medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 7, 2023
Abstract
Background
Poststroke
rehabilitation
reportedly
improves
functional
outcomes
and
minimizes
disability.
However,
previous
studies
have
demonstrated
conflicting
results
regarding
the
effects
of
therapy
on
post-stroke
mortality.
Therefore,
we
aimed
to
investigate
association
between
within
first
six
months
after
stroke
long-term
all-cause
mortality
in
patients
with
using
data
from
Korean
National
Health
Insurance
System.
Methods
A
total
10,974
newly
diagnosed
ICD-10
codes
(I60-I64)
2013
2019
were
enrolled
followed-up
for
until
2019.
Post-stroke
categorized
into
three
groups
according
frequency
therapy:
no
therapy,
≤
40
sessions,
>
sessions.
Cox
proportional
hazard
models
used
assess
risk
stratified
by
disability
severity.
Results
Higher
was
associated
significantly
lower
comparison
(HR=0.88,
95%
CI
0.79-0.9
9),
especially
among
individuals
severe
(HR=0.74,
0.62-0.87).
An
inverse
number
sessions
identified
a
multivariate
regression
model
restricted
cubic
splines.
In
context
type,
higher
reduced
rates
compared
only
hemorrhagic
(HR=0.60,
0.49-0.74).
While
socioeconomic
factors
not
mortality,
older
age,
male
sex,
pneumonia
increased
risk,
regardless
Conclusions
onset
seems
play
substantial
role
reducing
stroke.
is
recommended
patients,
particularly
those
Gels,
Год журнала:
2025,
Номер
11(4), С. 260 - 260
Опубликована: Апрель 1, 2025
Stroke
remains
a
leading
cause
of
disability
worldwide,
underscoring
the
urgent
need
for
novel
and
innovative
therapeutic
strategies
to
enhance
neuroprotection,
support
regeneration,
improve
functional
recovery.
Previous
research
has
shown
that
phytochemicals
such
as
curcumin,
tannic
acid,
gallic
ginsenosides,
resveratrol,
isorhamnetin
display
extensive
neuroprotective
properties,
including
antioxidant,
anti-inflammatory,
anti-apoptotic
effects.
These
natural
compounds
could
also
promote
neurogenesis,
angiogenesis,
preservation
blood–brain
barrier.
Despite
their
promising
bioactivities,
clinical
application
is
often
limited
by
poor
solubility,
bioavailability,
suboptimal
pharmacokinetics.
Hydrogels
offer
solution
encapsulating
controlling
gradual
release
these
directly
at
site
injury.
Recent
advancements
in
hydrogel
formulations,
constructed
from
biopolymers
functionalized
using
nanotechnological
approaches,
significantly
stability,
targeted
delivery
phytochemicals.
Controlled
profiles
pH-sensitive
environment-responsive
hydrogels
ensure
compounds’
effects
are
optimally
timed
with
individual
critical
stages
post-stroke
repair.
Moreover,
scaffolds
tailored
material
properties
biocompatibility
can
create
favorable
microenvironment,
reducing
secondary
inflammation,
enhancing
tissue
potentially
improving
cognitive
outcomes
following
stroke.
This
review
explores
potential
integrating
within
hydrogel-based
systems
specifically
designed
The
design
synthesis
biocompatible,
biodegradable
especially
applications
discussed.
Lastly,
we
emphasize
additional
robust
translatable
preclinical
studies.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(5), С. 1358 - 1358
Опубликована: Фев. 27, 2024
Stroke
stands
as
a
significant
global
health
concern,
constituting
leading
cause
of
disability
worldwide.
Rehabilitation
interventions
are
crucial
in
aiding
the
recovery
stroke
patients,
contributing
to
an
overall
enhancement
their
quality
life.
This
scoping
review
seeks
identify
current
trends
gait
rehabilitation
for
survivors.
Gels,
Год журнала:
2024,
Номер
10(7), С. 476 - 476
Опубликована: Июль 18, 2024
Stroke
remains
the
second
leading
cause
of
death
and
a
major
disability
worldwide,
significantly
impacting
individuals,
families,
healthcare
systems.
