Mitochondrial signal transduction

Cell Metabolism, Год журнала: 2022, Номер 34(11), С. 1620 - 1653

Опубликована: Ноя. 1, 2022

The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue the processor cell, together with nucleus other they constitute mitochondrial information processing system (MIPS). In a three-step process, (1) sense respond to both endogenous environmental inputs through morphological functional remodeling; (2) integrate network-based physical interactions diffusion mechanisms; (3) produce output signals tune functions systemically regulate physiology. This input-to-output transformation allows metabolic, biochemical, neuroendocrine, local or systemic enhance organismal adaptation. An explicit focus on signal transduction emphasizes role communication in biology. framework also opens new avenues understand how mediate inter-organ processes underlying human health.

Язык: Английский

---

A brief review about melatonin, a pineal hormone

Archives of Endocrinology and Metabolism, Год журнала: 2018, Номер 62(4), С. 472 - 479

Опубликована: Авг. 1, 2018

Melatonin is a ubiquitous molecule in nature, being locally synthesized several cells and tissues, besides hormone that centrally produced the pineal gland of vertebrates, particularly mammals. Its synthesis timed by suprachiasmatic nucleus, synchronized to light-dark cycle via retinohypothalamic tract, placing melatonin at night, provided its dark. This unique trait turns into an internal synchronizer adequately times organism's physiology daily seasonal demands. Besides amphiphilic, presents specific mechanisms ways action devoted role as time-giving agent, widely spread organism. The present review aims focus on with action, presenting clinical syndromes related and/or function disruptions.

Язык: Английский

---

Mitophagy in degenerative joint diseases

Autophagy, Год журнала: 2020, Номер 17(9), С. 2082 - 2092

Опубликована: Сен. 24, 2020

Mitochondrial dysfunction is involved in aging and multiple degenerative diseases, including intervertebral disc degeneration (IVDD) osteoarthritis (OA). Thus, the maintenance of mitochondria homeostasis function important. Mitophagy, a process that selectively clears damaged or dysfunctional through autophagic machinery, functions to maintain mitochondrial quality control homeostasis. IVDD OA are similar joint diseases involving degradation cartilaginous tissues mainly caused by oxidative stress, cell apoptosis extracellular matrix (ECM) degradation. Over past decade, accumulating evidence indicates essential role mitophagy pathogenesis OA. Importantly, strategies regulation exert beneficial effects pre-clinical experiments. Given importance novelty mitophagy, we provide an overview pathways discuss roles We also highlight potential targeting for treatment diseases.Abbreviations: AD: Alzheimer disease; AF: annulus fibrosus; ADORA2A/A2AR: adenosine A2a receptor; AMBRA1: autophagy beclin 1 regulator 1; BMSCs: bone marrow mesenchymal stem cells; BNIP3: BCL2 interacting protein 3; BNIP3L/NIX: BCL2/adenovirus E1B 3-like; CDH6: cadherin 6; CEP: endplates; circRNA: circular RNA; DNM1L/DRP1: dynamin 1-like; ECM: matrix; HIF1A: hypoxia inducible factor 1: alpha subunit; IL1B: interleukin beta; IMM: inner membranes; IVDD: degeneration; MAPK8/JNK: mitogen-activated kinase 8; MFN1: mitofusin MFN2: 2; MIA: monosodium iodoacetate; RHOT/MIRO: ras homolog family member T; MMP: transmembrane potential; CALCOCO2/NDP52: calcium binding coiled-coil domain NFE2L2: nuclear factor: erythroid 2 like NP: nucleus pulposus; OA: osteoarthritis; OPA1: GTPase; OPTN: optineurin; PRKN: parkin RBR E3 ubiquitin ligase; PD: Parkinson PGAM5: PGAM 5; PPARGC1A/PGC-1A: peroxisome proliferator activated receptor: gamma: coactivator alpha; PHF23: PHD finger 23; PINK1: PTEN induced putative ROS: reactive oxygen species; SfMSCs: synovial fluid MSCs; SIRT1: sirtuin SIRT2: SIRT3: SQSTM1/p62: sequestosome TNF: tumor necrosis factor; Ub: ubiquitin; UBL: ubiquitin-like; VDAC: voltage-dependent anion channel.

Язык: Английский

---

The Role of Neuroinflammation in Postoperative Cognitive Dysfunction: Moving From Hypothesis to Treatment

Frontiers in Psychiatry, Год журнала: 2019, Номер 9

Опубликована: Янв. 17, 2019

Postoperative cognitive dysfunction (POCD) is a common complication of the surgical experience and in elderly patients with preexisting neurocognitive disorders. Animal human studies suggest that neuroinflammation from either surgery or anesthesia major contributor to development POCD. Moreover, large growing body literature has focused on identifying potential risk factors for POCD, as well candidate treatments based neuroinflammatory hypothesis. However, variability animal models clinical cohorts makes it difficult interpret results such studies, represents barrier treatment options Here, we present broad topical review supporting role We provide an overview cellular molecular mechanisms underlying pathogenesis POCD pre-clinical studies. offer brief discussion ongoing debate root cause conclude list current hypothesized focus recent randomized trials.

