Metabolites,
Год журнала:
2023,
Номер
13(12), С. 1184 - 1184
Опубликована: Дек. 5, 2023
The
field
of
human
microbiome
and
gut
microbial
diversity
research
has
witnessed
a
profound
transformation,
driven
by
advances
in
omics
technologies.
These
advancements
have
unveiled
essential
connections
between
alterations
severe
conditions,
prompting
the
development
new
frameworks
through
epidemiological
studies.
Traditionally,
it
was
believed
that
each
individual
harbored
unique
communities
acquired
early
life,
evolving
over
course
their
lifetime,
with
little
acknowledgment
any
prenatal
development,
but
recent
challenges
this
belief.
neonatal
microbiome’s
onset,
influenced
factors
like
delivery
mode
maternal
health,
remains
subject
intense
debate,
hinting
at
potential
intrauterine
processes.
In-depth
reveals
associations
profiles
specific
health
outcomes,
ranging
from
obesity
to
neurodevelopmental
disorders.
Understanding
these
diverse
is
for
unraveling
intricate
relationships
outcomes.
Trends in Endocrinology and Metabolism,
Год журнала:
2024,
Номер
35(7), С. 638 - 647
Опубликована: Фев. 28, 2024
The
obesity
epidemic
has
led
to
a
growing
body
of
research
investigating
the
consequences
maternal
on
pregnancy
and
offspring
health.
placenta,
traditionally
viewed
as
passive
intermediary
between
mother
fetus,
is
known
play
critical
role
in
modulating
intrauterine
environment
fetal
development,
we
now
know
that
leads
increased
inflammation,
oxidative
stress,
altered
placental
function.
Here,
review
recent
exploring
involvement
inflammation
stress
mechanisms
impacting
placenta
fetus
during
obese
pregnancy.
Understanding
them
crucial
for
informing
strategies
can
mitigate
adverse
health
effects
development
disease
risk.
Cell Reports,
Год журнала:
2025,
Номер
44(3), С. 115433 - 115433
Опубликована: Март 1, 2025
Sex
steroid
hormones
such
as
progesterone
play
a
pivotal
role
in
reproductive
functions
and
maintaining
pregnancy;
however,
the
impact
of
on
interaction
between
mother
embryo
is
unclear.
Here,
we
demonstrate
that
relationship
maternal
membrane
receptor
epsilon
(mPRε)
adipose
tissue
regulates
embryonic
nutritional
environment
growth
after
birth
mice.
The
activation
mPRε
by
increased
during
pregnancy
enhances
insulin
resistance
via
prostaglandin
production,
efficiently
providing
glucose
to
embryos.
Correspondingly,
offspring
mPRε-deficient
mothers
exhibited
metabolic
dysfunction,
whereas
with
high-fat
diet-induced
obesity
improved
sensitivity.
These
findings
establish
importance
regulator
embryo.
Additionally,
may
represent
modulator
for
treating
pregnant
glycemic
control
disorders
gestational
diabetes
mellitus,
well
syndrome
offspring.
Frontiers in Veterinary Science,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 28, 2025
Appropriate
nutritional
strategies
show
promise
for
enhancing
productive
performance
and
longevity
of
sows.
This
study
aimed
to
determine
the
effects
increased
energy
amino
acids
(AA)
intake
during
gestation
on
reproductive
performance,
milk
composition,
blood
parameters,
placental
nutrient
transport
antioxidant
capacity
high-parity
A
total
72
Landrace
×
Yorkshire
sows
(seventh
ninth
parity)
were
randomly
assigned
dietary
treatments
consisting
combinations
2
levels
AA
in
a
factorial
design.
Blood
samples
placentas
from
collected
measure
biochemistry
indexes,
indicators
related
transport.
The
results
showed
that
fed
high
reduced
number
live
born
piglets
(p
<
0.05),
birth
weight
0.05).
Further
observation
decreased
plasma
progesterone
at
30
60
days
glutathione
peroxidase
(GPX)
superoxide
dismutase
(T-SOD)
90
fat
content
colostrum
average
daily
gain
lactation
Moreover,
mRNA
expression
GPX
glucose
transporter
3
placenta
High
tendency
increase
litter
protein
0.10),
urea
nitrogen
day
110
T-SOD
Furthermore,
expressions
extracellular
SOD
sodium-dependent
neutral
acid
1
In
conclusion,
feed
negatively
impacted
fetal
survival
by
reducing
concentrations
capacity,
while
simultaneously
increasing
piglet
through
enhanced
received
exhibited
better
redox
status
improved
which
can
be
attributed
enhancements
composition.
Acta Physiologica,
Год журнала:
2024,
Номер
240(7)
Опубликована: Май 6, 2024
Abnormal
fetal
growth,
i.e.,
intrauterine
growth
restriction
(IUGR)
or
(FGR)
and
overgrowth,
is
associated
with
increased
perinatal
morbidity
mortality
strongly
linked
to
the
development
of
metabolic
cardiovascular
disease
in
childhood
later
life.
Emerging
evidence
suggests
that
changes
placental
amino
acid
transport
may
contribute
abnormal
growth.
This
review
focused
on
human
placenta,
however,
relevant
animal
models
will
be
discussed
add
mechanistic
insights.
At
least
25
distinct
transporters
different
characteristics
substrate
preferences
have
been
identified
placenta.
Of
these,
System
A,
transporting
neutral
nonessential
acids,
L,
mediating
essential
studied
some
detail.
Importantly,
decreased
Systems
A
L
transporter
activity
IUGR
these
two
has
overgrowth
pregnancy.
An
array
factors
maternal
circulation,
including
insulin,
IGF-1,
adiponectin,
signaling
pathways
such
as
mTOR,
key
regulators
L.
Studies
using
trophoblast-specific
gene
targeting
mice
provided
compelling
are
mechanistically
altered
It
possible
specific
their
upstream
represents
a
novel
intervention
alleviate
short-
long-term
consequences
future.
Fermented
wheat
germ
improved
morphology,
alleviated
metabolic
disorders,
and
regulated
nutrient
transport
of
placenta
in
maternal
rats
with
obesity
induced
by
a
high-fat
diet.
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Март 11, 2025
Objective
This
study
speculates
that
gestational
diabetes
mellitus
(GDM)
may
reduce
fetal
telomere
length
(TL),which
be
related
to
modification
of
methylation
in
the
promoter
region
telomerase
(TE)
gene
region.
Methods
In
this
study,
umbilical
cord
blood
samples
from
patients
with
and
without
GDM
(N
=
100
each)
were
analyzed
by
prospective
case-control.
The
TL,
TE
expression
levels,
levels
TERT
TERC
regions
two
groups
measured.
significance
level
each
CpG
locus
employed
logistic
regression
analysis
R
software,
covariance
(ANCOVA)
was
used
control
influence
confounding
factors.
Correlation
performed
Spearman.
Results
TL
offspring
decreased
despite
adjusting
for
PBMI,
PWG,
TG.
A
total
islands
screened
three
fragments
(TERT_2,
TERT_3,
TERT_4)
containing
a
70
sites
designed.
Additionally,
four
group
(TERT_2_40,
TERT_2_47,
TERT_3_46,
TERT_3_212)
showed
increased
compared
(all
P
<
0.05).
gene,
one
island
19
loci
designed,
significantly
different
TERC_1_67
(0.65
±
0.21
versus
0.57
0.30;
0.040)
TERC_1_120
(0.68
0.23
0.59
0.27;
0.014).
higher
than
those
(0.69
0.06
0.65
0.08,
0.001).
Conclusion
revealed
induce
increasing
genes
region,
thereby
reducing
TL.
