Nanosecond multipulse retinal damage thresholds of elongated irradiance profiles in explant measurements and simulations DOI Creative Commons
M. J. Herbst, Sebastian Kotzur, Annette Frederiksen

и другие.

Journal of Biomedical Optics, Год журнала: 2023, Номер 28(12)

Опубликована: Дек. 2, 2023

SignificanceThe database for multipulse retinal damage thresholds the laser safety standard (IEC 60825-1:2014) is confined, especially elongated irradiation profiles. To ensure eye safety, (ED50 values) need to be determined.AimThis study aims examine nanosecond scenarios.ApproachTo determine ED50 values in ex vivo measurements, an optical setup presented. Porcine explant tissue irradiated with rectangular top-hat Thermal simulations are carried out on a validated computer model and injury obtained.ResultsThe measurements resulted from 8.46 42.72 μJ slope 1.15 1.4. A thermal can excluded due level value combination different type of declining behavior increasing pulses compared simulations. dependence elongation or area image emerges but could not confirmed influencing factors (biological variability, focusing, measuring procedure).ConclusionsUsing slit apertures beam shaping, variable spot geometries realized without changing elements setup. For further evaluation profiles, additional improve measurement accuracy necessary.

Язык: Английский

Nanosecond multipulse retinal damage thresholds of elongated irradiance profiles in explant measurements and simulations DOI Creative Commons
M. J. Herbst, Sebastian Kotzur, Annette Frederiksen

и другие.

Journal of Biomedical Optics, Год журнала: 2023, Номер 28(12)

Опубликована: Дек. 2, 2023

SignificanceThe database for multipulse retinal damage thresholds the laser safety standard (IEC 60825-1:2014) is confined, especially elongated irradiation profiles. To ensure eye safety, (ED50 values) need to be determined.AimThis study aims examine nanosecond scenarios.ApproachTo determine ED50 values in ex vivo measurements, an optical setup presented. Porcine explant tissue irradiated with rectangular top-hat Thermal simulations are carried out on a validated computer model and injury obtained.ResultsThe measurements resulted from 8.46 42.72 μJ slope 1.15 1.4. A thermal can excluded due level value combination different type of declining behavior increasing pulses compared simulations. dependence elongation or area image emerges but could not confirmed influencing factors (biological variability, focusing, measuring procedure).ConclusionsUsing slit apertures beam shaping, variable spot geometries realized without changing elements setup. For further evaluation profiles, additional improve measurement accuracy necessary.

Язык: Английский

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