European Archives of Oto-Rhino-Laryngology, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Nutrients, Год журнала: 2025, Номер 17(2), С. 277 - 277
Опубликована: Янв. 14, 2025
Vitamin D offers numerous under-recognized health benefits beyond its well-known role in musculoskeletal health. It is vital for extra-renal tissues, prenatal health, brain function, immunity, pregnancy, cancer prevention, and cardiovascular Existing guidelines issued by governmental organizations are bone-centric largely overlook the abovementioned extra-skeletal optimal thresholds vitamin D. In addition, they rely on randomized controlled trials (RCTs), which seldom show due to high baseline 25-hydroxyvitamin [25(OH)D] concentrations, moderate supplementation doses, flawed study designs. This review emphasizes findings from prospective cohort studies showing that higher 25(OH)D concentrations reduce risks of major diseases mortality, including pregnancy birth outcomes. Serum > 30 ng/mL (75 nmol/L) significantly lower disease mortality compared <20 ng/mL. With 25% U.S. population 60% Central Europeans having levels ng/mL, should be raised above achievable through daily with 2000 IU/day (50 mcg/day) D3, prevent deaths. Furthermore, a dose between 4000 6000 IU D3 achieve serum 40 70 would provide greater protection against many adverse Future recommendations integrate observational well-designed RCTs improve public personalized care.
Язык: Английский
Процитировано
11
Journal of Nutrition, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Frontiers in Nutrition, Год журнала: 2025, Номер 11
Опубликована: Янв. 7, 2025
Current evidence is inconsistent on whether vitamin D supplementation can prevent COVID-19 infection or improve its clinical outcomes. To better understand and look into the issue, we went through background knowledge of D, searched in Pubmed [by using key words title containing "randomized trial", "COVID-19", "vitamin (25-hydroxyvitamin cholecalciferol, calcidiol, calcifediol) supplementation"] for publications studies D/supplementation patients, especially those about randomized trials (RCTs). After reviewing these papers, did a short review pathophysiology COVID-19, summarized features 25 RCTs text tabulated table some features, commented, compared discussed differences between (for example, change serum 25-hydroxyvitamin concentration from nmol/L to ng/mL, making comparison easier). The take-home question that an important indicator effect correction but may not be reliable predicting outcomes COVID-19.
Язык: Английский
Процитировано
1
Nature Reviews Endocrinology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 4, 2025
Язык: Английский
Процитировано
1
The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2024, Номер 109(8), С. 1948 - 1954
Опубликована: Июнь 3, 2024
Abstract A long-held precept is that vitamin D supplementation primarily, if not exclusively, benefits individuals with low circulating 25-hydroxyvitamin (25[OH]D) concentrations at baseline. However, the most appropriate 25(OH)D threshold to distinguish unacceptably vs reliably adequate remains controversial. Such proposals have largely been based on observational studies, which provide less robust evidence compared randomized clinical trials (RCTs). Since Endocrine Society's first D–related guideline was published in 2011, several large RCTs published, and a newly commissioned development panel (GDP) prioritized 4 questions related harms of generally healthy levels below threshold. The GDP determined available trial does permit establishment thresholds specifically predict meaningful benefit supplementation. noted important limitations evidence, panel's overall certainty very low. Nonetheless, GDP's analyses judgments, Society no longer endorses its previously proposed definition “sufficiency” (ie, least 30 ng/mL [75 nmol/L]) or “insufficiency” greater than 20 [50 nmol/L] but lower nmol/L]). rationale for such subject this Guideline Communication.
Язык: Английский
Процитировано
8
Annals of Intensive Care, Год журнала: 2024, Номер 14(1)
Опубликована: Авг. 1, 2024
Abstract Background Inflammation is the hallmark of critical illness and triggers neuro-endocrine stress response an oxidative stress. Acute inflammation initially essential for patient’s survival. However, ongoing or exaggerated inflammation, due to persistent organ dysfunction, immune dysfunction poor resolution, associated subsequent hypermetabolism hypercatabolism that severely impact short long-term functional status, autonomy, as well health-related costs. Modulation thus tempting, with goal improve short- outcomes critically ill patients. Findings can be modulated by nutritional strategies (including timing enteral nutrition initiation, provision some specific macronutrients micronutrients, use probiotics) metabolic treatments. The most interesting seem n-3 polyunsaturated fatty acids, vitamin D, antioxidant micronutrients propranolol, given their safety, accessibility clinical use, benefits in studies context care. optimal doses, route administration are still unknown them. Furthermore, recovery phase not studied defined. Conclusion rationale modulation obvious, based on pathophysiology increasingly described effects pharmacological strategies. Regretfully, there isn’t always substantial proof from research regarding positive impacts directly brought about modulation. Some arguments come performed severe burn patients, but such results should transposed non-burn patients caution. Further needed explore how after a illness.
Язык: Английский
Процитировано
8
Pituitary, Год журнала: 2024, Номер 27(6), С. 955 - 969
Опубликована: Сен. 6, 2024
Язык: Английский
Процитировано
7
Nutrients, Год журнала: 2025, Номер 17(5), С. 783 - 783
Опубликована: Фев. 24, 2025
A global deficiency in vitamin D is now widely prevalent. Extensive scientific research has provided compelling evidence of the detrimental effects on skeletal system. Furthermore, supplementation not only helps prevent bone fractures but may also slow progression various conditions, such as diabetes, autoimmune disorders, and cardiovascular disease. Achieving optimal circulating levels can be challenging, particularly certain clinical scenarios. Moreover, effect varies depending factors body weight, pregnancy status, absorption capacity, metabolic rate, renal function. This review aims to explore which formulations are most effective specific contexts where reaching adequate straightforward.
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2153 - 2153
Опубликована: Фев. 27, 2025
Vitamin D has been widely studied for its implications on type 2 diabetes mellitus, a chronic condition characterized by insulin resistance, inflammation, and metabolic dysfunction. This review explores the molecular mechanisms underpinning vitamin D's effects glucose metabolism, adipogenesis, while assessing potential clinical applications in diabetes. In 1,25-dihydroxyvitamin D3 form, modulates various processes, affecting proinflammatory cytokines activating AMPK pathway, inhibiting mTOR signaling, promoting adipocyte differentiation. These enhance sensitivity reduce key contributors to this context, progression of prediabetes linked D, which limits pathological increases likelihood restoring normal state, crucial progression. Moreover, reported developing 15%, particularly doses higher than traditional recommendations bone health. Despite promising evidence, discrepancies study designs, serum measurements, population-specific factors highlight need standardized methodologies personalized approaches. conclusion, complementary therapeutic treating diabetes, revealing gaps research, such as optimal dosing long-term across populations. Future studies should integrate insights into practice optimize impact
Язык: Английский
Процитировано
1
The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2024, Номер unknown
Опубликована: Июнь 13, 2024
Journal Article Accepted manuscript Vitamin D deficiency and type 2 diabetes: the dangerous link between two modern pandemics Get access Luigi di Filippo, Filippo Institute of Endocrine Metabolic Sciences, San Raffaele Vita-Salute University IRCCS Hospital, Milan, Italy Address for correspondence: MD, Via Olgettina 60, 20132, Italy. [email protected] https://orcid.org/0009-0002-6117-0081 Search other works by this author on: Oxford Academic Google Scholar Andrea Giustina https://orcid.org/0000-0001-6783-3398 The Clinical Endocrinology & Metabolism, dgae390, https://doi.org/10.1210/clinem/dgae390 Published: 13 June 2024 history Received: 09 May Revision received: 20 Editorial decision: 01 Accepted: 06
Язык: Английский
Процитировано
6