Ubiquitous systems drift in the evolution of development

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Developmental systems drift (DSD) is a process where phenotypic trait conserved over evolutionary time, while the genetic basis for changes. DSD has been identified in models with simpler genotype-phenotype maps (GPMs), however extent of more complex GPMs, such as developmental systems, debated. To investigate occurrence we constructed multi-scale computational model evolution gene regulatory networks (GRNs) governing plant meristem (stem cell niche) development. We found that, during adaptation, some interactions became essential correct expression stem niche genes. These were subsequently thousands generations. Nevertheless, observed that these deeply could be lost extended period neutral evolution. losses compensated by changes elsewhere GRN, which then well. This gain and loss resulted continual cis -regulatory rewiring accumulated caused several Using two publicly available datasets confirmed prevalence across six divergent species, showed do not necessarily impact patterns, demonstrating DSD. findings align results from our model, showing pervasive systems. Statement significance A key open question evo-devo research evolvability phenotypes: to or beneficial change hindered deleterious mutations? investigated potential development using model. between genes changed extensively, resulting network underpinning Even replaced long time scales. genome data xsdatasets, high turnover cis-regulatory elements without consistent expression, confirming widespread predicted

Язык: Английский

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The application of irreversible genomic states to define and trace ancient cell type homologies

EvoDevo, Год журнала: 2025, Номер 16(1)

Опубликована: Май 3, 2025

Homology, or relationship among characters by common descent, has been notoriously difficult to assess for many morphological features, and cell types in particular. The ontogenetic origin of traits means that the only physically inherited information is encoded genomes. However, complexity underlying gene regulatory network often miniscule changes can impact expression, make it practically impossible postulate a clear demarcation line what molecular signature should "define" homologous type between two deeply branching animals. In this Hypothesis article, we propose use recently characterized irreversible genomic states, occur after chromosomal sub-chromosomal mixing genes elements, dissect signatures each into reversible configurations. While such states will be non-functional, some may permanently expression given type. Our proposal evolutionarily irreversible, thus synapomorphic, functional constitute criterion timing deep evolutionary homologies. aims close gap clearly defined homology individual their at phenotypic level through identification linked states.

Язык: Английский

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Units of Evolution (II): Higher Taxa and Homologues

Evolutionary Biology/Evolutionary biology, Год журнала: 2025, Номер unknown, С. 209 - 242

Опубликована: Янв. 1, 2025

Язык: Английский

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Promoting developmental diversity in a changing world

Development, Год журнала: 2024, Номер 151(20)

Опубликована: Окт. 15, 2024

Язык: Английский

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