The Contentious Origins of SARS-CoV-2: A Comprehensive Review of Current Knowledge
Опубликована: Фев. 11, 2025
The
emergence
of
SARS-CoV-2
in
late
2019
triggered
a
global
pandemic
(COVID-19)
that
has
claimed
millions
lives
and
continues
to
impact
public
health
systems
worldwide.
This
review
examines
current
scientific
evidence
regarding
the
virus's
origins,
focusing
on
two
primary
hypotheses:
zoonotic
spillover
laboratory-related
emergence.
A
comprehensive
analysis
peer-reviewed
literature
published
between
December
2023
January
2025
was
conducted,
identifying
relevant
studies
through
searches
PubMed
Scopus
databases.
revealed
strong
phylogenetic
supporting
natural
origin,
with
several
indicating
close
genetic
relationships
bat
coronaviruses.
Environmental
sampling
data
from
Huanan
Seafood
Market
detected
RNA
high
number
environmental
samples
animal
stalls.
While
preponderance
supports
spillover,
absence
definitively
identified
intermediate
host
maintains
some
uncertainty.
concludes
evidence-based
recommendations
for
enhanced
viral
surveillance,
implementation
One
Health
approaches,
strengthened
international
collaboration
frameworks
prevent
future
coronavirus
pandemics.
Язык: Английский
The Contentious Origins of SARS-CoV-2: A Comprehensive Review of Current Knowledge
Опубликована: Фев. 17, 2025
The
emergence
of
SARS-CoV-2
in
late
2019
triggered
a
global
pandemic
(COVID-19)
that
has
claimed
millions
lives
and
continues
to
impact
public
health
systems
worldwide.
This
review
examines
current
scientific
evidence
regarding
the
virus's
origins,
focusing
on
two
primary
hypotheses:
zoonotic
spillover
laboratory-related
emergence.
A
comprehensive
analysis
peer-reviewed
literature
primarily
published
between
December
2023
January
2025
was
conducted,
identifying
relevant
studies
through
searches
PubMed
Scopus
databases.
Key
earlier
publications
are
also
included
provide
essential
background
context.
revealed
strong
phylogenetic
supporting
natural
origin,
with
several
indicating
close
genetic
relationships
bat
coronaviruses.
Environmental
sampling
data
from
Huanan
Seafood
Market
detected
RNA
high
number
environmental
samples
animal
stalls.
While
preponderance
supports
spillover,
absence
definitively
identified
intermediate
host
maintains
some
uncertainty.
concludes
evidence-based
recommendations
for
enhanced
viral
surveillance,
implementation
One
Health
approaches,
strengthened
international
collaboration
frameworks
prevent
future
coronavirus
pandemics.
Язык: Английский
The Contentious Origins of SARS-CoV-2: A Comprehensive Review of Current Knowledge
Опубликована: Фев. 19, 2025
The
emergence
of
SARS-CoV-2
in
late
2019
triggered
a
global
pandemic
(COVID-19)
that
has
claimed
millions
lives
and
continues
to
impact
public
health
systems
worldwide.
This
review
examines
current
scientific
evidence
regarding
the
virus's
origins,
focusing
on
two
primary
hypotheses:
zoonotic
spillover
laboratory-related
emergence.
A
comprehensive
analysis
peer-reviewed
literature
primarily
published
between
December
2023
January
2025
was
conducted,
identifying
relevant
studies
through
searches
PubMed
Scopus
databases.
Key
earlier
publications
are
also
included
provide
essential
background
context.
revealed
strong
phylogenetic
supporting
natural
origin,
with
several
indicating
close
genetic
relationships
bat
coronaviruses.
Environmental
sampling
data
from
Huanan
Seafood
Market
detected
RNA
high
number
environmental
samples
animal
stalls.
While
preponderance
supports
spillover,
absence
definitively
identified
intermediate
host
maintains
some
uncertainty.
concludes
evidence-based
recommendations
for
enhanced
viral
surveillance,
implementation
One
Health
approaches,
strengthened
international
collaboration
frameworks
prevent
future
coronavirus
pandemics.
Язык: Английский
Long COVID: General Perceptions and Challenges in Diagnosis and Management
Katia Ozanic,
Aripuanã Sakurada Aranha Watanabe,
Andre Machado
и другие.
COVID,
Год журнала:
2025,
Номер
5(3), С. 41 - 41
Опубликована: Март 12, 2025
On
11
March
2020,
the
World
Health
Organization
(WHO)
declared
a
pandemic
caused
by
SARS-CoV-2,
raising
global
health
concerns.
Reports
of
persistent
and
new
symptoms
following
acute
phase
infection
highlighted
complexities
recovery
prompted
investigation
what
is
now
termed
long
COVID.
Officially
recognized
WHO
in
October
2021,
COVID
presents
various
implications,
though
terminology—such
as
post-COVID
syndrome
post-acute
sequelae
COVID-19
(PASC)—remains
inconsistent,
complicating
diagnostic
standardization.
Long
affects
an
estimated
10%
to
30%
SARS-CoV-2-infected
individuals,
with
common
including
fatigue,
dyspnea,
cognitive
dysfunction,
joint
pain,
all
which
significantly
impair
quality
life.
Public
perception
influenced
factors
like
education
history,
while
misinformation
stigma
hinder
accurate
diagnosis
treatment.
The
absence
biomarkers
overlap
other
post-viral
syndromes
further
complicate
clinical
recognition.
Experts
emphasize
need
for
refined
criteria
integrated
strategies
combining
biomedical
research,
public
policy,
educational
initiatives
improve
management,
address
healthcare
inequalities,
mitigate
impacts
This
review
unveils
state
art
knowledge
gaps
encourage
discussion,
aim
achieving
better
decision-making
awareness
related
Язык: Английский
Lights and Shadows of Long COVID: Are Latent Infections the Real Hidden Enemy?
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(23), С. 7124 - 7124
Опубликована: Ноя. 25, 2024
Long
COVID-19
(LC)
is
a
poorly
understood,
multifactorial
condition
that
persists
for
at
least
three
months
following
SARS-CoV-2
infection.
The
underlying
pathophysiological
mechanisms
responsible
the
wide
range
of
associated
symptoms-including
fatigue,
brain
fog,
and
respiratory
issues-remain
unclear.
However,
emerging
evidence
suggests
reactivation
latent
viral
infections,
such
as
Epstein-Barr
virus,
cytomegalovirus,
varicella-zoster
may
significantly
contribute
to
complexity
LC.
These
viruses
can
be
reactivated
by
SARS-CoV-2,
contributing
chronic
inflammatory
state
prolongs
symptomatology.
This
review
confirms
potential
involvement
infections
in
LC
examines
whether
these
play
an
independent
role
or
act
synergistically
with
other
factors.
In
addition,
recent
studies
have
highlighted
persistence
immune
dysregulation
key
elements
Our
findings
suggest
preventative
strategies,
including
vaccination
antiviral
treatments
during
acute
phase
COVID-19,
show
reducing
risk
preventing
reactivation.
tailored
diagnostic
therapeutic
strategies
targeting
are
urgently
needed.
Identifying
biomarkers
reactivation,
particularly
high-risk
populations,
could
considered
another
effective
strategy
mitigate
severity.
Further
research
crucial
better
understand
interactions
between
improve
prevention
treatment
Язык: Английский