Hydrogen Sulfide Modulation of Matrix Metalloproteinases and CD147/EMMPRIN: Mechanistic Pathways and Impact on Atherosclerosis Progression
Biomedicines,
Год журнала:
2024,
Номер
12(9), С. 1951 - 1951
Опубликована: Авг. 26, 2024
Atherosclerosis
is
a
chronic
inflammatory
condition
marked
by
endothelial
dysfunction,
lipid
accumulation,
cell
infiltration,
and
extracellular
matrix
(ECM)
remodeling
within
arterial
walls,
leading
to
plaque
formation
potential
cardiovascular
events.
Key
players
in
ECM
inflammation
are
metalloproteinases
(MMPs)
CD147/EMMPRIN,
surface
glycoprotein
expressed
on
cells,
vascular
smooth
muscle
cells
(VSMCs),
immune
that
regulates
MMP
activity.
Hydrogen
sulfide
(H₂S),
gaseous
signaling
molecule,
has
emerged
as
significant
modulator
of
these
processes
including
oxidative
stress
mitigation,
reduction,
remodeling.
This
systematic
review
investigates
the
mechanistic
pathways
through
which
H₂S
influences
MMPs
CD147/EMMPRIN
assesses
its
impact
atherosclerosis
progression.
A
comprehensive
literature
search
was
conducted
across
PubMed,
Scopus,
Web
Science
databases,
focusing
studies
examining
modulation
contexts.
Findings
indicate
modulates
expression
activity
transcriptional
regulation
post-translational
modifications,
S-sulfhydration.
By
mitigating
stress,
reduces
activation,
contributing
stability
also
downregulates
via
pathways,
diminishing
responses
cellular
proliferation
plaques.
The
dual
regulatory
role
inhibiting
downregulating
CD147
suggests
therapeutic
agent
stabilizing
atherosclerotic
plaques
inflammation.
Further
research
warranted
elucidate
precise
molecular
mechanisms
explore
H₂S-based
therapies
for
clinical
application
atherosclerosis.
Язык: Английский
Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1062 - 1062
Опубликована: Авг. 30, 2024
Neurodegenerative
diseases
encompass
a
spectrum
of
disorders
marked
by
the
progressive
degeneration
structure
and
function
nervous
system.
These
conditions,
including
Parkinson's
disease
(PD),
Alzheimer's
(AD),
Huntington's
(HD),
Amyotrophic
lateral
sclerosis
(ALS),
Multiple
(MS),
often
lead
to
severe
cognitive
motor
deficits.
A
critical
component
neurodegenerative
pathologies
is
imbalance
between
pro-oxidant
antioxidant
mechanisms,
culminating
in
oxidative
stress.
The
brain's
high
oxygen
consumption
lipid-rich
environment
make
it
particularly
vulnerable
damage.
Pro-oxidants
such
as
reactive
nitrogen
species
(RNS)
(ROS)
are
continuously
generated
during
normal
metabolism,
counteracted
enzymatic
non-enzymatic
defenses.
In
diseases,
this
balance
disrupted,
leading
neuronal
This
systematic
review
explores
roles
stress,
gut
microbiota,
epigenetic
modifications
aiming
elucidate
interplay
these
factors
identify
potential
therapeutic
strategies.
We
conducted
comprehensive
search
articles
published
2024
across
major
databases,
focusing
on
studies
examining
relationships
redox
homeostasis,
changes
neurodegeneration.
total
161
were
included,
comprising
clinical
trials,
observational
studies,
experimental
research.
Our
findings
reveal
that
stress
plays
central
role
pathogenesis
with
microbiota
composition
significantly
influencing
balance.
Specific
bacterial
taxa
markers
identified
modulators
suggesting
novel
avenues
for
intervention.
Moreover,
recent
evidence
from
human
animal
supports
emerging
concept
targeting
homeostasis
through
therapies.
Future
research
should
focus
validating
targets
settings
exploring
personalized
medicine
strategies
based
individual
profiles.
Язык: Английский
Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 344 - 344
Опубликована: Фев. 27, 2025
Age-related
oxidative
stress
is
a
critical
factor
in
vascular
dysfunction,
contributing
to
hypertension
and
atherosclerosis.
