Comparison of the lower genital tract microbiome composition in patients with benign gynecological disease

Frontiers in Global Women s Health, Год журнала: 2025, Номер 6

Опубликована: Янв. 21, 2025

Objective Lower genital tract microbiome dysbiosis has been associated with several gynecological diseases. However, the differences in composition among patients diseases, such as endometrial polyps and uterine myoma, are poorly understood. Studying lower benign diseases could provide new insights for interpreting complex interplay between pathogenesis finding targets preventive measures. Methods A total of 16 (EPs), 11 myoma (UM), 6 ovarian cysts (OC) 36 healthy women (HWs) were recruited this study. Samples obtained from vaginal secretions. The DNA was isolated samples, V3-V4 regions amplified. sequencing libraries generated sequenced on an Illumina NovaSeq 6000 platform. Results Firmicutes, Actinobacteria Bacteroidota most common phyla all four groups, whereas OC presented highest abundance Firmicutes lowest Bacteroidota. At genus level, Lactobacillus group significantly greater than that HW group, Atopobium UM group. Gardnerella EP Streptococcus richness evenness generally consistent HW, EP, UM, groups. Principal component analysis (PCA), principal coordinate (PCoA) nonmetric multidimensional scaling (NMDS) revealed no distinct separation trends According to ANOSIM, there significant difference community structure Conclusions nonsignificant result diversity comparison different we demonstrated had a Atopobium, which might contribute occurrence providing clues

Язык: Английский

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Licochalcone A Induces Uterine Leiomyoma Cell Apoptosis via the ROS-Mediated JNK Activation of the GRP78/NRF2 Pathway In Vitro and In Vivo

Antioxidants, Год журнала: 2025, Номер 14(2), С. 148 - 148

Опубликована: Янв. 27, 2025

Licochalcone A (LicoA) possesses anti-tumor properties. However, the potential therapeutic effect of LicoA on uterine leiomyomas (ULs) remains unknown. In this study, effects proliferation ULs and its underlying mechanism were explored. treatment significantly decreased viability smooth muscle cells (UtSMCs) ELT3 in a dose-dependent manner. The induction cell apoptosis by was accompanied increased generation reactive oxygen species (ROS), elevated endoplasmic reticulum (ER) stress (GRP78/IRE1α/ATF6/CHOP), expression proapoptotic proteins (c-caspase-3, c-caspase-9, c-PARP). ability Z-VAD-FMK (a caspase inhibitor) n-acetylcysteine (NAC; membrane permeable antioxidant) to reverse LicoA-induced ROS-mediated ER pathways also observed. Furthermore, GRP78 or JNK knockdown involved cells. immunodeficient mice, suppressed growth tumor cells, without toxicity. This study is first show that exerts anti-leiomyoma via modulation stress-induced through JNK/GRP78/NRF2 signaling pathway.

Язык: Английский

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The influence of uterine leiomyomatosis on the onset of psoriasis: a nationwide population-based study of 2.5 million Korean females

BMC Women s Health, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 5, 2025

Abstract Background Uterine leiomyomatosis and psoriasis are prevalent conditions shared pathophysiological factors indicate a potential association. However, direct correlation has not been established. We investigated the relationship between uterine risk of new-onset in Korean females reproductive age. Methods This nationwide population-based study used data from National Health Insurance System database. Data 2,755,790 20–39 years age who underwent health check-ups 2009 to 2012 were analyzed. Monitoring began at initial national assessment within time frame continued until either diagnosis emerging or December 2018. Results Among 2,503,769 included, 1.96% diagnosed with 0.72% leiomyomatosis. The incidence ratio for was higher patients (3.13 per 1,000) than subjects without (2.72 1,000). hazard occurrence 1.18 (1.07–1.31) patients, 1.22 (1.08–1.37) did undergo myomectomy, 1.12 (0.94–1.33) myomectomy. Conclusions especially those undergoing showed an increased psoriasis. Lifestyle modifications surgical intervention may also be beneficial occurrence.

Язык: Английский

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Management of a Uterine Fibroid Originating From a Rudimentary Horn in a Patient With Mayer-Rokitansky-Küster-Hauser Syndrome: Report of a Rare Case

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome involves complete or partial agenesis of the female reproductive tract, leading to impaired menstruation and reproduction, even clinical symptoms in certain cases. The absence an anatomically intact tract usually misleads clinicians ignore possibility that common gynecological conditions may develop MRKH patients, which is a rare but plausible scenario. In present report, we case 49-year-old patient with uterine fibroid developing from rudimentary tissue, one only few similar instances reported medical literature. patient, scheduled undergo oophorectomy due suspicious ovarian cyst being perimenopausal, decided total laparoscopic en bloc excision ovaries, salpinges, rudiments, fibroid, cyst. surgery was successful made swift, uneventful recovery. This report adds limited knowledge benign mesenchymal tumors arising mere remnants myometrium affirms need for vigilance during care patients.

Язык: Английский

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Association between blood heavy metals exposure with uterine fibroids among American women: a cross-sectional analysis from NHANES data

BMC Women s Health, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 18, 2025

Excessive exposure to heavy metals has been linked various health problems, including organ damage, neurological disorders, and reproductive developmental abnormalities. However, the relationship between uterine fibroids remains uncertain. To explore this association, we conducted a cross-sectional study among American women. We utilized data from three cycles of National Health Nutrition Examination Survey (NHANES, 1999–2006) evaluate association blood metal levels, lead (Pb), cadmium (Cd), mercury (Hg). Weighted logistic regression, restricted cubic spline (RCS), Bayesian kernel machine regression (BKMR), subgroup analyse were used examine potential relationships fibroids. Of 4502 women studied, 542 (12.04%) had Elevated levels all significantly more common in with (P < 0.001). Blood Hg notably associated fibroid prevalence adjusted model (OR = 1.41, 95% CI: 1.06–1.89, p 0.03). Similar patterns partly observed for Pb Cd. Age marital status significant interaction factors concerning 0.05). A dose-response an inflection point at 7µmol/L was identified Hg, BKMR models indicated positive mixed risk. Exposure metals, particularly is elevated risk Further prospective studies are necessary confirm these findings.

Язык: Английский

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