Control of odor sensation by light and cryptochrome in theDrosophilaantenna DOI Creative Commons
Dhananjay Thakur,

Sydney Hunt,

Tiffany Tsou

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Abstract Olfaction is a sense employed by insects to differentiate safe from harmful food options, evaluate potential mates, and identify oviposition sites. Here, we found that the fruit fly, Drosophila melanogaster , responds differently set of repulsive odors depending on ambient light conditions. Ultraviolet (UV) or blue reduces behavioral aversion electrophysiological responses olfactory receptor neurons (ORNs) certain repellent odors, such as benzaldehyde. We cryptochrome ( cry ) strongly expressed in antennal support cells lie adjacent ORNs, mutation eliminates light-dependent reduction aversion. Thus, these data demonstrate an organ serve sensory function cells. It has been shown activation Cry creates reactive oxygen species (ROS), ROS activates TRPA1 channel. TRPA1-C isoform required ORNs for benzaldehyde repulsion, activated vitro Overexpression dual oxygenase, which generates hydrogen peroxide, reduced under dark Our model creation peroxide persistently TRPA1-C. Consequently, channel no longer effectively Since flies sleep much more at night, begin feeding dawn, propose light-induced provides mechanism lower barrier following transition night day.

Язык: Английский

Control of odor sensation by light and cryptochrome in theDrosophilaantenna DOI Creative Commons
Dhananjay Thakur,

Sydney Hunt,

Tiffany Tsou

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Abstract Olfaction is a sense employed by insects to differentiate safe from harmful food options, evaluate potential mates, and identify oviposition sites. Here, we found that the fruit fly, Drosophila melanogaster , responds differently set of repulsive odors depending on ambient light conditions. Ultraviolet (UV) or blue reduces behavioral aversion electrophysiological responses olfactory receptor neurons (ORNs) certain repellent odors, such as benzaldehyde. We cryptochrome ( cry ) strongly expressed in antennal support cells lie adjacent ORNs, mutation eliminates light-dependent reduction aversion. Thus, these data demonstrate an organ serve sensory function cells. It has been shown activation Cry creates reactive oxygen species (ROS), ROS activates TRPA1 channel. TRPA1-C isoform required ORNs for benzaldehyde repulsion, activated vitro Overexpression dual oxygenase, which generates hydrogen peroxide, reduced under dark Our model creation peroxide persistently TRPA1-C. Consequently, channel no longer effectively Since flies sleep much more at night, begin feeding dawn, propose light-induced provides mechanism lower barrier following transition night day.

Язык: Английский

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