Advancements in Utilizing Natural Compounds for Modulating Autophagy in Liver Cancer: Molecular Mechanisms and Therapeutic Targets DOI Creative Commons
Md. Ataur Rahman, S M Rakib-Uz-Zaman, Somdeepa Chakraborti

и другие.

Cells, Год журнала: 2024, Номер 13(14), С. 1186 - 1186

Опубликована: Июль 12, 2024

Autophagy, an intrinsic catabolic mechanism that eliminates misfolded proteins, dysfunctional organelles, and lipid droplets, plays a vital function in energy balance cytoplasmic quality control, addition to maintaining cellular homeostasis. Liver cancer such as hepatocellular carcinoma (HCC) is one of the most common causes deaths globally shows resistance several anticancer drugs. Despite rising incidence poor prognosis malignant HCC, underlying molecular mechanisms driving this aggressive remain unclear. Several natural compounds, phytochemicals dietary non-dietary origin, affect hepatocarcinogenesis signaling pathways vitro vivo, which may help prevent treat HCC cells. Current cells treatments include chemotherapy, radiation, surgery. However, these standard therapies have substantial side effects, combination therapy enhances effects for acceptable therapeutic benefit. Therefore, there need develop treatment strategies are more efficacious fewer adverse effects. Multiple genetic epigenetic factors responsible become resistant treatment. Autophagy contributes maintain homeostasis, activates autophagy biosynthesis mitochondrial regulation recycling. modifying autophagic would present promising opportunity identify novel current treatments. This comprehensive review illustrates how compounds demonstrate their anti-hepatocellular through autophagy.

Язык: Английский

Advancements in Utilizing Natural Compounds for Modulating Autophagy in Liver Cancer: Molecular Mechanisms and Therapeutic Targets DOI Creative Commons
Md. Ataur Rahman, S M Rakib-Uz-Zaman, Somdeepa Chakraborti

и другие.

Cells, Год журнала: 2024, Номер 13(14), С. 1186 - 1186

Опубликована: Июль 12, 2024

Autophagy, an intrinsic catabolic mechanism that eliminates misfolded proteins, dysfunctional organelles, and lipid droplets, plays a vital function in energy balance cytoplasmic quality control, addition to maintaining cellular homeostasis. Liver cancer such as hepatocellular carcinoma (HCC) is one of the most common causes deaths globally shows resistance several anticancer drugs. Despite rising incidence poor prognosis malignant HCC, underlying molecular mechanisms driving this aggressive remain unclear. Several natural compounds, phytochemicals dietary non-dietary origin, affect hepatocarcinogenesis signaling pathways vitro vivo, which may help prevent treat HCC cells. Current cells treatments include chemotherapy, radiation, surgery. However, these standard therapies have substantial side effects, combination therapy enhances effects for acceptable therapeutic benefit. Therefore, there need develop treatment strategies are more efficacious fewer adverse effects. Multiple genetic epigenetic factors responsible become resistant treatment. Autophagy contributes maintain homeostasis, activates autophagy biosynthesis mitochondrial regulation recycling. modifying autophagic would present promising opportunity identify novel current treatments. This comprehensive review illustrates how compounds demonstrate their anti-hepatocellular through autophagy.

Язык: Английский

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