Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation

Journal of Radiation Research, Год журнала: 2012, Номер 54(3), С. 494 - 514

Опубликована: Дек. 23, 2012

For tumor therapy with light ions and for experimental aspects in particle radiobiology the relative biological effectiveness (RBE) is an important quantity to describe increased of radiation.By establishing analysing a database ion photon cell survival data, some remarkable properties RBE-related quantities were observed.The consists 855 vitro experiments after irradiation.The comprise curves obtained different labs, using species, irradiation modalities, whole range accessible energies linear energy transfers (LETs) various types.Each curve has been parameterized linear-quadratic (LQ) model.The parameters, α β, appear be slightly anti-correlated, which might point toward underlying mechanism.The RBE values derived from support known dependence on LET, species dose.A positive correlation ratio α/β LQ parameters found at low doses, unexpectedly changes negative high doses.Furthermore, we investigated course β coefficient model increasing finding typically slight initial increase final falloff zero.The observed fluctuations comparable resemble overall uncertainties, relevance treatment planning.The can also used extensive testing models.We thus compare simulations local effect achieve this goal.

Язык: Английский

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Classification of radiation effects for dose limitation purposes: history, current situation and future prospects

Journal of Radiation Research, Год журнала: 2014, Номер 55(4), С. 629 - 640

Опубликована: Май 3, 2014

Radiation exposure causes cancer and non-cancer health effects, each of which differs greatly in the shape dose–response curve, latency, persistency, recurrence, curability, fatality impact on quality life. In recent decades, for dose limitation purposes, International Commission Radiological Protection has divided such diverse effects into tissue reactions (formerly termed non-stochastic deterministic effects) stochastic effects. On one hand, effective limits aim to reduce risks (cancer/heritable are based detriment-adjusted nominal risk coefficients, assuming a linear-non-threshold response rate effectiveness factor 2. other equivalent avoid (vision-impairing cataracts cosmetically unacceptable skin changes) threshold dose. However, boundary between these two categories is becoming vague. Thus, we review changes radiation effect classification, concepts, definition detriment threshold. Then, current situation overviewed focusing (i) with threshold, (ii) without (iii) target organs/tissues circulatory disease, (iv) levels vs prevention non-life-threatening life-threatening reactions, (v) mortality or incidence thyroid cancer, (vi) reactions. For future discussion, approach suggested that classifies according whether life threatening, radiobiological research needs also briefly discussed.

Язык: Английский

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Inverse dose protraction effects of low-LET radiation: evidence and significance

Mutation Research/Reviews in Mutation Research, Год журнала: 2025, Номер unknown, С. 108531 - 108531

Опубликована: Янв. 1, 2025

Язык: Английский

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Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

Cancers, Год журнала: 2017, Номер 9(6), С. 66 - 66

Опубликована: Июнь 9, 2017

Compared to conventional photon-based external beam radiation (PhXRT), carbon ion radiotherapy (CIRT) has superior dose distribution, higher linear energy transfer (LET), and a relative biological effectiveness (RBE). This enhanced RBE is driven by unique DNA damage signature characterized clustered lesions that overwhelm the repair capacity of malignant cells. These physical radiobiological characteristics imbue heavy ions with potent tumoricidal capacity, while having potential for simultaneously maximally sparing normal tissues. Thus, CIRT could potentially be used treat some most difficult tumors, including those are hypoxic, radio-resistant, or deep-seated. Clinical data, mostly from Japan Germany, promising, favorable oncologic outcomes acceptable toxicity. In this manuscript, we review rationales CIRT, an emphasis on repair, as well providing comprehensive overview translational clinical data using CIRT.

