Long-lived cytokinetic bridges coordinate sister-cell elimination in mouse embryos

Developmental Cell, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Activating the abscission checkpoint: Top2α senses chromatin bridges in cytokinesis

BioEssays, Год журнала: 2024, Номер 46(5)

Опубликована: Фев. 25, 2024

How chromatin bridges are detected by the abscission checkpoint during mammalian cell division is unknown. Here, we discuss recent findings from our lab showing that DNA topoisomerase IIα (Top2α) enzyme binds to catenated ("knotted") next midbody and forms abortive Top2-DNA cleavage complexes (Top2ccs) on bridges. Top2ccs then processed proteasome promote localization of damage sensor protein Rad17 Top2-generated double-strand ends knots. In turn, promotes local recruitment MRN complex downstream ATM-Chk2-INCENP signaling delay prevent bridge breakage in cytokinesis.

Язык: Английский

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Molecular and mechanical mechanisms of animal cell abscission

FEBS Letters, Год журнала: 2024, Номер unknown

Опубликована: Сен. 26, 2024

Cytokinesis leads to the distribution of segregated chromosomes, membrane, and cytoplasmic material in two daughter cells, ultimately concludes with abscission, their physical separation. In this Graphical Review, we outline key events that lead abscission discuss mechanisms delayed abscisison.

Язык: Английский

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Introducing our Associate Editorial Board: An interview with Agathe Chaigne, Utrecht University, The Netherlands

Cytoskeleton, Год журнала: 2024, Номер unknown

Опубликована: Сен. 28, 2024

Язык: Английский

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