Seminars in Cancer Biology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
BMC Endocrine Disorders, Год журнала: 2024, Номер 24(1)
Опубликована: Окт. 15, 2024
The presence of hypertension significantly increases the risk diabetes, particularly type 2 diabetes. Recently, Visceral Adiposity Index (VAI) has been introduced as a straightforward and robust alternative indicator for early detection metabolic syndrome, cardiovascular disease, T2DM. adiposity, more dangerous than subcutaneous fat, is associated with syndrome diseases. VAI Lipid Accumulation Product (LAP) are indices that quantify visceral fat lipid overaccumulation, respectively. This study aims to explore association between VAI, LAP, diabetes mellitus (T2DM) in US adults using NHANES data from 2005 2018.
Язык: Английский
Процитировано
4
International Journal of Women s Health, Год журнала: 2025, Номер Volume 17, С. 109 - 118
Опубликована: Янв. 1, 2025
Osteoporosis is a common health concern in postmenopausal women. Obesity, commonly assessed using body mass index (BMI), may have protective effect on osteoporosis As BMI limited to the distinguishing fat accumulation, study aimed explore association between allometric shape indices [including (ABSI), hip index, (HI), and waist-hip (WHI)] Postmenopausal women aged >50 years National Health Nutrition Examination Survey from 2017 through 2020 (revised 01/2017 12/2020) were included. Potential covariates selected univariate logistic regression models. The was explored weighted multivariate models, with results presented as odds ratios (ORs) 95% confidence intervals (CIs). further different age populations. Area under curve (AUC) analysis conducted evaluate predictive performance of WHI. In total, 810 Among them, 597 (73.70%) osteoporosis. WHI ≥0.094 (OR = 2.07, CI: 1.14-3.78) associated higher ≥30 kg/m2 0.23, 0.11-0.50) also related decreased ABSI ≥85.74 incidence ≥70 4.18, 1.22-14.35) 4.25, 1.82-9.95). has better an AUC 0.656 (95% 0.613-0.699) than ratio. Higher increased those kg/m2. could predict
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Фев. 3, 2025
Cellular aging is a multifactorial and intricately regulated physiological process with profound implications. The interaction between cellular senescence cancer complex multifaceted, can both promote inhibit tumor progression through various mechanisms. M6A methylation modification regulates the of cells tissues by modulating senescence-related genes. In this review, we comprehensively discuss characteristics senescence, signaling pathways regulating biomarkers mechanisms anti-senescence drugs. Notably, review also delves into interactions cancer, emphasizing dual role senescent microenvironment in initiation, progression, treatment. Finally, thoroughly explore function mechanism m6A revealing its critical gene expression maintaining homeostasis. conclusion, provides comprehensive perspective on molecular biological significance offers new insights for development strategies.
Язык: Английский
Процитировано
0
Mechanisms of Ageing and Development, Год журнала: 2025, Номер unknown, С. 112039 - 112039
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Biomolecules, Год журнала: 2025, Номер 15(2), С. 276 - 276
Опубликована: Фев. 13, 2025
Bone marrow mesenchymal stromal cells (BM-MSCs) are multipotent present in bone marrow; they play a crucial role the process of formation. Cellular senescence is defined as stable state cell cycle arrest that impairs functioning cells. Research has shown aging triggers BM-MSCs, leading to reduced capacity for osteogenic differentiation and accumulation senescent cells, which can accelerate onset various diseases. Therefore, it essential explore mechanisms strategies rejuvenation BM-MSCs. Senile osteoporosis (SOP) metabolic disease characterized by The BM-MSCs considered one most important factors occurrence development SOP. treatment SOP represents promising strategy. This work provides summary functional alterations observed systematic review facilitate Additionally, we analyze progress limitations associated with application rejuvenated treat SOP, aim providing new insights prevention
Язык: Английский
Процитировано
0
Animal Cells and Systems, Год журнала: 2025, Номер 29(1), С. 19 - 29
Опубликована: Март 12, 2025
Human periodontal ligament stem cells (hPDLSCs) are candidate seed for tissue regeneration. Enhancing the stemness maintenance and osteogenic differentiation potential of hPDLSCs is conducive to their role in The combination dasatinib quercetin, a type senolytic, has been reported affect cell senescence. However, whether it can regulate hPDLSCs, related mechanisms, remain unknown. present study analyzed optimal concentrations quercetin found that enhanced promoted expression stemness-related markers hPDLSCs. levels TAZ YAP were improved when incubated with quercetin. osteogenesis-promoting effects plus partly attenuated was knocked down, on suppressed inhibited. Taken together, promotes YAP/TAZ may be involved this process. This hold promise improving function
Язык: Английский
Процитировано
0
Advances in pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177574 - 177574
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Bone, Год журнала: 2025, Номер unknown, С. 117485 - 117485
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 9, 2025
Abstract Osteoporosis is characterized by an imbalance between osteoblasts and osteoclasts coupling excessive oxidative stress in the bone microenvironment that impairs defect healing increases risk of non‐union. In this study, injectable gypsogenin (GN)‐based organic–inorganic composite hydrogel (CCT/nHA@GN) developed to treat osteoporotic defects. The made grafting sodium citrate (SC) nano‐hydroxyapatite (nHA)/GN nanoparticles onto carboxymethylated chitosan (CMCS). GN a natural small‐molecule saponin, which shows biocompatibility anti‐oxidant properties. resulting well‐defined porous structure, favorable degradability, controlled drug‐release properties, suitable rheological characteristics. Importantly, it reverses differentiation fate marrow‐derived mesenchymal stem cells (BMSCs) from patients promotes angiogenesis human umbilical vein endothelial (HUVECs). Furthermore, activates AMPKα‐FOXO3a‐CAT/MnSOD signaling pathway via AMPKα phosphorylation, thereby augmenting antioxidant capacity, promoting osteogenesis, inhibiting osteoclastogenesis, ultimately rectifying disrupted microenvironment. vivo studies reveal volume total (BV/TV) ratio bones regenerated with CCT/nHA@GN 2.85 times higher than control group. conclusion, these findings suggest can be promising alternative material for treatment
Язык: Английский
Процитировано
0