Pathological Modulation of Genome Maintenance by Cancer/Testes Antigens (CTAs)

DNA repair, Год журнала: 2025, Номер 147, С. 103818 - 103818

Опубликована: Фев. 16, 2025

Язык: Английский

A nuclear TRiC/CCT chaperonin assembles meiotic HORMAD proteins into chromosome axes competent for crossing over

Опубликована: Март 3, 2025

Abstract The meiotic chromosome axis organizes chromatin and sets the stage for homolog pairing recombination. M eiotic HORMA d omain proteins (mHORMADs) are conserved components that conformationally transform during target binding. In C. elegans, four functionally distinct mHORMADs directly interact, but how binding between them is restricted to assembly unknown. Using a mutation in delays assembly, we isolated suppressor TRiC/CCT chaperonin subunit restored mHORMAD localization. CCT-4 associates with forms vivo complexes mHORMADs, while germline disruption of TRiC results defects, indicating nuclear function alongside chromosomes. We propose chromosome-tethered folds into active local population required morphogenesis. More broadly, our support model spatially-restricted folding by mechanism controlling multimeric tightly co-ordinated events.

Язык: Английский

Synaptonemal complex protects double-Holliday junctions during meiosis

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 15, 2024

Chromosomal linkages formed through crossover recombination are essential for accurate segregation of homologous chromosomes during meiosis

Язык: Английский