Язык: Английский

---

Melatonin and Health: Insights of Melatonin Action, Biological Functions, and Associated Disorders

Cellular and Molecular Neurobiology, Год журнала: 2023, Номер 43(6), С. 2437 - 2458

Опубликована: Фев. 8, 2023

Язык: Английский

---

Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions

Journal of Pharmacokinetics and Pharmacodynamics, Год журнала: 2021, Номер 48(3), С. 321 - 338

Опубликована: Апрель 1, 2021

Язык: Английский

---

Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 157, С. 114048 - 114048

Опубликована: Дек. 1, 2022

Cataracts are the main cause of reversible blindness worldwide. The ageing lens caused by ultraviolet B (UVB) radiation is mostly related to oxidative stress (OS). Little known about whether OS induced UVB enhances sensitivity epithelial cells ferroptotic stress, which may be a new mechanism leading age-related cataracts (ARCs).Ferroptosis was detected transmission electron microscopy (TEM), iron assay, lipid peroxidation (MDA) real-time PCR, western blotting, and immunofluorescence. Genetic engineering technology used investigate regulatory relationship among Sirtuin 6 (SIRT6), nuclear factor erythroid 2-related 2 (Nrf2), receptor coactivator 4 (NCOA4), glutathione peroxidase (GPX4) ferritin heavy chain (FTH1). Knockdown overexpression SIRT6 locally in vivo rats were performed probe ferroptosis ARCs.Here, we observed that can drastically induce vitro. Surprisingly, inhibition direct reason melatonin rescued B-3, SRA01/04 HEK-293 T survival; pan-caspase inhibitor Z-Vad-FMK did not significantly reverse death UVB-irradiated compared with UVB+DMSO group. an upstream regulator phosphorylated Nrf2 (p-Nrf2) NCOA4 cells. Melatonin inhibited through SIRT6/p-Nrf2/GPX4 SIRT6/COA4/FTH1 pathways neutralize toxicity, protected against vitro delayed cataract formation exposure rats.Our findings reveal novel causal role pathogenesis ARCs, raises possibility selectively targeting activation resistance as latent antioxidative therapeutic strategy for ARCs.

Язык: Английский

---

Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3392 - 3392

Опубликована: Фев. 8, 2023

Availability of artificial light and light-emitting devices have altered human temporal life, allowing 24-hour healthcare, commerce production, expanding social life around the clock. However, physiology behavior that evolved in context 24 h solar days are frequently perturbed by exposure to at night. This is particularly salient circadian rhythms, result endogenous biological clocks with a rhythm ~24 h. Circadian rhythms govern features behavior, set precisely primarily during day, though other factors, such as timing meals, can also affect rhythms. significantly affected night shift work because nocturnal light, electronic devices, shifts meals. Night workers increased risk for metabolic disorder, well several types cancer. Others who exposed or late mealtimes show disrupted cardiac disorders. It imperative understand how alter function develop strategies mitigate their negative effects. In this review, we provide an introduction physiological regulation homeostasis suprachiasmatic nucleus (SCN), SCN-mediated hormones display including melatonin glucocorticoids. Next, discuss circadian-gated processes sleep food intake, followed modern lighting disrupts molecular clock Lastly, identify disruptions metabolism increase susceptibility syndrome cardiovascular diseases, various harmful consequences associated on health.

Язык: Английский

---

Advanced postoperative tissue antiadhesive membranes enabled with electrospun nanofibers

Biomaterials Science, Год журнала: 2024, Номер 12(7), С. 1643 - 1661

Опубликована: Янв. 1, 2024

Electrospun nanofibers with fascinating properties provide a versatile platform for postoperative tissue anti-adhesion.

Язык: Английский

---

Antioxidant Actions of Melatonin: A Systematic Review of Animal Studies

Antioxidants, Год журнала: 2024, Номер 13(4), С. 439 - 439

Опубликована: Апрель 7, 2024

Melatonin is an indoleamine with crucial antioxidant properties that are used to combat inflammatory and neoplastic processes, as well control transplants. However, the clinical applications of melatonin have not yet been fully consolidated in literature require in-depth analysis. Objectives: This study reviewed on rat models. Methods: We followed guidelines Preferred Reporting Items for Systematic Reviews Meta-analyses PubMed, LILACS, Cochrane databases, Google Scholar, article references, irrespective publication time. Results: Ten articles involving 485 rats were selected, effects markers investigated. increased superoxide dismutase nine studies, glutathione peroxidase seven catalase five studies. In contrast, reduced three studies malonaldehyde eight Conclusion: Our findings suggest effectively reduces oxidative stress.

Язык: Английский

---