Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Год журнала: 2016, Номер 809, С. 24 - 32
Опубликована: Сен. 9, 2016
Язык: Английский
ACS Nano, Год журнала: 2016, Номер 10(4), С. 4511 - 4519
Опубликована: Март 27, 2016
Ionizing radiation (gamma and x-ray) is widely used in industry medicine, but it can also pose a significant hazardous effect on health induce cancer, physical deformity even death, due to DNA damages invasion of free radicals. There therefore an urgent unmet demand designing highly efficient radioprotectants with synergetic integration effective renal clearance low toxicity. In this study, we designed ultrasmall (sub-5 nm) catalytically active cysteine-protected MoS2 dots as investigated their application protection against ionizing radiation. vivo preclinical studies showed that the surviving fraction MoS2-treated mice appreciably increase up 79 % when they were exposed high-energy Furthermore, contribute cleaning accumulated radicals within body, repairing recovering all vital chemical biochemical indicators, suggesting unique role radical scavengers. rapid urinary excretion more than 80 injected dose (I.D.) eliminated from body after 24 hours hydrodynamic size did not cause any noticeable toxic responses 30 days.
Язык: Английский
Процитировано
121
PLoS ONE, Год журнала: 2017, Номер 12(4), С. e0174474 - e0174474
Опубликована: Апрель 12, 2017
Radiotherapy-induced gut toxicity is among the most prevalent dose-limiting toxicities following radiotherapy. Prevention of radiation enteropathy requires protection small intestine. However, despite prevalence and burden this pathology, there are currently no effective treatments for radiotherapy-induced toxicity, pathology remains unclear. The present study aimed to investigate changes induced in rat intestine after external irradiation tongue, explore potential radio-protective effects melatonin gel. Male Wistar rats were subjected their tongues with an X-Ray YXLON Y.Tu 320-D03 irradiator, receiving a dose 7.5 Gy/day 5 days. For 21 days post-irradiation, treated 45 mg/day gel or vehicle, by local application into mouths. Our results showed that mitochondrial oxidative stress, bioenergetic impairment, subsequent NLRP3 inflammasome activation involved development toxicity. Oral treatment had protective effect intestine, which was associated and, consequently, reduced inflammatory response, blunting NF-κB/NLRP3 signaling activation. Thus, intestinal apoptosis, relieving mucosal dysfunction facilitating mucosa recovery. findings suggest oral may be preventive therapy cancer patients.
Язык: Английский
Процитировано
109
International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(16), С. 5804 - 5804
Опубликована: Авг. 13, 2020
Ionizing radiation (IR) has found widespread application in modern medicine, including medical imaging and radiotherapy. As a result, both patients healthcare professionals are exposed to various IR doses. To minimize the negative side effects of associated with oxidative imbalance, antioxidant therapy been considered. In this review, studies on melatonin vitamin D radiation-induced stress discussed. According research data, substances meet conditions for use as agents that protect humans against IR-induced tissue damage. Numerous have confirmed melatonin, hydro- lipophilic hormone strong properties, can potentially be used radioprotectant humans. Less is known about radioprotective D, but results date promising. Deficiencies common societies may contribute severity adverse exposure. Hence, supporting supplementation seems first importance. Interestingly, selectively radiosensitise cancer cells, which makes them promising adjuvants More needed area, especially
Язык: Английский
Процитировано
106
Biophysical Reviews, Год журнала: 2017, Номер 9(2), С. 139 - 148
Опубликована: Март 27, 2017
Язык: Английский
Процитировано
94
Mutation Research/Reviews in Mutation Research, Год журнала: 2016, Номер 770, С. 219 - 230
Опубликована: Авг. 15, 2016
Язык: Английский
Процитировано
91
Drug Discovery Today, Год журнала: 2018, Номер 23(4), С. 763 - 770
Опубликована: Янв. 6, 2018
Язык: Английский
Процитировано
89
BMC Medicine, Год журнала: 2018, Номер 16(1)
Опубликована: Фев. 1, 2018
Our aims were to evaluate critically the evidence from systematic reviews as well narrative of effects melatonin (MLT) on health and identify potential mechanisms action involved. An umbrella review across endogenous exogenous (supplementation) MLT was undertaken. The Oxman checklist for assessing methodological quality included utilised. following databases searched: MEDLINE, EMBASE, Web Science, CENTRAL, PsycINFO CINAHL. In addition, reference lists screened. We any type health-related outcome measure. Altogether, 195 met inclusion criteria. Most low (mean -4.5, standard deviation 6.7). Of those, 164 did not pool data synthesised narratively (qualitatively) whereas remaining 31 used meta-analytic techniques quantitatively. Seven meta-analyses significant with P values less than 0.001 under random-effects model. These pertained sleep latency, pre-operative anxiety, prevention agitation risk breast cancer. There is an abundance evaluating health. general, has been shown be associated a wide variety outcomes in clinically methodologically heterogeneous populations. Many stressed need more high-quality randomised clinical trials reduce existing uncertainties.
Язык: Английский
Процитировано
88
Expert Opinion on Investigational Drugs, Год журнала: 2012, Номер 21(6), С. 819 - 831
Опубликована: Апрель 16, 2012
Introduction: The possible oncostatic properties of melatonin on different types neoplasias have been studied especially in hormone-dependent adenocarcinomas. Despite the promising results these experimental investigations, use breast cancer treatment humans is still uncommon.
Язык: Английский
Процитировано
104
Therapeutic Advances in Endocrinology and Metabolism, Год журнала: 2013, Номер 4(1), С. 13 - 24
Опубликована: Фев. 1, 2013
Melatonin is a methoxyindole synthesized within the pineal gland. The hormone secreted during night and appears to play multiple roles human organism. contributes regulation of biological rhythms, may induce sleep, has strong antioxidant action contribute protection organism from carcinogenesis neurodegenerative disorders. At therapeutic level as well in prevention, melatonin used for management sleep disorders jet lag, resynchronization circadian rhythms situations such blindness shift work, its preventive development cancer, additive therapy cancer preventing progression Alzheimer's disease other
Язык: Английский
Процитировано
101
Free Radical Research, Год журнала: 2010, Номер 44(3), С. 275 - 282
Опубликована: Янв. 1, 2010
It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. Since most of the ionizing radiation-induced cellular damage is caused by radicals, this study was designed to test hypothesis may be an effective radioprotective agent. This paper demonstrates treating cells with before irradiation could significantly inhibit irradiation(IR)-induced Human Lymphocyte AHH-1 apoptosis increase viability also shows protect gastrointestinal endothelia from injury, decrease plasma malondialdehyde (MDA) intestinal 8-hydroxydeoxyguanosine (8-OHDG) levels endogenous antioxidants vivo. suggested a potential as safe
Язык: Английский
Процитировано
99