conditions.
composition,
morphology,
sizes
all
nanoformulations
checked
by
high-performance
liquid
chromatography/mass
spectrometry,
Transmission
Electronic
Microscopy,
Diffraction
Light
Scattering.
entrapment
efficiency
its
impact
on
cell
viability,
cycle
arrest,
apoptosis
flow
cytometry
also
measured
both
cancer
lines.
Conclusions:
betulin,
lupeol,
betulinic
acid,
showed
good
stability
superior
activity
acid.
According
experimental
data,
NLC
nanoformulations,
delivery
systems
natural,
biodegradable
ingredients
enhanced
bioavailability.
necrosis
effects
more
pronounced
types
cells,
lower
cytotoxicity
Doxorubicin,
can
be
correlated
increased
Язык: Английский
Synthesis and Characterization of PEGylated Liposomes and Nanostructured Lipid Carriers with Entrapped Bioactive Triterpenoids: Comparative Fingerprints and Quantification by UHPLC-QTOF-ESI+-MS, ATR-FTIR Spectroscopy, and HPLC-DAD
Pharmaceuticals,
Год журнала:
2024,
Номер
18(1), С. 33 - 33
Опубликована: Дек. 31, 2024
Background/Objectives:
Pentacyclic
triterpenoids,
as
bioactive
phytochemicals,
have
proven
to
exhibit
significant
bioactivity
(antioxidant,
anti-inflammatory,
hypoglycemic,
and
anticancer)
low
cytotoxicity.
This
study
developed
convenient
methods
for
extracting
characterizing
a
birch
bark
extract
enriched
in
pentacyclic
triterpenoids
(betulin,
betulinic
acid,
lupeol)
entrapped
two
bioavailable
nanoformulations.
The
performance
of
ATR-FTIR
spectroscopy
cost-effective
non-destructive
method
was
evaluated
comparatively
with
accurate
HPLC-based
methods.
Methods:
pure
betulin
or
acid
were
used
obtain
PEGylated
liposomes
nano
lipid
carriers
(NLCs).
Their
size
characterized
by
light
scattering
diffraction.
UV-Vis
spectrometry
applied
preliminary
evaluation
(1),
well
UHPLC-QTOF-ESI+-MS
structure
identification
(2),
(for
semi-quantitative
evaluation)
(3),
HPLC-DAD
an
quantification
each
component,
either
the
organic
solvents
nanoformulations
(4).
Results:
had
smaller
sizes,
higher
entrapment
efficiency,
significantly
correlated
between
three
analytical
positively
data
confirmed
potential
this
cheaper
reliable
evaluate
efficiency
TTs
liposome
NLC
Conclusions:
results
recommend
using
liposomal
terpenoids
their
characterization
after
validation
HPLC-DAD.
also
offers
possibility
screening
short
time
different
recipes
stability
bioavailability,
which
is
useful
investigations
vitro
vivo,
may
confirm
efficacy
therapeutic
agents.
Язык: Английский