Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 4, 2025

With the consistent occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, prevalence various ocular complications has increased over time. SARS-CoV-2 infection been shown to have neurotropism and therefore lead not only peripheral inflammatory responses but also neuroinflammation. Because receptor for SARS-CoV-2, angiotensin-converting enzyme (ACE2), can be found in many intraocular tissues, disease 2019 (COVID-19) may contribute persistent neuroinflammation, microcirculation dysfunction symptoms. Increased awareness neuroinflammation future research on interventional strategies are important improving long-term outcomes, reducing burden, quality life. Therefore, aim this review is focus discuss current evidence perspectives, especially possible connections between conditions potential treatment strategies.

Язык: Английский

---

Immune checkpoints: new insights into the pathogenesis of thyroid eye disease

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 16, 2024

Thyroid eye disease (TED) is a disfiguring autoimmune characterized by changes in the orbital tissues and caused abnormal thyroid function or thyroid-related antibodies. It ocular manifestation of Graves' disease. The expression thyroid-stimulating hormone receptor (TSHR) insulin-like growth factor-1 (IGF-1 R) on cell membrane fibroblasts (OFs) responsible for TED pathology. Excessive inflammation when these receptors orbit are stimulated autoantibodies. CD34

Язык: Английский

---

More antibodies are not always better: Fc effector functions play a critical role in SARS-CoV-2 infection and protection

Progress in molecular biology and translational science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

---

Homocysteine stimulates orbital fibroblast proliferation and migration in Graves' orbitopathy via activating Akt signaling pathway

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер unknown, С. 151890 - 151890

Опубликована: Апрель 1, 2025

Язык: Английский

---

Thyroid eye disease (Graves' orbitopathy): clinical presentation, epidemiology, pathogenesis, and management

The Lancet Diabetes & Endocrinology, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

---

SARS-CoV-2 Affects Thyroid and Adrenal Glands: An 18F-FDG PET/CT Study

Biomedicines, Год журнала: 2023, Номер 11(11), С. 2899 - 2899

Опубликована: Окт. 26, 2023

Since most endocrine glands express ACE-2 receptors and can be infected by SARS-CoV-2 virus, this retrospective multicentre observational study aims to assess the metabolic activity of thyroid adrenal COVID-19 patients 18F-FDG PET/CT.We retrospectively evaluated PET/CT scans admitted three different centres, either in a low-intensity department or intensive care unit (ICU). A visual assessment semi-quantitative evaluation areas interest were performed recording SUVmax SUVmean. The uptake was compared with those observed normal age-matched controls.Between March 2020 2022, 33 from centres (twenty-eight five ICU), studied during active illness. Seven them also after clinical remission (3-6 months disease onset). Thirty-six subjects used as controls. In gland, no statistically significant differences between control at diagnosis. However, follow-up study, we found higher SUVmean (p = 0.009 p 0.004, respectively) patients. glands, lower baseline < 0.0001) finding did not normalize recovery 0.0018 for 0.002 SUV mean).In our series, persistent low diagnosis recovery, suggesting chronic hypofunction. By contrast, comparable onset, but subgroup showed an increased metabolism, thus possibly onset inflammatory thyroiditis. Our results should alert clinicians investigate pituitary-adrenal axis functionality time infection monitor recovery.

Язык: Английский

---

Letter to the Editor From Lui et al: “Increased Risk of Thyroid Eye Disease Following COVID-19 Vaccination”

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2023, Номер 109(3), С. e1315 - e1315

Опубликована: Окт. 17, 2023

Journal Article Letter to the Editor From Lui et al: "Increased Risk of Thyroid Eye Disease Following COVID-19 Vaccination" Get access David Tak Wai Lui, Department Medicine, School Clinical Li Ka Shing Faculty The University Hong Kong, Kong SAR, China Correspondence: MBBS, 102 Pokfulam Rd, Pokfulam, China. Email: [email protected]. https://orcid.org/0000-0002-9813-1126 Search for other works by this author on: Oxford Academic Google Scholar Carlos King Ho Wong, Wong Laboratory Data Discovery Health (D24H), ChinaDepartment Family Medicine and Primary Care, ChinaCentre Safe Medication Practice Research, Pharmacy Pharmacology, https://orcid.org/0000-0002-6895-6071 Kenneth K C Man ChinaResearch Policy, UCL Pharmacy, London WC1H 9JP, UKCentre Medicines Optimisation Research Education, College Hospitals NHS Foundation Trust, NW1 2PB, UK https://orcid.org/0000-0001-8645-1942 Endocrinology & Metabolism, Volume 109, Issue 3, March 2024, Page e1315, https://doi.org/10.1210/clinem/dgad614 Published: 17 October 2023 history Received: 18 September Editorial decision: 25 Corrected typeset:

Язык: Английский

---

Importance of Examining Incidentality in Vaccine Safety Assessment

Vaccines, Год журнала: 2024, Номер 12(5), С. 555 - 555

Опубликована: Май 18, 2024

The author believes that the principles of statistical methods for vaccine safety can be divided into three categories: comparison adverse event incidence rates between vaccinated and unvaccinated groups, analysis incidentality in group, a combination both. first category includes cohort study; second, self-controlled risk interval design (SCRI); third, case series method. A single p-value alone should not determine scientific conclusion, performed using multiple with different principles. both study SCRI is best method to assess safety. When may detect significant difference owing low rate an group or high one it. Because vaccines must have higher level than pharmaceuticals used treatment, advisable assessed even any value event. analyses COVID-19 areas improvement because proportion papers was negligible.

Язык: Английский

---

COVID-19 vaccination might be associated with asymmetric thyroid eye disease

Thyroid Science, Год журнала: 2024, Номер 1(4), С. 100019 - 100019

Опубликована: Авг. 7, 2024

The influence of COVID-19 vaccination on thyroid eye disease (TED) is unknown. We investigated the characteristics COVID-19-vaccinated TED. Sixty-two consecutive patients diagnosed with active TED were divided as follows. Patients from 2014 to 2019 defined pre-COVID-19 (n = 32). during pandemic (2020–2023) into 16) or without 14) before onset. Magnetic resonance images evaluated using number involved extraocular muscles (n-EOM), maximum signal intensity ratio (SIR max) and inferior rectus (IR) muscle area. Additionally, more enlarged IR area SIR max by that other side was calculated (IR ratio, ratio). symmetry also based ratios. Although, in affected orbit, n-EOM no significant difference, vaccinated showed fewer less orbit. significantly higher than others ratio; 1.07, 1.16, 1.42, 1.52, 1.38, 2.12, pre-COVID-19, non-vaccinated, vaccinated, respectively). When asymmetric 2 greater, proportion (50 %) (pre-COVID-19; 13 %, non-vaccinated; 14 %). In IR, regression line between Thyroid-stimulating antibody located lower those vaccination. After treatment, improved difference groups disappeared. asymmetry. Importantly, involvement reversible treatment.

Язык: Английский

---

Graves’ orbitopathy

Elsevier eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

---