International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1772 - 1772
Опубликована: Фев. 19, 2025
Ribosome
biogenesis
is
one
of
the
most
fundamental
and
energetically
demanding
cellular
processes.
In
humans,
ribosomal
DNA
(rDNA)
repeats
span
a
large
region
comprise
200
to
600
copies
~43
kb
unit
spread
over
five
different
chromosomes.
Control
ribosome
closely
tied
regulation
chromatin
environment
this
genomic
region.
The
proportion
rDNA
loci
which
are
active
or
silent
altered
depending
on
proliferative
metabolic
state
cell.
Repeat
silencing
driven
by
epigenetic
changes
culminating
in
repressive
heterochromatin
environment.
One
group
proteins
facilitating
these
response
growth
demands
ATP-dependent
remodeling
protein
complexes
that
use
ATP
hydrolysis
reposition
nucleosomes.
Indeed,
some
remodelers
known
have
indispensable
roles
regulating
rDNA.
review,
we
highlight
their
describe
mechanistic
at
We
also
introduce
developmental
disorders
arising
from
dysfunction
discuss
how
consequent
dysregulation
may
be
reflected
phenotypes
observed.
Biology,
Год журнала:
2025,
Номер
14(1), С. 92 - 92
Опубликована: Янв. 18, 2025
This
proposed
review
aims
to
shed
light
on
the
major
genetic
and
epigenetic
contributions
ageing
process
longevity
of
individuals.
In
this
context,
we
summarize
state
knowledge
most
important
variants,
their
interactions
with
environment,
in
achieving
a
healthy
lifespan.
We
also
explore
contribution
lifestyle
influence
non-heritable
environmental
factors
(i.e.,
epigenetics).
Accordingly,
discuss
role
inflammageing
as
one
targets
overcome
morbidity
mortality
older
people
for
maintenance
ageing.
more
integrated
view
will
display
not
only
underlying
mechanisms
at
play
but
invites
reader
rethink
both
our
attitudes
toward
age.
Proceedings of the National Academy of Sciences,
Год журнала:
2025,
Номер
122(5)
Опубликована: Янв. 30, 2025
Aging
is
a
complex
process
that
affects
multiple
organs,
and
the
discovery
of
pharmacological
approach
to
ameliorate
aging
considered
Holy
Grail
medicine.
Here,
we
performed
an
N-ethyl-N-nitrosourea
forward
genetic
screening
in
zebrafish
identified
accelerated
mutant
named
meteor
(
met
),
harboring
mutation
Werner
syndrome
RecQ
-
like
helicase
wrn
)
gene.
Loss
leads
short
lifespan
age-related
characteristics
intestine
embryos,
such
as
cellular
senescence,
genomic
instability,
epigenetic
alteration.
Therefore,
conducted
antiaging
drugs
using
revealed
sapanisertib
effectively
ameliorated
most
phenotypes
mutant.
Mechanistically,
geroprotective
effects
may
be
attributed
inhibition
mTORC1/2.
Furthermore,
also
attenuated
chronological
wild-type
aged
replicative-senescence
human
foreskin
fibroblasts.
Taken
together,
our
study
introduces
unique
efficient
model
for
large-scale
drug
vertebrates
suggests
potential
therapeutic
option
treating
premature
promoting
healthy
aging.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1772 - 1772
Опубликована: Фев. 19, 2025
Ribosome
biogenesis
is
one
of
the
most
fundamental
and
energetically
demanding
cellular
processes.
In
humans,
ribosomal
DNA
(rDNA)
repeats
span
a
large
region
comprise
200
to
600
copies
~43
kb
unit
spread
over
five
different
chromosomes.
Control
ribosome
closely
tied
regulation
chromatin
environment
this
genomic
region.
The
proportion
rDNA
loci
which
are
active
or
silent
altered
depending
on
proliferative
metabolic
state
cell.
Repeat
silencing
driven
by
epigenetic
changes
culminating
in
repressive
heterochromatin
environment.
One
group
proteins
facilitating
these
response
growth
demands
ATP-dependent
remodeling
protein
complexes
that
use
ATP
hydrolysis
reposition
nucleosomes.
Indeed,
some
remodelers
known
have
indispensable
roles
regulating
rDNA.
review,
we
highlight
their
describe
mechanistic
at
We
also
introduce
developmental
disorders
arising
from
dysfunction
discuss
how
consequent
dysregulation
may
be
reflected
phenotypes
observed.
