Highlights From the European Respiratory Society Congress 2023: Chronic Obstructive Pulmonary Disease and Severe Asthma DOI Creative Commons
Eleanor Roberts

EMJ Respiratory, Год журнала: 2023, Номер unknown, С. 2 - 13

Опубликована: Ноя. 23, 2023

At the 2023 European Respiratory Society (ERS) International Congress, a significant part of scientific discussion revolved around asthma and chronic obstructive pulmonary disease (COPD), with multiple abstracts sessions dedicated to advances in targeted treatments, prevention, care plans for these patient groups. Clinical remission was one key topics severe (SA) sessions, focus on its definition, outcomes, perceptions. Additionally, biological their affected pathways, role helping patients achieve were central discussions. For COPD, much dialogue centred updated Global Initiative Chronic Obstructive Lung Disease (GOLD) guidelines, which classify according number exacerbations, dyspnoea, functional assessment, suggest personalised treatment. Such treatments numerous talks posters, as evidence is mounting use single inhaler triple therapy COPD ≥2 moderate exacerbations or ≥1 leading hospitalisation, positive impact symptoms quality life (QoL). Exacerbation prevention also notable topic, are more susceptible infections, often at higher risk complications, hospitalisations, death. Vaccination against vaccine-preventable diseases recommended cornerstone management respiratory patients, importance increasing awareness, access, uptake vaccines stressed.

Язык: Английский

Brazilian Thoracic Association recommendations for the management of post-tuberculosis lung disease DOI Creative Commons
Denise Rossato Silva, Ana Paula Santos, Dina Visca

и другие.

Jornal Brasileiro de Pneumologia, Год журнала: 2023, Номер unknown, С. e20230269 - e20230269

Опубликована: Ноя. 28, 2023

Historically, all efforts against tuberculosis were focused on rapid diagnosis and effective treatment to break the chain of transmission Mycobacterium tuberculosis. However, in last few years, more evidence has been found dramatic consequences condition defined as post-tuberculosis lung disease (PTLD). Approximately one third patients surviving pulmonary face considerable ongoing morbidities, including respiratory impairment, psychosocial challenges, reduced health-related quality life after completion. Given important global local burden tuberculosis, well estimated PTLD, development a consensus document by Brazilian scientific society-Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)-was considered urgent for prevention management this order allocate resources within services appropriately serve guide health care professionals. A team eleven pulmonologists methodologist was created SBPT review current PTLD develop recommendations adapted context. The expert panel selected topics basis international guidelines. During first phase, three members drafted recommendations, which divided into sections: definition prevalence assessment PTLD. In second reviewed, discussed, revised until reached. formally approved special session organized during 2023 Annual Conference.

Язык: Английский

Процитировано

12
Impact of seasonal biometeorological conditions and particulate matter on asthma and COPD hospital admissions DOI Creative Commons
Anna Romaszko–Wojtowicz, Ewa Dragańska, Anna Doboszyńska

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 2, 2025

Climate change and air pollution are pressing public health concerns, necessitating monitoring of their impact, particularly on respiratory diseases like obstructive lung diseases. This retrospective study analyzed medical records patients hospitalized at the Warmia Mazury Centre for Pulmonary Diseases in Olsztyn, Poland (2012–2021) asthma chronic pulmonary disease (COPD) exacerbations. Data included meteorological factors such as temperature, humidity, wind speed, precipitation, levels PM2.5 PM10. The Humidex was utilized to assess thermal discomfort, considering various seasons. Findings indicated seasonal variability COPD During winter, poorer quality due higher PM10 correlated with increased exacerbations (r = 0.283, p < 0.05; r 0.491, 0.001). In summer, discomfort from conditions led more hospital admissions. values strongly admissions (R2 0.956 asthma; R2 0.659 COPD), July August showing statistically admission rates (p 0.05). highlights significant impact COPD, serving a valuable predictor during summer months.

Язык: Английский

Процитировано

0
Gene Expression Profiles Reveal Distinct Mechanisms Driving Chronic Obstructive Pulmonary Disease Exacerbations DOI Open Access
Melissa Belló-Pérez, Eduardo García-Pachón, Nieves Gonzalo-Jiménez

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 627 - 627

Опубликована: Янв. 13, 2025

Chronic obstructive pulmonary disease (COPD) exacerbations are major contributors to morbidity and mortality, highlighting the need better understand their molecular mechanisms improve prevention, diagnosis, treatment. This study investigated differential gene expression profiles key biological processes in COPD categorized based on sputum microbiome profiling. An observational was performed a cohort of 16 patients, who provided blood samples during exacerbations, along with five stable-state as controls. Exacerbations were classified using 16S rRNA sequencing analyze microbiota multiplex PCR detect respiratory viruses. Blood transcriptomic profiling conducted Oxford Nanopore technology, followed by pathway enrichment analyses. A total 768 regulated genes identified across exacerbation groups, 35 shared associated neutrophil activation. Bacterial activated pathways related phagocytosis toll-like receptor signaling, while viral linked pro-inflammatory responses mitochondrial damage. unknown origin showed activation involved protozoan defense neutrophilic asthma. Biomarkers such IFITM3 ISG15 for bacterial DEFA3 viral, CD47 unknown-origin identified. These findings highlight distinct emphasizing central role neutrophil-driven inflammation identifying potential biomarkers improved diagnosis personalized management.