Язык: Английский

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Carbon Ion Radiotherapy: Clinical Experiences at National Institute of Radiological Science (NIRS)

Journal of Radiation Research, Год журнала: 2010, Номер 51(4), С. 355 - 364

Опубликована: Янв. 1, 2010

In June 1994, the world's first clinical center offering carbon ion radiotherapy opened at National Institute of Radiological Science (NIRS), Japan. Among several types species, ions were chosen for cancer therapy because they judged to have most optimal properties in terms superior physical and biological characteristics. As March 2010, 5,196 patients been registered radiotherapy. Clinical results shown that has potential provide a sufficient radiation dose tumor, while having acceptable morbidity surrounding normal tissues. Tumors appear respond favorably include locally advanced tumors as well histologically non-squamous cell tumor such adenocarcinoma, adenoid cystic carcinoma, malignant melanoma, hepatoma, bone/soft tissue sarcoma. By taking advantage unique ions, treatment with small fractions within short period successfully carried out variety tumors. This means can offer larger numbers than is possible other modalities over same time period.

Язык: Английский

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Particle radiotherapy with carbon ion beams

The EPMA Journal, Год журнала: 2013, Номер 4(1)

Опубликована: Март 4, 2013

Carbon ion radiotherapy offers superior dose conformity in the treatment of deep-seated malignant tumours compared with conventional X-ray therapy. In addition, carbon beams have a higher relative biological effectiveness protons or beams. The algorithm planning and beam delivery system is tailored to individual parameters patient. present article reviews available literatures for various disease sites including head neck, skull base, lung, liver, prostate, bone soft tissues pelvic recurrence rectal cancer as well physical properties.

Язык: Английский

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Ionizing radiation induced cataracts: Recent biological and mechanistic developments and perspectives for future research

Mutation Research/Reviews in Mutation Research, Год журнала: 2016, Номер 770, С. 238 - 261

Опубликована: Июль 31, 2016

Язык: Английский

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Repair of DNA damage induced by accelerated heavy ions—A mini review

International Journal of Cancer, Год журнала: 2011, Номер 130(5), С. 991 - 1000

Опубликована: Сен. 20, 2011

Increasing use of heavy ions for cancer therapy and concerns from exposure to charged particles in space necessitate the study basic biological mechanisms associated with ions. As most critical damage induced by ionizing radiation is DNA double strand break (DSB), this review focuses on DSBs their repair processes. Compared X- or gamma-rays, high-linear energy transfer (LET) ion induces more complex damage, categorized into non-DSB oxidative clustered lesions (OCDL). This complexity makes process difficult, partially due retarded enzymatic activities, leading increased chromosome aberrations cell death. In general, following LET-dependent, but nonhomologous end joining defective cells, trend less emphasized. The variation survival levels throughout cycle prominent cells exposed high-LET when compared low LET, mechanism has not been well understood until recently. Involvement several DSB proteins suggested underlie interesting phenomenon. Recent improvements radiation-induced foci studies combined could provide a useful opportunity depth Accelerated have become valuable tools investigate molecular underlying DSBs, crucial form various chemotherapeutic agents.

Язык: Английский

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Real-Time Time-Dependent Density Functional Theory for Simulating Nonequilibrium Electron Dynamics

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(8), С. 5011 - 5029

Опубликована: Фев. 16, 2024

The explicit real-time propagation approach for time-dependent density functional theory (RT-TDDFT) has increasingly become a popular first-principles computational method modeling various electronic properties of complex chemical systems. In this Perspective, we provide nontechnical discussion how simulation been used to gain novel physical insights into nonequilibrium electron dynamics phenomena in recent years. Following concise overview the RT-TDDFT methodology from practical standpoint, discuss our studies on stopping DNA water and Floquet topological phase as examples. Our focuses simulations played unique role deriving new scientific understandings. We then existing challenges some advances at frontier development studying dynamic

Язык: Английский

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Inverse dose protraction effects of high-LET radiation: evidence and significance

Mutation Research/Reviews in Mutation Research, Год журнала: 2025, Номер unknown, С. 108530 - 108530

Опубликована: Янв. 1, 2025

Язык: Английский

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