Chiral Phosphoric Acid-Catalyzed Hydrolytic Parallel Kinetic Resolution of Racemic Epoxides and Activated Alcohols

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

We report a chiral phosphoric acid-catalyzed hydrolytic parallel kinetic resolution (HPKR) of racemic epoxides and activated alcohols. Using an acyloxy-assisted activation strategy, this method enables the highly stereocontrolled hydrolysis under mild conditions. A wide range aryl-substituted secondary alcohols were effectively transformed, providing corresponding with combined yields up to 99% enantiomeric ratios exceeding 99:1.

Язык: Английский

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Asymmetric Magnesium Catalysis for Important Chiral Scaffolds Synthesis

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(24), С. 4778 - 4800

Опубликована: Янв. 1, 2024

A review is presented of magnesium catalysis for the synthesis important chiral scaffolds. Several motifs that are present in classic ligands or natural products synthesized by Mg( ii ) catalytic methods briefly discussed.

Язык: Английский

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璀璨元素：中国元素化学快讯

Chinese Science Bulletin (Chinese Version), Год журнала: 2024, Номер 69(23), С. 3352 - 3353

Опубликована: Авг. 1, 2024

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