Advances in Alzheimer’s disease control approaches via carbon nanotubes
Nanomedicine,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Ноя. 28, 2024
Global
concern
about
Alzheimer's
disease
(AD)
is
justified
by
its
increasingly
younger
onset
and
significant
economic
burden.
AD
leads
to
neurodegeneration
cognitive
decline,
ultimately
resulting
in
loss
of
autonomy.
Against
this
background,
the
field
biomedical
research
has
seen
a
surge
interest
potential
carbon-based
nanomaterials,
mainly
due
their
ease
degradation
high
biocompatibility.
Carbon
nanotubes
(CNTs)
have
been
extensively
studied
AD,
including
developing
biosensors,
drug
delivery
systems,
molecular
imaging.
Here,
we
introduced
biosafety
biodegradability
CNTs,
with
particular
focus
on
uptake
brain
tissue.
The
utilization
CNT
context
therapy
can
facilitate
advancement
control
approaches
regimens
ensure
clinical
safety
patients.
This
achieved
through
employment
these
as
carriers
for
drugs
central
nervous
system
(CNS),
detection
neurotransmitters
such
acetylcholine
(Ach)
monoamines,
development
biosensors
imaging
materials,
inhibition
Aβ
formation
phosphorylated
tau
proteins,
promotion
CNS
regeneration,
modulation
ion-associated
AD.
Язык: Английский
Cholinesterase Inhibitory Activity of Paeoniflorin: Molecular Dynamics Simulation, and In Vitro Mechanistic Investigation
Biochemistry Research International,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Alzheimer’s
disease
(AD),
a
neurological
disorder,
is
one
of
the
major
reasons
for
memory
loss
in
world.
AD
characterized
by
sequela
cognitive
and
functional
decline
caused
brain
cell
degeneration.
Paeoniflorin
monoterpenoid
glycoside
found
plants
Paeoniaceae
family,
which
are
known
their
medicinal
properties
including
dementia.
In
this
project,
we
report
actions
paeoniflorin
on
two
related
cholinesterases
(ChE):
acetylChE
(AChE)
butyrylChE
(BuChE).
Paeoniflorin,
dose‐dependent
(maximum
inhibition
at
1
mg/mL)
manner,
inhibited
both
AChE
(0.06–1
BuChE
(0.007–1
enzymes
with
maximum
enzyme
90.3
±
1.4%,
while
99.4
0.3%
enzyme.
The
EC
50
value
inhibitory
effect
compound
against
was
0.52
mg/mL
(0.18–1.52),
0.13
(0.08–0.21).
observed
ani‐ChE
action
like
an
also
mediated
ChE
blocker
physostigmine.
Molecular
interactions
between
were
additionally
sought
via
molecular
docking
dynamics
simulations
100
ns,
that
showed
interacted
active‐site
gorge
hydrogen
bonds
water
bridging
many
amino
acids
enzymes.
This
study
presents
potential
With
kind
activity,
chemical
can
potentially
increase
ACh
levels
may
have
use
treatment
dementia
AD.
Язык: Английский