The effect of cognitive emotion regulation on direct-acting antivirals adherence in patients with hepatitis C DOI Creative Commons
Adina Turcu-Ştiolică,

Irina Paula Doica,

Bogdan Silviu Ungureanu

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 5, 2024

Introduction Adherence to direct-acting antivirals (DAAs) could be a predictor of chronic viral hepatitis C (HCV) therapeutic failure. We examined the perceptions patients receiving DAAs determine how cognitive factors influence their decision maintain adherence. Also, we explored threshold adherence for obtaining sustained virologic response (SVR) among with HCV, in order better implement strategy that improves future clinical practice. Methods A single-arm prospective study was performed. Patients HCV started and completed treatment County Hospital Craiova, Dolj, Romania, were enrolled. Patients’ medication assessed using HCV-AD10 questionnaire, emotion regulation measured CERQ questionnaire (five positive/adaptive emotion-regulation domains four negative/maladaptive domains). Spearman correlation analysis conducted explore relationships between different factors. ROC-curves used evaluate achieve SVR. linear regression model performed analyze primary outcome (DAAs adherence) target variable based on given independent variables (age, duration, severity nine adaptive maladaptive strategies). Results 368 (mean age: 61 years) diagnosed 4.05 ± 6.38 (average) years ago Mean (±SD) via 91.51 8.34, proportion participants achieving SVR 96%. an less than 84% (5 patients, 1.36%) considered nonadherent they have high probability not (sensitivity specificity 83% 80%, respectively). obtained significantly higher values three strategies adherent following treatment: positive refocusing ( p -value = 0.044), refocus planning 0.037), reappraisal 0.047). Discussion The interplay enhancement contributes more holistic comprehension patient behavior context treatment. Increasing goal setting assisting establishing specific, achievable goals can crucial clinicians aiming improve patients.

Язык: Английский

Impact of a minimal monitoring HCV treatment approach on Health-Related Quality of Life DOI
Thiago S. Torres, Pooja T. Saha, Laura Smeaton

и другие.

Quality of Life Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Язык: Английский

Процитировано

0
Adherence in Hepatitis C Virus Treatment: What We Know DOI

Steven L. Flamm,

Alessandra Mangia

Seminars in Liver Disease, Год журнала: 2024, Номер 44(02), С. 258 - 271

Опубликована: Апрель 24, 2024

Although therapy with direct-acting antiviral (DAA) agents achieves high hepatitis C virus (HCV) cure rates and is forgiving of missed doses, certain patient populations, such as people who inject drugs (PWID), are often denied because a perceived risk nonadherence. However, relationship between adherence to DAAs for various populations efficacy has not been well defined. The lack standardized method evaluating complicates making comparisons studies, it difficult develop implement novel measures that may improve adherent behavior. Traditional methods assessing overestimate medication adherence, while newer, technology-based assist accurately maintaining therapy. Data demonstrate special patients HCV, PWID, can be successfully treated, relatively sustained virologic response (SVR) despite less-than-optimal adherence. While subsequently SVR, improved, should withheld fear This article addresses forgiveness DAA regimens, sofosbuvir/velpatasvir glecaprevir/pibrentasvir, in different HCV. Considerations HCV available detailed.

Язык: Английский

Процитировано

1
Beliefs of patients who visited community pharmacies about medicines and supplements, the need for drug therapy and medication adherence – a cross-sectional study DOI Creative Commons
Etidal-Mihaela Manoliu-Hamwi, Cristina Gena Dascălu, Cristina Mihaela Ghiciuc

и другие.

Journal of Pharmaceutical Policy and Practice, Год журнала: 2024, Номер 17(1)

Опубликована: Дек. 18, 2024

Beliefs about medicines, the need for drug therapy and patient willingness can influence medication adherence. The community pharmacist, through his skills as an expert in therapy, has opportunity to promote adherence everyday pharmaceutical practice. This study aims assess beliefs medicines supplements of patients who visited pharmacies. 809 volunteers answered a 14-item online questionnaire using 5-point Likert scale. Statistical analysis was done SPSS 27.0. validity indices were acceptable; internal consistency good; factor indicated 3 factors (Eigen values > 1.0). median scores 3.33 regarding supplements; 2.75 therapy; 2.71 on supplements, varied according patients' socio-demographic status, health access pharmacy services (p ≤ 0.05). Patients' moderate, negative good.

Язык: Английский

Процитировано

1
The effect of cognitive emotion regulation on direct-acting antivirals adherence in patients with hepatitis C DOI Creative Commons
Adina Turcu-Ştiolică,

Irina Paula Doica,

Bogdan Silviu Ungureanu

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 5, 2024

Introduction Adherence to direct-acting antivirals (DAAs) could be a predictor of chronic viral hepatitis C (HCV) therapeutic failure. We examined the perceptions patients receiving DAAs determine how cognitive factors influence their decision maintain adherence. Also, we explored threshold adherence for obtaining sustained virologic response (SVR) among with HCV, in order better implement strategy that improves future clinical practice. Methods A single-arm prospective study was performed. Patients HCV started and completed treatment County Hospital Craiova, Dolj, Romania, were enrolled. Patients’ medication assessed using HCV-AD10 questionnaire, emotion regulation measured CERQ questionnaire (five positive/adaptive emotion-regulation domains four negative/maladaptive domains). Spearman correlation analysis conducted explore relationships between different factors. ROC-curves used evaluate achieve SVR. linear regression model performed analyze primary outcome (DAAs adherence) target variable based on given independent variables (age, duration, severity nine adaptive maladaptive strategies). Results 368 (mean age: 61 years) diagnosed 4.05 ± 6.38 (average) years ago Mean (±SD) via 91.51 8.34, proportion participants achieving SVR 96%. an less than 84% (5 patients, 1.36%) considered nonadherent they have high probability not (sensitivity specificity 83% 80%, respectively). obtained significantly higher values three strategies adherent following treatment: positive refocusing ( p -value = 0.044), refocus planning 0.037), reappraisal 0.047). Discussion The interplay enhancement contributes more holistic comprehension patient behavior context treatment. Increasing goal setting assisting establishing specific, achievable goals can crucial clinicians aiming improve patients.

Язык: Английский

Процитировано

0