Emerging Therapies for Neurological Disorders: A Clinical Review of MANAGED (Music, Art, Nature-Based, Animal-Assisted, Game, Essential Oil, Dance) Care

NeuroSci, Год журнала: 2025, Номер 6(2), С. 51 - 51

Опубликована: Июнь 4, 2025

In the face of limitations in pharmacological and surgical interventions for neurological conditions such as Parkinson’s Alzheimer’s disease, patients are increasingly turning to non-pharmacological alternative therapies manage their symptoms improve quality life. This shift underscores urgent need accessible, effective, affordable treatments. literature review examines a range personalized therapies, including game therapy, animal-assisted dance art music aroma shinrin-yoku therapy. These modalities have demonstrated promising results mitigating enhancing well-being among individuals grappling with disorders. Moreover, these offer holistic approach that complements traditional medical interventions, underscoring importance integrating diverse treatment modalities. Despite historical roots non-clinical settings, potential modern clinical practice remains untapped. The findings suggest necessity further research, particularly large cohort studies, validate efficacy advocate widespread adoption. an era marked by escalating healthcare costs, exploration presents compelling avenue patient care while simultaneously addressing economic challenges within system.

Язык: Английский

---

Transcutaneous Electrical Spinal Cord Stimulation Promotes Focal Sensorimotor Activation that Accelerates Brain-Computer Interface Skill Learning

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 11, 2024

Abstract Injuries affecting the central nervous system may disrupt neural pathways to muscles causing motor deficits. Yet brain exhibits sensorimotor rhythms (SMRs) during movement intents, and brain-computer interfaces (BCIs) can decode SMRs control assistive devices promote functional recovery. However, non-invasive BCIs suffer from instability of SMRs, requiring longitudinal training for users learn proper SMR modulation. Here, we accelerate this skill learning process by applying cervical transcutaneous electrical spinal stimulation (TESS) inhibit cortex prior upper-limb BCI training. Results support a mechanistic role cortical inhibition in significantly increasing focality strength leading accelerated healthy subjects an individual with cord injury. Improvements were observed following only two TESS sessions maintained at least one week who could not otherwise achieve control. Our findings provide promising possibilities advancing BCI-based rehabilitation.

Язык: Английский

---

MRI-Based Personalized Transcranial Direct Current Stimulation to Enhance the Upper Limb Function in Patients with Stroke: Study Protocol for a Double-Blind Randomized Controlled Trial

Brain Sciences, Год журнала: 2022, Номер 12(12), С. 1673 - 1673

Опубликована: Дек. 5, 2022

Transcranial direct current stimulation (tDCS) has been shown to have the potential improve motor recovery of affected upper limbs in patients with stroke, and recently, several optimized tDCS methods proposed magnify its effectiveness. This study aims determine effectiveness personalized using brain MRI-based electrical field simulation optimization, enhance patients. trial is a double-blind, randomized controlled subacute chronic rehabilitation phase. Forty-two adult stroke unilateral limb involvement will be randomly allocated three groups: (1) stimulation, (2) conventional bihemispheric primary cortex, (3) sham tDCS. All groups undergo 10 intervention sessions 30 min 2-mA intensity during regular program over two weeks. The outcome measure for impairment Fugl-Meyer assessment extremity score at end intervention, secondary measures include changes evoked potentials, frequency power coherence electroencephalography, performance activities daily living, adverse events 1-month follow-up assessment. analyzed on intention-to-treat principle. There paucity studies regarding that considers individual lesions characteristics real world. No feasibility or pivotal performed MRI, lesion-specific optimization obstacles segmentation analysis tissue, such as ischemic hemorrhagic lesions. contribute addressing safety tDCS, stroke.

Язык: Английский

---

Association Between Frequency of Rehabilitation Therapy and Long-Term Mortality After Stroke: A Nationwide Cohort Study

Stroke, Год журнала: 2024, Номер 55(9), С. 2274 - 2283

Опубликована: Авг. 5, 2024

Previous studies have demonstrated conflicting results regarding the effects of rehabilitation therapy on poststroke mortality. We aimed to investigate association between therapy, including both inpatient and outpatient treatment, within first 6 months after stroke long-term all-cause mortality in patients with using Korean National Health Insurance System data.

Язык: Английский

---

Predictors of upper limb motor recovery in stroke survivors: a pre–post test study design

BMJ Open, Год журнала: 2024, Номер 14(11), С. e081936 - e081936

Опубликована: Ноя. 1, 2024

Objectives The study aimed to assess the predictors of upper limb motor recovery in stroke survivors. Design Pre–post test design. Setting Conducted two centres (First Level Hospital and University Teaching Lusaka). Participants Patients living with accessing physiotherapy services at public hospitals. A total 52 patients were recruited start study, 6 lost follow-up 46 completed study. Intervention Conventional for 8 weeks (5 September 2022–28 October 2022). Primary outcome Motor function measured using a Fugl-Meyer assessment extremity. Results Analysis was conducted on participants. significant difference observed between level baseline after treatment (p=0.0183). At baseline, 50% participants had mild function, which improved weeks, 69.6% having function. Stroke severe impairment associated 0.01 times likelihood (AOR 0.01; 95 % CI 0.00 0.16; p=0.002). Conclusion continues improve over time. This demonstrated that initial could be used as predictor

