The therapeutic potential of exercise in post-traumatic stress disorder and its underlying mechanisms: A living systematic review of human and non-human studies DOI Creative Commons
Simonne Wright, Virginia Chiocchia, Olufisayo Elugbadebo

и другие.

Wellcome Open Research, Год журнала: 2025, Номер 9, С. 720 - 720

Опубликована: Апрель 7, 2025

Background Exercise for post-traumatic stress disorder (PTSD) is a potentially effective adjunct to psychotherapy. However, the biopsychosocial mechanisms of exercise are not well understood. This co-produced living systematic review synthesizes evidence from human and non-human studies. Methods We Included controlled studies involving searches multiple electronic databases (until 31.10.23). Records were screened, extracted, assessed risk bias, reconciled by two independent reviewers. The primary outcome was PTSD symptom severity, while outcomes interest included freezing behaviour, fear memory, generalization, startle response, locomotion. Data synthesised with random-effects meta-analysis. Results Eleven met eligibility criteria. Overall, associated severity improvement compared control (standardized mean difference [SMD] -0.08, 95% confidence interval [CI] -0.24 0.07; 8 studies, one at low bias). High-intensity reduced symptoms scores more than moderate-intensity exercise. There insufficient data examine effects on functional impairment, clusters, remission. Only three all high examined inconclusive results. in behavioural outcomes, including locomotor activity (SMD 1.30, CI 0.74 1.87, 14 studies), changes several neurobiological markers, increase brain-derived neurotrophic factor 1.79, 0.56 3.01). Conclusions While provide compelling beneficial exercise, trials do not. Evidence suggest that might levels factor, enhance cognitive appraisal, improve perceived exertion. paucity effectiveness action underscore need rigorous trials. Registration protocol registered PROSPERO (ID:453615; 22.08.2023).

Язык: Английский

The therapeutic potential of exercise in post-traumatic stress disorder and its underlying mechanisms: A living systematic review of human and non-human studies DOI Creative Commons
Simonne Wright, Virginia Chiocchia, Olufisayo Elugbadebo

и другие.

Wellcome Open Research, Год журнала: 2025, Номер 9, С. 720 - 720

Опубликована: Апрель 7, 2025

Background Exercise for post-traumatic stress disorder (PTSD) is a potentially effective adjunct to psychotherapy. However, the biopsychosocial mechanisms of exercise are not well understood. This co-produced living systematic review synthesizes evidence from human and non-human studies. Methods We Included controlled studies involving searches multiple electronic databases (until 31.10.23). Records were screened, extracted, assessed risk bias, reconciled by two independent reviewers. The primary outcome was PTSD symptom severity, while outcomes interest included freezing behaviour, fear memory, generalization, startle response, locomotion. Data synthesised with random-effects meta-analysis. Results Eleven met eligibility criteria. Overall, associated severity improvement compared control (standardized mean difference [SMD] -0.08, 95% confidence interval [CI] -0.24 0.07; 8 studies, one at low bias). High-intensity reduced symptoms scores more than moderate-intensity exercise. There insufficient data examine effects on functional impairment, clusters, remission. Only three all high examined inconclusive results. in behavioural outcomes, including locomotor activity (SMD 1.30, CI 0.74 1.87, 14 studies), changes several neurobiological markers, increase brain-derived neurotrophic factor 1.79, 0.56 3.01). Conclusions While provide compelling beneficial exercise, trials do not. Evidence suggest that might levels factor, enhance cognitive appraisal, improve perceived exertion. paucity effectiveness action underscore need rigorous trials. Registration protocol registered PROSPERO (ID:453615; 22.08.2023).

Язык: Английский

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