This
neurological
emergency
can
be
triggered
by
ischemic
events,
including
small
vessel
arteriolosclerosis,
cardioembolism,
large
artery
atherothromboembolism,
as
well
hemorrhagic
incidents
resulting
from
macrovascular
lesions,
venous
sinus
thrombosis,
or
vascular
malformations,
to
significant
neuronal
damage.
The
resultant
motor
impairment,
cognitive
dysfunction,
emotional
disturbances
underscore
urgent
need
for
effective
therapeutic
interventions.
Recent
advancements
in
biomaterials,
particularly
hydrogels,
offer
promising
new
avenues
stroke
management.
Hydrogels,
composed
three-dimensional
networks
hydrophilic
polymers,
are
notable
their
ability
absorb
retain
substantial
amounts
water.
Commonly
used
polymers
hydrogel
formulations
include
natural
like
alginate,
chitosan,
collagen,
synthetic
such
polyethylene
glycol
(PEG),
polyvinyl
alcohol
(PVA),
polyacrylamide.
Their
customizable
characteristics—such
porosity,
swelling
behavior,
mechanical
strength,
degradation
rates—make
hydrogels
ideal
biomedical
applications,
drug
delivery,
cell
tissue
engineering,
controlled
release
agents.
review
comprehensively
explores
hydrogel-based
approaches
both
therapy,
elucidating
mechanisms
which
provide
neuroprotection.
It
covers
application
delivery
systems,
role
reducing
inflammation
secondary
injury,
potential
support
neurogenesis
angiogenesis.
also
discusses
current
technology
challenges
translating
these
innovations
research
into
clinical
practice.
Additionally,
it
emphasizes
limited
number
trials
utilizing
therapies
addresses
associated
limitations
constraints,
underscoring
further
this
field.
Life,
Год журнала:
2024,
Номер
14(9), С. 1110 - 1110
Опубликована: Сен. 3, 2024
Post-stroke
depression
(PSD)
represents
a
significant
neuropsychiatric
complication
that
affects
between
39%
and
52%
of
stroke
survivors,
leading
to
impaired
recovery,
decreased
quality
life,
increased
mortality.
This
comprehensive
review
synthesizes
our
current
knowledge
PSD,
encompassing
its
epidemiology,
risk
factors,
underlying
neurochemical
mechanisms,
the
existing
tools
for
preclinical
investigation,
including
animal
models
behavioral
analyses.
Despite
high
prevalence
severe
impact
challenges
persist
in
accurately
modeling
complex
symptomatology
settings,
underscoring
need
robust
valid
better
understand
treat
PSD.
also
highlights
multidimensional
nature
where
both
biological
psychosocial
factors
interplay
influence
onset
course.
Further,
we
examine
efficacy
limitations
mimicking
human
PSD
condition,
along
with
tests
used
evaluate
depressive-like
behaviors
rodents.
sets
new
precedent
by
integrating
latest
findings
across
multidisciplinary
studies,
thereby
offering
unique
perspective
knowledge.
Finally,
development
more
sophisticated
closely
replicate
clinical
features
is
crucial
order
advance
translational
research
facilitate
discovery
future
effective
therapies.
International Journal of Environmental Research and Public Health,
Год журнала:
2023,
Номер
20(19), С. 6829 - 6829
Опубликована: Сен. 26, 2023
Balance
impairment
is
a
common
consequence
of
stroke,
which
can
significantly
hinder
individuals’
participation
in
daily
activities,
social
interactions,
and
leisure
pursuits
their
ability
to
return
work.
Rehabilitation
vital
for
minimizing
post-stroke
sequelae
facilitating
the
recovery
patients.
This
review
aims
identify
current
trends
balance
rehabilitation
stroke
survivors.
Scoping
followed
Arksey
O’Malley’s
methodological
framework.
The
literature
search
was
conducted
electronic
databases,
including
CINAHL
Complete,
MEDLINE
Nursing
&
Allied
Health
Collection.
performed
March
2023,
inclusion
criteria
were
articles
published
English
or
Portuguese
between
2013
2023.
