Antihypertensive Effects of Quercetin-Rich Marchin-13 in a Dexamethasone-Induced Rat Model DOI Open Access
Anu Altangerel, Chimedragchaa Chimedtseren, Myadagbadam Urtnasan

и другие.

Biomedical & Pharmacology Journal, Год журнала: 2024, Номер 17(4), С. 2565 - 2574

Опубликована: Дек. 30, 2024

The study aimed to evaluate the antihypertensive effect of Marchin-13 traditional prescription (M13T) in dexamethasone-induced model hypertension. Quercetin, a biologically active substance contained M13T, was identified by HPLC analysis. Forty rats were randomly assigned five different groups. experimental groups induced hypertension models dexamethasone (20 mcg/kg/day). Blood pressure assessed tail with Neurobotic Systole 1.2 instrument on days 5, 8, 13, and 15. serum levels renin, ANGII, aldosterone, AT1R measured all ELISA. Our research determined that quercetin content M13T is 0.255 mg/g. In model, significantly reduced SBP, DBP, MAP 15 (p < 0.01). Moreover, AT1R, aldosterone captopril compared DEX group As result our study, has an reducing angiotensin II, hypertensive dexamethasone.

Язык: Английский

Antihypertensive Effects of Quercetin-Rich Marchin-13 in a Dexamethasone-Induced Rat Model DOI Open Access
Anu Altangerel, Chimedragchaa Chimedtseren, Myadagbadam Urtnasan

и другие.

Biomedical & Pharmacology Journal, Год журнала: 2024, Номер 17(4), С. 2565 - 2574

Опубликована: Дек. 30, 2024

The study aimed to evaluate the antihypertensive effect of Marchin-13 traditional prescription (M13T) in dexamethasone-induced model hypertension. Quercetin, a biologically active substance contained M13T, was identified by HPLC analysis. Forty rats were randomly assigned five different groups. experimental groups induced hypertension models dexamethasone (20 mcg/kg/day). Blood pressure assessed tail with Neurobotic Systole 1.2 instrument on days 5, 8, 13, and 15. serum levels renin, ANGII, aldosterone, AT1R measured all ELISA. Our research determined that quercetin content M13T is 0.255 mg/g. In model, significantly reduced SBP, DBP, MAP 15 (p < 0.01). Moreover, AT1R, aldosterone captopril compared DEX group As result our study, has an reducing angiotensin II, hypertensive dexamethasone.

Язык: Английский

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