Язык: Английский

---

Remote Ischemic Conditioning for Motor Recovery after Acute Ischemic Stroke

The Neurologist, Год журнала: 2023, Номер 28(6), С. 367 - 372

Опубликована: Май 24, 2023

Background: Remote ischemic conditioning (RIC) has shown an impressive neuroprotective effect on acute stroke (AIS) in animal experiments. But whether chronic RIC improves long-term functional outcomes remains unclear. Materials and Methods: We performed a non-randomized controlled trial. Eligible patients (aged 18 –80 y) with hemiplegia caused by AIS were allocated to the group control group. All participants received normal protocol rehabilitation therapy. Patients underwent twice daily for 90 days. The outcome included 90-day Fugl-Meyer Assessment (FMA) scores modified Rankin’s scale (mRS) scores, as well changes angiogenesis-related factors serum from baseline Results: Twenty-seven analysis (13 14 group). There was no significant difference total FMA between two groups. Lower limb at day significantly higher (32.8±8.7 vs. 24.8±5.4, adjusted P =0.042). proportion of favorable (mRS<2) than that group, but detected (8 [61.5%] 7 [50%], =0.705). A increase been found level epidermal growth factor (EGF) (9.4 [1.1 25.7] −8.7 [−15.1 4.7], =0.036) after procedure. Conclusion: This study investigated role plays recovery, especially motor function. may have beneficial effects lower limbs recovery enhancing EGF level. should be further validated future studies.

Язык: Английский

---

Accessibility for Rehabilitation Therapy According to Socioeconomic Status in Patients With Stroke: A Population-Based Retrospective Cohort Study

Brain & Neurorehabilitation, Год журнала: 2023, Номер 16(2)

Опубликована: Янв. 1, 2023

This study aimed to investigate accessibility for rehabilitation therapy according socioeconomic status (SES) after stroke using nationwide population-based cohort data. We selected patients with a diagnosis (International Classification of Diseases, 10th Revision code: I60-64) and SES including residential area, income level, insurance type were also assessed. Receiving continuous was defined as accumulation "Rehabilitative developmental disorder central nervous system (claim MM105)" more than 41 times. Logistic regression analyses performed the association between odds ratios (ORs) 95% confidence intervals (CIs). A total 18,842 enrolled. Rural area (OR, 0.745; CI, 0.664-0.836) medical aid 0.605; 0.494-0.741) associated lower rate receiving therapy. As when lowest group used reference group, low-middle showed an increased 1.206; 1.020-1.426). Although is covered national health program in Korea, there still existed disparities SES. Our results would suggest helpful information policy stroke.

Язык: Английский

---

Progress in the clinical application of constraint-induced therapy following stroke since 2014

Frontiers in Neurology, Год журнала: 2023, Номер 14

Опубликована: Май 19, 2023

Stroke is a group of cerebrovascular diseases with high prevalence and mortality rate. can induce many impairments, including motor cognitive dysfunction, aphasia/dysarthria, dysphagia, mood disorders, which may reduce the quality life among patients. Constraint-induced therapy has been proven to be an effective treatment method for stroke rehabilitation. It widely used in recovery limb aphasia, other impairment like unilateral neglect after stroke. In recent years, constraint-induced also combine telehealth home addition, produces significant neuroplastic changes central nervous system. Functional magnetic resonance imaging, diffusion tensor imaging/electrophysiology methods have clarify mechanism neuroplasticity. However, some limitations. only under certain conditions, time effectiveness are controversial. Further research needed CI therapy.

Язык: Английский

---

A Singularity-Free Approach for Safe Operation of a Parallel Robot for Lower Limb Rehabilitation

Mechanisms and machine science, Год журнала: 2023, Номер unknown, С. 141 - 149

Опубликована: Янв. 1, 2023

Язык: Английский

---

Neurobiomechanical mechanism of Tai Chi to improve upper limb coordination function in post-stroke patients: a study protocol for a randomized controlled trial

Trials, Год журнала: 2023, Номер 24(1)

Опубликована: Дек. 4, 2023

Abstract Background Upper limb dysfunction seriously affects the ability of stroke patients to perform activities daily living. As a popular exercise therapy, Tai Chi may become an alternative intervention. However, neurophysiological mechanism by which improves upper in is still unclear, limits its further promotion and application. Therefore, conducting strict randomized clinical trial necessary observe how explore mechanism. Methods/design This report describes randomized, parallel-controlled with distributive concealment evaluator blinding. A total 84 eligible participants will be randomly assigned group or control 1:1 ratio. The receive 4 weeks training: five 60-min sessions week for 20 sessions. not training. Both groups medical treatment routine rehabilitation primary outcome measure mean change Fugl-Meyer Assessment Extremity (FMA-UE) scale score between baseline weeks; secondary outcomes are changes kinematic characteristics Wolf Motor Function Test (WMFT) Stroke Impact Scale (SIS) scores. In addition, corticomuscular coupling level near-infrared brain functional imaging monitored function patients. Discussion controlled examine effectiveness Positive results verify that can improve Trial registration Chinese Clinical Registration Center, ChiCTR2200061376 (retrospectively registered). Registered June 22, 2022. http://www.chictr.org.cn/listbycreater.aspx . Manuscript Version: 3.0 Date: October 10, 2023.

Язык: Английский

---