A
total
446
identified.
After
selecting
analyzing
reports,
fourteen
publications
included
this
review.
Seven
distinct
categories
interventions
identified,
covering
various
approaches.
These
conventional
exercises,
gym-based
interventions,
vibration
therapy,
rhythmic
auditory
stimulation
training,
boxing
dual-task
technology-based
interventions.
Each
these
methods
presents
unique
benefits
impact
survivors,
enhancing
overall
well-being
functional
capacity.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 11, 2024
Abstract
Injuries
affecting
the
central
nervous
system
may
disrupt
neural
pathways
to
muscles
causing
motor
deficits.
Yet
brain
exhibits
sensorimotor
rhythms
(SMRs)
during
movement
intents,
and
brain-computer
interfaces
(BCIs)
can
decode
SMRs
control
assistive
devices
promote
functional
recovery.
However,
non-invasive
BCIs
suffer
from
instability
of
SMRs,
requiring
longitudinal
training
for
users
learn
proper
SMR
modulation.
Here,
we
accelerate
this
skill
learning
process
by
applying
cervical
transcutaneous
electrical
spinal
stimulation
(TESS)
inhibit
cortex
prior
upper-limb
BCI
training.
Results
support
a
mechanistic
role
cortical
inhibition
in
significantly
increasing
focality
strength
leading
accelerated
healthy
subjects
an
individual
with
cord
injury.
Improvements
were
observed
following
only
two
TESS
sessions
maintained
at
least
one
week
who
could
not
otherwise
achieve
control.
Our
findings
provide
promising
possibilities
advancing
BCI-based
rehabilitation.
Laboratory Animal Research,
Год журнала:
2025,
Номер
41(1)
Опубликована: Янв. 2, 2025
Abstract
Ischemic
stroke
(IS)
is
the
most
recorded
case
of
that
caused
by
decreased
blood
flow
to
brain.
Nowadays,
therapeutical
agents
for
IS
are
limited
and
they
have
not
shown
maximum
clinical
results.
Therefore,
exploration
new
candidates
treatment
continues
be
done.
Zebrafish
as
one
animal
models
has
its
advantages
currently
being
developed
incorporated
into
drug
discovery
pipeline
IS.
This
review
explores
latest
applications
zebrafish
model
in
screening
potential
therapeutic
Key
factors
related
experimental
design
such
developmental
stage
strain,
routes
administration,
induction
methods,
parameters
also
elaborated.
Finally,
this
offers
future
recommendations
use
pre-clinical
study
beneficial
a
reference
establishing
protocols
using
model.
Medicina,
Год журнала:
2025,
Номер
61(4), С. 627 - 627
Опубликована: Март 29, 2025
Background
and
Objectives:
Stroke
is
a
leading
cause
of
disability
worldwide.
Recent
studies
have
suggested
the
feasibility
potential
utility
remotely
supervised
transcranial
direct
current
stimulation
(RS-tDCS)
to
improve
different
types
impairments
in
various
neurological
conditions.
This
scoping
review
provides
critical
appraisal
RS-tDCS
as
an
adjunct
therapy
enhance
recovery
after
stroke.
Materials
Methods:
A
comprehensive
literature
was
systematically
conducted
using
PubMed
through
Nested
Knowledge
software.
supplementary
search
Google
Scholar.
Two
independent
authors
screened
identified
related
investigating
patients
with
stroke
from
inception
February
2025.
Results:
Studies
showed
that
safe,
only
mild
side
effects.
Additionally,
it
feasible,
high
adherence
rates
likely
due
ease
use.
Regarding
efficacy,
preliminarily
yielded
improvements
upper-
lower-limb
motor
functions
increased
language
cognitive
performance.
However,
were
underpowered
heterogeneous,
limiting
generalization
findings.
Conclusions:
safe
affording
beneficial
effects
motor,
language,
post-stroke
impairments.
has
access
reduce
disparities
for
experimental
treatments.
adequately
powered
randomized
trials
are
needed
further
investigate
efficacy.
