From Mother to Infant, from Placenta to Gut: Understanding Varied Microbiome Profiles in Neonates DOI Creative Commons
Riadh Cheddadi, Venkata A. Yeramilli,

Colin Martin

и другие.

Metabolites, Год журнала: 2023, Номер 13(12), С. 1184 - 1184

Опубликована: Дек. 5, 2023

The field of human microbiome and gut microbial diversity research has witnessed a profound transformation, driven by advances in omics technologies. These advancements have unveiled essential connections between alterations severe conditions, prompting the development new frameworks through epidemiological studies. Traditionally, it was believed that each individual harbored unique communities acquired early life, evolving over course their lifetime, with little acknowledgment any prenatal development, but recent challenges this belief. neonatal microbiome’s onset, influenced factors like delivery mode maternal health, remains subject intense debate, hinting at potential intrauterine processes. In-depth reveals associations profiles specific health outcomes, ranging from obesity to neurodevelopmental disorders. Understanding these diverse is for unraveling intricate relationships outcomes.

Язык: Английский

Placental inflammation, oxidative stress, and fetal outcomes in maternal obesity DOI Creative Commons
Cindy X. W. Zhang,

Alejandro A. Candia,

Amanda N. Sferruzzi‐Perri

и другие.

Trends in Endocrinology and Metabolism, Год журнала: 2024, Номер 35(7), С. 638 - 647

Опубликована: Фев. 28, 2024

The obesity epidemic has led to a growing body of research investigating the consequences maternal on pregnancy and offspring health. placenta, traditionally viewed as passive intermediary between mother fetus, is known play critical role in modulating intrauterine environment fetal development, we now know that leads increased inflammation, oxidative stress, altered placental function. Here, review recent exploring involvement inflammation stress mechanisms impacting placenta fetus during obese pregnancy. Understanding them crucial for informing strategies can mitigate adverse health effects development disease risk.

Язык: Английский

Процитировано

26

Transplacental signals involved in the programming effects of prenatal psychosocial stress on neurodevelopment DOI
Sandra Zoubovsky, Louis J. Muglia

Neurotoxicology and Teratology, Год журнала: 2025, Номер 107, С. 107424 - 107424

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1

Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state DOI Creative Commons
Keita Watanabe, Mayu Yamano, Junki Miyamoto

и другие.

Cell Reports, Год журнала: 2025, Номер 44(3), С. 115433 - 115433

Опубликована: Март 1, 2025

Sex steroid hormones such as progesterone play a pivotal role in reproductive functions and maintaining pregnancy; however, the impact of on interaction between mother embryo is unclear. Here, we demonstrate that relationship maternal membrane receptor epsilon (mPRε) adipose tissue regulates embryonic nutritional environment growth after birth mice. The activation mPRε by increased during pregnancy enhances insulin resistance via prostaglandin production, efficiently providing glucose to embryos. Correspondingly, offspring mPRε-deficient mothers exhibited metabolic dysfunction, whereas with high-fat diet-induced obesity improved sensitivity. These findings establish importance regulator embryo. Additionally, may represent modulator for treating pregnant glycemic control disorders gestational diabetes mellitus, well syndrome offspring.

Язык: Английский

Процитировано

1

Effects of energy and amino acid intake during gestation on reproductive performance, milk composition, antioxidant status and placental nutrient transport in high-parity sows DOI Creative Commons
Liang Hu, Jie Zheng,

Fali Wu

и другие.

Frontiers in Veterinary Science, Год журнала: 2025, Номер 12

Опубликована: Апрель 28, 2025

Appropriate nutritional strategies show promise for enhancing productive performance and longevity of sows. This study aimed to determine the effects increased energy amino acids (AA) intake during gestation on reproductive performance, milk composition, blood parameters, placental nutrient transport antioxidant capacity high-parity A total 72 Landrace × Yorkshire sows (seventh ninth parity) were randomly assigned dietary treatments consisting combinations 2 levels AA in a factorial design. Blood samples placentas from collected measure biochemistry indexes, indicators related transport. The results showed that fed high reduced number live born piglets (p < 0.05), birth weight 0.05). Further observation decreased plasma progesterone at 30 60 days glutathione peroxidase (GPX) superoxide dismutase (T-SOD) 90 fat content colostrum average daily gain lactation Moreover, mRNA expression GPX glucose transporter 3 placenta High tendency increase litter protein 0.10), urea nitrogen day 110 T-SOD Furthermore, expressions extracellular SOD sodium-dependent neutral acid 1 In conclusion, feed negatively impacted fetal survival by reducing concentrations capacity, while simultaneously increasing piglet through enhanced received exhibited better redox status improved which can be attributed enhancements composition.