Smooth
muscle
cells
endothelial
are
particularly
susceptible
damage,
which
exacerbates
aging
through
cellular
senescence,
chronic
inflammation,
arterial
stiffness.
Gasotransmitters—hydrogen
sulfide
(H2S),
nitric
oxide
(NO),
carbon
monoxide
(CO)—are
emerging
as
promising
therapeutic
agents
for
counteracting
these
processes.
This
review
synthesizes
findings
from
recent
studies
focusing
on
the
mechanisms
by
H2S,
NO,
CO
influence
smooth
cell
function.
Therapeutic
strategies
involving
exogenous
gasotransmitter
delivery
systems
combination
therapies
were
analyzed.
H2S
enhances
mitochondrial
bioenergetics,
scavenges
ROS,
activates
antioxidant
pathways.
NO
improves
function,
promotes
vasodilation,
inhibits
platelet
aggregation.
exhibits
cytoprotective
anti-inflammatory
effects
modulating
heme
oxygenase
activity
ROS
production.
In
preclinical
studies,
gasotransmitter-releasing
molecules
(e.g.,
NaHS,
SNAP,
CORMs)
targeted
show
significant
promise.
Synergistic
with
lifestyle
modifications
further
enhance
their
potential.
conclusion,
gasotransmitters
hold
promise
combat
age-related
cells.
Their
multifaceted
innovative
approaches
make
them
potential
candidates
treating
dysfunction
promoting
healthy
aging.
Further
research
needed
translate
into
clinical
applications.
Язык: Английский
Perineal Rehabilitation in Pelvic Floor Dysfunction: The Benefits of Vaginal Cone Training
Balneo and PRM Research Journal,
Год журнала:
2024,
Номер
15(Vol.15, no. 3), С. 729 - 729
Опубликована: Сен. 25, 2024
Pelvic
floor
dysfunctions
(PFD)
are
prevalent
conditions
that
affect
millions
of
women
worldwide,
encompassing
a
range
issues
severely
affecting
women's
quality
life.
muscle
strength
and
function
fundamental
to
the
management
prevention
PFD,
pelvic
rehabilitation
is
non-invasive
approach
effectively
improves
symptoms,
restores
function,
prevents
complications.
This
study
aimed
evaluate
impact
training
program
using
weighted
vaginal
cones,
on
life
in
with
dysfunction
(PFD).
Fifty-four
aged
26-62
years,
different
type
urinary
incontinence,
cystocele,
prolapse
participated
this
pre-post
intervention
comparative
analysis.
was
assessed
PC
test,
which
measures
strength,
endurance
fatigability,
while
patients'
Floor
Impact
Questionnaire
-
Short
Form
7
(PFIQ-7).
A
three-month
cone
regimen
implemented,
as-sessments
conducted
before
(T0),
one
month
later
(T1),
three
months
(T2).
Data
analysis
showed
change
significant
differences
between
test
score
values
at
level
each
parameter
assessment
(p<0.05,
ES=0.254-511).
The
scores
for
bladder
problems
Urinary
(UIQ-7)
significantly
de-creased
from
38.901
±
1.268
T0
29.366
2.493
T2
(W
=
1082.000,
p
<
0.001,
ES=0.570).
In
contrast,
or
(POPIQ-7)
slight,
insignificant
decrease
12.699
1.128
10.499
2.362
278.000,
0.800,
ES=0.053).
fVaginal
mus-cle
reduces
urynary
symptoms
PFD.