Язык: Английский

Процитировано

0
ASK1 inhibition by selonsertib attenuates elastase-induced emphysema in mice DOI

Priscilla Cristine de Oliveira Mineiro,

Vanderlei da Silva Fraga‐Junior, Aline de Oliveira Pontes Cardoso

и другие.

Life Sciences, Год журнала: 2025, Номер unknown, С. 123600 - 123600

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
COPD risk due to extreme temperature exposure: combining epidemiological evidence with pathophysiological mechanisms DOI Creative Commons

Jiayu Xu,

Guogang Xu,

Zehua Liu

и другие.

EBioMedicine, Год журнала: 2025, Номер 116, С. 105731 - 105731

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Editorial: Climate Change and the Spread of Vector-Borne Diseases, Including Dengue, Malaria, Lyme Disease, and West Nile Virus Infection DOI Creative Commons

Dinah V. Parums

Medical Science Monitor, Год журнала: 2023, Номер 29

Опубликована: Дек. 20, 2023

The major health threats from climate change include increasing temperatures, air pollution, extreme weather events, changes in the spread of infectious diseases, antimicrobial resistance, emerging pathogens, and an increase vector-borne disease.Between October December 2023, 200 medical journal, epidemiologists, clinicians, healthcare policymakers, journal editors published emergency call to action professionals, United Nations, political leaders on its effects ecosystem human health.Also, Intergovernmental Panel Climate Change (IPCC) sixth Assessment Report (AR6) that summarizes current knowledge, impacts, risks change, as well suggestions for mitigation adaptation.For over a decade, IPCC has reported prevalence diseases increased highlighted importance monitoring dengue, malaria, Lyme disease, West Nile virus infection, other diseases.This editorial aims provide update association between highlights urgent need public disease prevention treatment strategies control rise diseases.

Язык: Английский

Процитировано

6
Path analysis of illness perception, medication beliefs, family support on adherence to inhalants in elderly COPD patients: based on triadic reciprocal determinism DOI

You-Ran Liu,

Yan Wang,

Jingjing Liu

и другие.

Patient Education and Counseling, Год журнала: 2024, Номер 130, С. 108465 - 108465

Опубликована: Окт. 11, 2024

Язык: Английский

Процитировано

0
BENEFÍCIOS DO TREINAMENTO MUSCULAR INSPIRATÓRIO NA REABILITAÇÃO PULMONAR EM PACIENTES COM DOENÇA PULMONAR OBSTRUTIVA CRÔNICA DOI Creative Commons

Kênia Jaine da Silva Monteiro,

Késya Ellen do Nascimento,

Artur Silva

и другие.

Revista Contemporânea, Год журнала: 2024, Номер 4(11), С. e6512 - e6512

Опубликована: Ноя. 11, 2024

A Doença Obstrutiva Crônica Pulmonar (DPOC) é a terceira principal causa de morte no mundo, considerada uma patologia respiratória progressiva comum desencadeada por agentes, dentre eles o tabagismo e exposição substâncias tóxicas. O paciente com DPOC apresenta diminuição da força resistência muscular durante inspiração, levando-o à menor tolerância ao esforço afetando sua capacidade realizar AVDs (Atividades Vida Diárias). Dessa forma, torna-se importante prática fisioterapia realização reabilitação pulmonar Treinamento Muscular Inspiratório (TMI), que vem sendo extremamente promissor na DPOC. Portanto, esta pesquisa objetiva identificar os benefícios do em pacientes meio revisão integrativa literatura, concentrou as buscas nas bases dados Cochrane; Ebsco Open Research; Medline; Pubmed Scielo. Foram incluídos apenas ensaios clínicos publicados nos últimos 5 anos idiomas inglês português. Dos 2170 estudos encontrados 8 estavam acordo objetivo presente neles foi possível diversidade dos programas tratamento relação carga aplicada dispositivos treinamento combinação outras intervenções envolvendo TMI. Diante disso, identificou TMI promove aumento musculatura respiratória, redução dispneia DPOC, também potencializados quando associados intervenções.

Процитировано

0
Highlights From the European Respiratory Society Congress 2023: Chronic Obstructive Pulmonary Disease and Severe Asthma DOI Creative Commons
Eleanor Roberts

EMJ Respiratory, Год журнала: 2023, Номер unknown, С. 2 - 13

Опубликована: Ноя. 23, 2023

At the 2023 European Respiratory Society (ERS) International Congress, a significant part of scientific discussion revolved around asthma and chronic obstructive pulmonary disease (COPD), with multiple abstracts sessions dedicated to advances in targeted treatments, prevention, care plans for these patient groups. Clinical remission was one key topics severe (SA) sessions, focus on its definition, outcomes, perceptions. Additionally, biological their affected pathways, role helping patients achieve were central discussions. For COPD, much dialogue centred updated Global Initiative Chronic Obstructive Lung Disease (GOLD) guidelines, which classify according number exacerbations, dyspnoea, functional assessment, suggest personalised treatment. Such treatments numerous talks posters, as evidence is mounting use single inhaler triple therapy COPD ≥2 moderate exacerbations or ≥1 leading hospitalisation, positive impact symptoms quality life (QoL). Exacerbation prevention also notable topic, are more susceptible infections, often at higher risk complications, hospitalisations, death. Vaccination against vaccine-preventable diseases recommended cornerstone management respiratory patients, importance increasing awareness, access, uptake vaccines stressed.

Язык: Английский

Процитировано

0