One‐Pot, Multicomponent Synthesis of 1,3‐Oxazin‐One and Evaluation of Their Potential Antioxidant Activities DOI Open Access

Phitovili Sumi,

Betokali K. Zhimomi,

Manthae Phom

и другие.

Journal of Heterocyclic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

ABSTRACT The synthesis of 1,3‐oxazines from 2‐naphthol, benzaldehyde, and urea is reported using a simple efficient microwave‐assisted protocol. SiO 2 ‐ZnCl employed for the first time to synthesize library 10 oxazin‐3‐one compounds, out which five derivatives are novel. In 30–60 s products were obtained with simplified work‐up, yield purity enhanced, reaction was reduced use microwave assistance. synthesized oxazines characterized evaluated their in vitro antioxidant properties. results demonstrated significant effective presence capabilities. compound 1‐(4‐hydroxy‐3‐methoxyphenyl)‐1,2‐dihydro‐3 H ‐naphtho[1,2‐ e ][1,3]oxazin‐3‐one, containing hydroxy methoxy groups, revealed superior activity.

Язык: Английский

Synthesis and characterization of functionalized nano NaY zeolite with metformin and use for the synthesis of 2-amino-4H-chromenes DOI
Niloofar Haghdadi, Sakineh Asghari, Ghasem Firouzzadeh Pasha

и другие.

Research on Chemical Intermediates, Год журнала: 2024, Номер 50(5), С. 1961 - 1992

Опубликована: Март 18, 2024

Язык: Английский

Процитировано

0
One-pot multicomponent approach towards the synthesis of 5-substituted 1H-tetrazoles using lanthanum (III) nitrate hexahydrate as a catalyst DOI
Kumaraswamy Gullapelli,

Nukala Ramesh,

Saidulu Ganji

и другие.

Research on Chemical Intermediates, Год журнала: 2024, Номер 50(9), С. 4407 - 4423

Опубликована: Июль 31, 2024

Язык: Английский

Процитировано

0
Advanced Catalytic Syntheses of 1,3-Oxazine Derivatives via Electrophilic Substitution Using Mono- and Bimetallic Phosphate Catalysts: Co₃(PO 4 ) 2 and CoCa 3 (HPO 4 )(PO 4 ) 2 (OH) DOI Creative Commons
Achraf El Hallaoui, Nouhaila Ferraa,

Yousssef MERROUN

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 2, 2024

Abstract This research introduces a novel catalytic approach for the synthesis of 1,3-oxazinone derivatives through multicomponent reaction that relies on an electrophilic substitution mechanism, employing two cobalt-based phosphate catalysts. approach, allowed us to synthesize oxazine derivatives, known their significant biological activities, achieving impressive yields up 97% in remarkably short time only 7 minutes, all under conditions environmentally friendly according principles green chemistry using ethanol/water mixture as solvent. In our study, we utilized catalysts derived from cobalt-modified phosphate, which were synthesized laboratory simple methods. The first support consists monometallic catalyst, denoted Co3(PO4)2, whereas second is bimetallic catalyst modified with cobalt and calcium CoCa3(HPO4)(PO4)2(OH). Our developed methods had various advantages including simplicity process, rapid time, clean-up, ability recover reuse overall simplicity. All these render this effective viable synthesizing suitable large-scale applications.

Язык: Английский

Процитировано

0
Advanced Catalytic Approaches for Synthesizing 1,2-dihydro-1-aryl-3H-naphtho[1,2-e]-[1,3]oxazin-3-one Derivatives through Electrophilic Substitution Reactions using Mono- and Bimetallic Phosphate Catalysts: A Study of Co₃(PO₄)₂ and CoCa₃(HPO₄)(PO₄)₂(OH) DOI Creative Commons
Achraf El Hallaoui, Nouhaila Ferraa,

Yousssef MERROUN

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 7, 2024

Abstract This research introduces a novel catalytic approach for the synthesis of 1,3-oxazinone derivatives through multicomponent reaction that relies on an electrophilic substitution mechanism, employing two cobalt-based phosphate catalysts. approach, allowed us to synthesize oxazine derivatives, known their significant biological activities, achieving impressive yields up 97% in remarkably short time only 7 minutes, all under conditions environmentally friendly according principles green chemistry using ethanol/water mixture as solvent. In our study, we utilized catalysts derived from cobalt-modified phosphate, which were synthesized laboratory simple methods. The first support consists monometallic catalyst, denoted Co3(PO4)2, whereas second is bimetallic catalyst modified with cobalt and calcium CoCa3(HPO4)(PO4)2(OH). Our developed methods had various advantages including simplicity process, rapid time, clean-up, ability recover reuse overall simplicity. All these render this effective viable synthesizing suitable large-scale applications.

Язык: Английский

Процитировано

0
One‐Pot, Multicomponent Synthesis of 1,3‐Oxazin‐One and Evaluation of Their Potential Antioxidant Activities DOI Open Access

Phitovili Sumi,

Betokali K. Zhimomi,

Manthae Phom

и другие.

Journal of Heterocyclic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

ABSTRACT The synthesis of 1,3‐oxazines from 2‐naphthol, benzaldehyde, and urea is reported using a simple efficient microwave‐assisted protocol. SiO 2 ‐ZnCl employed for the first time to synthesize library 10 oxazin‐3‐one compounds, out which five derivatives are novel. In 30–60 s products were obtained with simplified work‐up, yield purity enhanced, reaction was reduced use microwave assistance. synthesized oxazines characterized evaluated their in vitro antioxidant properties. results demonstrated significant effective presence capabilities. compound 1‐(4‐hydroxy‐3‐methoxyphenyl)‐1,2‐dihydro‐3 H ‐naphtho[1,2‐ e ][1,3]oxazin‐3‐one, containing hydroxy methoxy groups, revealed superior activity.

Язык: Английский

Процитировано

0