Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila DOI Creative Commons
Zhixin Ma, Wenshu Wang, Xiaojing Yang

и другие.

eLife, Год журнала: 2024, Номер 13

Опубликована: Сен. 10, 2024

Stem cell niche is critical for regulating the behavior of stem cells. Drosophila neural cells (Neuroblasts, NBs) are encased by glial closely, but it still remains unclear whether can regulate self-renewal and differentiation NBs. Here, we show that ferritin produced glia, cooperates with Zip13 to transport iron into NBs energy production, which essential proliferation The knockdown encoding genes causes shortage in via downregulating aconitase activity NAD + level, leads low premature mediated Prospero entering nuclei. More importantly, a potential target tumor suppression. In addition, level production affected status NBs, establishing bicellular homeostasis. this study, demonstrate indispensable maintain unveiling novel role NB during brain development.

Язык: Английский

An interplay between cellular growth and atypical fusion defines morphogenesis of a modular glial niche DOI Open Access
Maria A. Rujano, David Briand,

Bojana Ðelić

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2021, Номер unknown

Опубликована: Май 10, 2021

Abstract Neural stem cells (NSCs) are embedded in a multi-layered, intricate cellular microenvironment supporting their activity, the niche. Whilst shape and function inseparable, morphogenetic aspects of niche development poorly understood. Here, we use formation glial network NSC to investigate acquisition architectural complexity. Cortex glia (CG) Drosophila regulate neurogenesis build reticular structure around NSCs. We first show that individual CG grow tremendously ensheath several lineages, eventually spanning entire tissue while partitioning population. Elaborate proliferative mechanisms convert these into syncytia rich cytoplasmic bridges. Unexpectedly, further undergo homotypic cell-cell fusion, relying on defined molecular players cell fusion such as surface receptors actin regulators. Exchange components is however dynamic space time, previously unreported unique mechanism. This atypical remodels borders, restructuring syncytia. Ultimately, coordination growth builds multi-level architecture niche, creates modular, spatial partition Our findings provide novel insights how forms organises developing intimate contacts with

Язык: Английский

Процитировано

3
Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila DOI Open Access
Zhixin Ma, Wenshu Wang, Xiaojing Yang

и другие.

Опубликована: Март 4, 2024

Stem cell niche is critical for regulating the behavior of stem cells. Drosophila neural cells (Neuroblasts, NBs) are encased by glial closely, but it still remains unclear whether can regulate self-renewal and differentiation NBs. Here we show that ferritin produced glia, cooperates with Zip13 to transport iron into NBs energy production, which essential proliferation The knockdown encoding genes causes shortage in NBs, leads low premature Moreover, level production affected status establishing a bicellular homeostasis. In this study, demonstrate indispensable maintain unveiling novel role NB during brain development.

Язык: Английский

Процитировано

0
Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila DOI Open Access
Zhixin Ma, Wenshu Wang, Xiaojing Yang

и другие.

Опубликована: Авг. 9, 2024

Stem cell niche is critical for regulating the behavior of stem cells. Drosophila neural cells (Neuroblasts, NBs) are encased by glial closely, but it still remains unclear whether can regulate self-renewal and differentiation NBs. Here we show that ferritin produced glia, cooperates with Zip13 to transport iron into NBs energy production, which essential proliferation The knockdown encoding genes causes shortage in via downregulating aconitase activity NAD + level, leads low premature mediated Prospero entering nuclei. More importantly, a potential target tumor suppression. In addition, level production affected status NBs, establishing bicellular homeostasis. this study, demonstrate indispensable maintain unveiling novel role NB during brain development.

Язык: Английский

Процитировано

0
Glia multitask to compensate for neighboring glial cell dysfunction DOI Creative Commons

Allison N. Beachum,

Gabriela Salazar,

Amelia Nachbar

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

As glia mature, they undergo glial tiling to abut one another without invading each other's boundaries. Upon the loss of secreted neurotrophin Spätzle3 (Spz3),

Язык: Английский

Процитировано

0
Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila DOI Creative Commons
Zhixin Ma, Wenshu Wang, Xiaojing Yang

и другие.

eLife, Год журнала: 2024, Номер 13

Опубликована: Сен. 10, 2024

Stem cell niche is critical for regulating the behavior of stem cells. Drosophila neural cells (Neuroblasts, NBs) are encased by glial closely, but it still remains unclear whether can regulate self-renewal and differentiation NBs. Here, we show that ferritin produced glia, cooperates with Zip13 to transport iron into NBs energy production, which essential proliferation The knockdown encoding genes causes shortage in via downregulating aconitase activity NAD + level, leads low premature mediated Prospero entering nuclei. More importantly, a potential target tumor suppression. In addition, level production affected status NBs, establishing bicellular homeostasis. this study, demonstrate indispensable maintain unveiling novel role NB during brain development.

Язык: Английский

Процитировано

0