The Clinical Utility and Plausibility of Oxidative and Antioxidant Variables in Chronic and End-Stage Kidney Disease: A Review of the Literature
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3376 - 3376
Опубликована: Апрель 4, 2025
Oxidative
stress
(OS)
is
caused
by
an
imbalance
between
the
production
of
reactive
oxygen
species
(ROS)
in
cells
and
tissues
ability
biological
system
to
detoxify
these
products.
In
chronic
kidney
disease
(CKD),
OS
contributes
deterioration
function
progression.
patients
with
end-stage
undergoing
hemodialysis
or
peritoneal
dialysis,
further
increased
associated
adverse
clinical
outcomes,
including
subsequent
loss
residual
renal
function,
atherosclerosis,
hypertension,
cardiovascular
death.
However,
currently,
there
no
consensus
guidelines
for
diagnosis
treatment
patients.
Herein,
we
aim
present
existing
data
regarding
biomarkers
OS,
pro-oxidants
(oxidized
albumin,
advanced
oxidation
protein
products,
xanthine
oxidase/dehydrogenase,
nitrite/nitrate,
malondialdehyde)
antioxidants
(superoxide
dismutase,
catalase,
vitamin
E,
total
antioxidant
capacity,
N-acetylcysteine)
that
are
most
clinically
relevant
have
been
more
extensively
studied
disease,
aiming
provide
a
clearer
understanding
this
complex
area.
Язык: Английский
Ischemia-Modified Albumin (IMA) Is Associated with Poor Survival in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF): A Pilot Study
Antioxidants,
Год журнала:
2024,
Номер
13(3), С. 278 - 278
Опубликована: Фев. 25, 2024
There
are
increasing
efforts
to
better
predict
adverse
outcomes
for
idiopathic
pulmonary
fibrosis
(IPF).
Our
aim
was
assess
the
prognostic
potential
of
ischemia-modified
albumin
(IMA),
an
established
circulating
marker
ischemia
and,
more
recently,
oxidative
stress,
in
a
cohort
56
IPF
patients
recruited
between
2015
and
2023
at
University
Sassari,
Italy.
Demographic
functional
parameters
serum
IMA
concentrations
were
measured
baseline.
Non-survivors
had
significantly
higher
vs.
survivors
(508
±
64
474
42
mABSU,
respectively;
p
=
0.035).
The
Kaplan–Meier
analysis
showed
significant
association
values
poor
survival
(HR:
3.32,
95%
CI
from
1.06
10.4,
0.039).
In
Cox
regression
analysis,
this
remained
after
adjusting
force
expiratory
volume
1
s,
total
lung
capacity,
lymphocyte
count,
pharmacological
treatment
1.0154,
1.0035
1.0275,
0.01).
IMA,
stress
biomarker
measurable
using
relatively
simple
available
methods,
is
independently
associated
with
mortality
IPF.
Therefore,
its
determination
may
enhance
risk
stratification
decisions.
Prospective
studies
involving
larger
cohorts
needed
confirm
endorse
use
routine
practice.
Язык: Английский