Язык: Английский
Biomechanical Prānāyāma Breathing Involves the Anti- Inflammatory Reflex of the Vagus Nerve in Survival Imputation
Biomedical Journal of Scientific & Technical Research,
Год журнала:
2023,
Номер
53(5)
Опубликована: Ноя. 14, 2023
The
metabolism
and
homeostasis
of
living
in
thermodynamic
laws
is
governed
by
both
intrinsic
extrinsic
innate
adaptive
immunity
a
temporospatial
state.Neuronal
reflexes
that
originate
from
tissue
hypoxia
inflammasome
are
casual
mass
action
kinetics
for
accelerated
structural
failure.Functionally
the
reflex
like
Alfvén
waves
structure-function
interpolant
bio
signal
workflow.The
physical
layers
regulate
response
include
HPA
axis,
Vagus
Nerve,
reticuloendothelial
melanocortin
systems.The
metabolic
function
Gibbs'
free
energy
supply
chain
to
prevent
imbalances
as
feedback
errors
arcs
with
Endotheliopathy
induction.Vagus
Nerve
stimulation
efficacy
anti-inflammatory
treatment,
currently
framework
frequency
emission
devices
regulatory
approved
Europe
United
States
epilepsy,
cardiac
disorder
acute
respiratory
distress.On
other
hand,
ancient
pattern
Prānāyāma
has
attributes
parasympathetic
expression
objectification.The
neuro-arch
effect,
which
involves
skeletal
muscle
laryngeal
frequency-emitting
wavelets,
suggests
every
exercise
leads
immune-mediated
challenges.The
'Yoga-medical
'
was
created
S-VYASA
University,
collaboration
Western
culture,
provide
homecare
distress
related
treatment.In
Italy,
small
ancillary
sample
size
tested
three
time
day
cycles
survival
endpoint
SARS-COV-2
outbreak
during
February
May
2020
pandemic
period.The
dataset
belongs
protocol-compliant
subgroup
(trial
identifier
NCT04413747)
first
second
stage
virus
infection.The
Bayesian
borrowing
ranked
sensitivity
analysis
accordance
ICH
E9
(R1)
stochastic
demographic
geolocation.The
Weibull-k
factor
inference
resulted
probability
distribution
2.5
ratio
<
15%
chance.The
relative
risk
death
daily
rate
reduced
19-fod
significance
level
point
estimate
p
=
0.02
two-side
CI
97.5
%.
Язык: Английский
Biomechanical Prānāyāma Breathing Involves the Anti- Inflammatory Reflex of the Vagus Nerve in Survival Imputation
American Journal of Biomedical Science & Research,
Год журнала:
2023,
Номер
20(1), С. 76 - 79
Опубликована: Сен. 11, 2023
The
metabolism
and
homeostasis
of
living
in
thermodynamic
laws
is
governed
by
both
intrinsic
extrinsic
innate
adaptive
immunity
a
temporospatial
state.
Neuronal
reflexes
that
originate
from
tissue
hypoxia
inflammasome
are
casual
mass
action
kinetics
for
accelerated
structural
failure.
Functionally
the
reflex
like
Alfvén
waves
structure-function
interpolant
biosignal
workflow.
physical
layers
regulate
response
include
HPA
axis,
Vagus
Nerve,
reticuloendothelial
melanocortin
systems.
metabolic
function
Gibbs'
free
energy
supply
chain
to
prevent
imbalances
as
feedback
errors
arcs
with
endotheliopathy
induction.
Nerve
stimulation
efficacy
anti-inflammatory
treatment,
currently
framework
frequency
emission
devices
regulatory
approved
Europe
United
States
epilepsy,
cardiac
disorder
acute
respiratory
distress.
On
other
hand,
ancient
pattern
Prānāyāma
has
attributes
parasympathetic
expression
objectification.
neuro-arch
effect,
which
involves
skeletal
muscle
laryngeal
frequencyemitting
wavelets,
suggests
every
exercise
leads
immune-mediated
challenges.
'Yoga-medical
was
created
S-VYASA
University,
collaboration
Western
culture,
provide
homecare
distress
related
treatment.
In
Italy,
small
ancillary
sample
size
tested
three
time
day
cycles
survival
endpoint
SARS-COV-2
outbreak
during
February
May
2020
pandemic
period.
dataset
belongs
protocol-compliant
subgroup
(trial
identifier
NCT04413747)
first
second
stage
virus
infection.
Bayesian
borrowing
were
ranked
sensitivity
analysis
accordance
ICH
E9
(R1)
stochastic
demographic
geolocation.
Weibull-k
factor
inference
resulted
probability
distribution
2.5
ratio
<15%
chance.
relative
risk
death
daily
rate
reduced
19-fod
significance
level
point
estimate
p=0.02
two-side
CI
97.5
%.
Язык: Английский