bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июль 19, 2024
Summary Appendage shape is formed during development (and re-formed regeneration) according to spatial and temporal cues that orchestrate local cellular morphogenesis. The caudal fin the primary appendage used for propulsion in most fish species, exhibits a range of distinct morphologies adapted different swimming strategies, however molecular mechanisms responsible generating these diverse shapes remain mostly unknown. In zebrafish, fins display forked shape, with longer supportive bony rays at periphery shortest center. Here, we show premature, transient pulse sonic hedgehog (shha) overexpression late embryonic results excess proliferation growth central rays, causing adult grow into triangular, truncate shape. Both global regional ectopic shha are sufficient alter may be rescued by subsequent treatment an antagonist canonical Shh pathway. induced decreased ray number fail form hypural diastema normally separates dorsal ventral lobes. While regenerate their original morphology, truncate, suggesting positional memory can permanently altered embryogenesis. Ray finned have evolved wide spectrum morphologies, ranging from forked, current work offers insights developmental underlie this diversity.
Язык: Английский