Язык: Английский

Процитировано

1

Regulation of placental amino acid transport in health and disease DOI
Hiroshi Shimada, Theresa L. Powell, Thomas Jansson

и другие.

Acta Physiologica, Год журнала: 2024, Номер 240(7)

Опубликована: Май 6, 2024

Abnormal fetal growth, i.e., intrauterine growth restriction (IUGR) or (FGR) and overgrowth, is associated with increased perinatal morbidity mortality strongly linked to the development of metabolic cardiovascular disease in childhood later life. Emerging evidence suggests that changes placental amino acid transport may contribute abnormal growth. This review focused on human placenta, however, relevant animal models will be discussed add mechanistic insights. At least 25 distinct transporters different characteristics substrate preferences have been identified placenta. Of these, System A, transporting neutral nonessential acids, L, mediating essential studied some detail. Importantly, decreased Systems A L transporter activity IUGR these two has overgrowth pregnancy. An array factors maternal circulation, including insulin, IGF-1, adiponectin, signaling pathways such as mTOR, key regulators L. Studies using trophoblast-specific gene targeting mice provided compelling are mechanistically altered It possible specific their upstream represents a novel intervention alleviate short- long-term consequences future.

Язык: Английский

Процитировано

3

The role of aryl hydrocarbon receptors in nutrient metabolism and immune regulation at the maternal–fetal interface DOI
Yuchen Li,

Xiaojun Yu,

Jing Shi

и другие.

Placenta, Год журнала: 2024, Номер 154, С. 9 - 17

Опубликована: Май 23, 2024

Язык: Английский

Процитировано

3

Towards understanding and halting legacies of trauma. DOI Creative Commons

W Taylor,

Laura Korobkova,

Nabeel Bhinderwala

и другие.

Biological Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

Effects of fermented wheat germ on the placenta of high-fat diet-induced obese maternal rats: morphology, metabolism, and nutrient transport DOI
Xiaolin Li, Yingyu Zhao, Jihong Huang

и другие.

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Fermented wheat germ improved morphology, alleviated metabolic disorders, and regulated nutrient transport of placenta in maternal rats with obesity induced by a high-fat diet.

Язык: Английский

Процитировано

0

Maternal immune activation elicits rapid and sex-dependent changes in gene expression and vascular dysfunction in the rat placenta DOI Creative Commons

Erin Biggar,

Ruth Thomas,

Megan L Lave

и другие.

Placenta, Год журнала: 2025, Номер 163, С. 51 - 60

Опубликована: Март 5, 2025

Язык: Английский

Процитировано

0

Methylation of the telomerase gene promoter region in umbilical cord blood of patients with gestational diabetes mellitus is associated with decreased telomerase expression levels and shortened telomere length DOI Creative Commons
Shuhua Liu,

Liping Xu,

Yan Cheng

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Март 11, 2025

Objective This study speculates that gestational diabetes mellitus (GDM) may reduce fetal telomere length (TL),which be related to modification of methylation in the promoter region telomerase (TE) gene region. Methods In this study, umbilical cord blood samples from patients with and without GDM (N = 100 each) were analyzed by prospective case-control. The TL, TE expression levels, levels TERT TERC regions two groups measured. significance level each CpG locus employed logistic regression analysis R software, covariance (ANCOVA) was used control influence confounding factors. Correlation performed Spearman. Results TL offspring decreased despite adjusting for PBMI, PWG, TG. A total islands screened three fragments (TERT_2, TERT_3, TERT_4) containing a 70 sites designed. Additionally, four group (TERT_2_40, TERT_2_47, TERT_3_46, TERT_3_212) showed increased compared (all P &lt; 0.05). gene, one island 19 loci designed, significantly different TERC_1_67 (0.65 ± 0.21 versus 0.57 0.30; 0.040) TERC_1_120 (0.68 0.23 0.59 0.27; 0.014). higher than those (0.69 0.06 0.65 0.08, 0.001). Conclusion revealed induce increasing genes region, thereby reducing TL.

Язык: Английский

Процитировано

0