médecine/sciences, Год журнала: 2024, Номер 40(8-9), С. 620 - 622
Опубликована: Авг. 1, 2024
Development, Год журнала: 2024, Номер 151(15)
Опубликована: Авг. 1, 2024
Changes in gene dosage can have tremendous evolutionary potential (e.g. whole-genome duplications), but without compensatory mechanisms, they also lead to dysregulation and pathologies. Sex chromosomes are a paradigmatic example of naturally occurring differences their compensation. In species with chromosome-based sex determination, individuals within the same population necessarily show 'natural' for chromosomes. this Review, we focus on mammalian X chromosome discuss recent new insights into dosage-compensation mechanisms that evolved along emergence chromosomes, namely X-inactivation X-upregulation. We evolution genetic loci molecular players involved, as well regulatory diversity potentially different requirements compensation across species.
Язык: Английский
Процитировано
5
Current Opinion in Oncology, Год журнала: 2024, Номер 36(2), С. 74 - 81
Опубликована: Янв. 2, 2024
Purpose of review Cellular dormancy is a major contributor to cancer progression and recurrence. This explores recent findings on the molecular mechanisms implicated in investigates potential strategies improve therapeutic interventions. Recent Research reveals complex multifaceted phenomenon. Providing latent reservoir tumor cells with reduced proliferation enhanced drug-tolerance, dormant emerge from clonally diverse population after therapy or at metastatic sites. These exhibit distinct transcriptional epigenetic profiles, involving downregulation Myc mechanistic target rapamycin (mTOR) pathways, induction autophagy. Senescence traits, under control factors such as p53, also contribute significantly. The microenvironment can either promote prevent establishment, notably through involvement T NK within niche. Strategies combat dormancy-related relapse include direct elimination cells, sustaining prolong survival, awakening re-sensitize them antiproliferative drugs. Summary Improving our understanding primary secondary sites provides valuable insights into patient care prevention.
Язык: Английский
Процитировано
3
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Авг. 22, 2023
SUMMARY Developing mammalian brains are characterized by disproportionate growth of the forebrain compared to other regions. How this localized expansion occurs is, however, largely unknown. To address this, we identified region-specific neurogenic patterns creating a single-cell-resolution birthdate atlas mouse brain ( https://www.neurobirth.org ). We report that in regions, neurogenesis is sustained hindbrain, where transient and limited early development. Sustained reflects lengthened cell cycle reduced consumptive divisions ventricular zone progenitors, resulting preserved germinal pool. Using single-cell RNA sequencing, identify functional molecular programs progenitors spatially temporally regulate progenitor cycling properties, including through loss-of-function forebrain-enriched mitochondrial membrane protein Fam210b. These results reveal parsimonious mechanism locally neuronal production, which time window during generate cells critical determinant expansion.
Язык: Английский
Процитировано
8
Current Opinion in Genetics & Development, Год журнала: 2024, Номер 86, С. 102178 - 102178
Опубликована: Март 11, 2024
Язык: Английский
Процитировано
2
BMC Genomics, Год журнала: 2024, Номер 25(1)
Опубликована: Ноя. 21, 2024
Abstract Background Z-DNA, a left-handed helical form of DNA, plays significant role in genomic stability and gene regulation. Its formation, associated with high GC content repetitive sequences, is linked to instability, potentially leading large-scale deletions contributing phenotypic diversity evolutionary adaptation. Results In this study, we analyzed the density Z-DNA-prone motifs 154 avian genomes using non-B DNA Motif Search Tool (nBMST). Our findings indicate higher prevalence Z-DNA promoter regions across all species compared other regions. A negative correlation was observed between developmental time birds, suggesting that shorter periods tend have densities. This relationship implies may influence timing regulation development species. Furthermore, showed associations traits such as body mass, egg genome size, highlighting complex interactions architecture characteristics. Gene Ontology (GO) analysis revealed are enriched genes involved nucleic acid binding, kinase activity, translation regulation, fine-tuning expression essential for cellular functions responses environmental changes. Additionally, potential drive instability facilitate adaptive evolution underscores its importance shaping diversity. Conclusions study emphasizes dynamic element stability, Future research should experimentally validate these explore molecular mechanisms by which influences biology.
Язык: Английский
Процитировано
1
médecine/sciences, Год журнала: 2024, Номер 40(8-9), С. 620 - 622
Опубликована: Авг. 1, 2024
Процитировано
0