Hemoglobin detection in blood samples using a graphene-based surface plasmon resonance biosensor

Optik, Год журнала: 2022, Номер 270, С. 169947 - 169947

Опубликована: Сен. 12, 2022

Язык: Английский

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Highly Sensitive TiO2/Au/Graphene Layer-Based Surface Plasmon Resonance Biosensor for Cancer Detection

Biosensors, Год журнала: 2022, Номер 12(8), С. 603 - 603

Опубликована: Авг. 5, 2022

In this article, a hybrid TiO2/Au/graphene layer-based surface plasmon resonance (SPR) sensor with improved sensitivity and capability for cancer detection is presented. The finite element method (FEM) was used numerical analysis. proposed SPR biosensor structured based on the angular analysis of attenuated total reflection (ATR) various types using refractive index component. angle shifted owing to increment normal cancerous cells' index, which varied between 1.36 1.401 six different cells. According results, obtained sensitivities skin (basal), cervical (HeLa), adrenal gland (PC12), blood (Jurkat), breast (MCF-7 MDA-MB-231) cells were 210 deg/RIU, 245.83 264.285 285.71 292.86 278.57 respectively. Furthermore, accuracy (DA), figure merits (FOM), signal-to-noise ratio (SNR) also obtained, values 0.263 deg-1, 48.02 RIU-1, 3.84, Additionally, distribution electric field propagation magnetic resonant non-resonant conditions structure illustrated. It found that an enhanced exhibited plasmonic material conditions. We measured penetration depth 180 nm decayed intensity. impact layer demonstrated. further conducted analyses effects thickness gold additional graphene layers overall cancer. layered highest in terms detecting from healthy Moreover, numerically analyzed wide range biological solutions (refractive 1.33-1.41), linearity calculated linear regression coefficient (R2) 0.9858. Finally, results manuscript high comparison previously reported studies.

Язык: Английский

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Plasmonic refractive index sensing in the early diagnosis of diabetes, anemia, and cancer: An exploration of biological biomarkers

Results in Physics, Год журнала: 2023, Номер 49, С. 106478 - 106478

Опубликована: Апрель 26, 2023

This article presents a novel refractive index nanosensor based on metal–insulator–metal (MIM) waveguide that incorporates silver nanorod embedded in rectangular resonator with two baffles. The suggested sensor has great potential the medical field for early disease diagnosis and research, as it can detect identify many biological components by using interdependence between resulting change resonant wavelength. To perform numerical calculation, finite element method been utilized. maximum sensitivity of is recorded 2963.73 nm per unit (RIU), figure merit (FOM) sensing resolution 25.1 3.37×10−7 RIU, respectively. high precision make capable detecting glucose concentration distinguishing different degrees diabetes. Additionally, measure hemoglobin concentration, which useful classifying anemia into categories. information be vital factor identifying severity level taking appropriate measures. sensor's performance facilitates differentiation healthy cells from cancerous ones, making an essential tool detection cancer. Furthermore, to brain blood, may pave way future research development medicine.

Язык: Английский

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Highly Sensitive Bimetallic-Metal Nitride SPR Biosensor for Urine Glucose Detection

IEEE Transactions on NanoBioscience, Год журнала: 2023, Номер 22(4), С. 897 - 903

Опубликована: Фев. 20, 2023

The present study introduces a highly sensitive bimetallic SPR biosensor based on metal nitride for efficient urine glucose detection. Using BK-7 prism, Au (25 nm), Ag (25nm), AlN (15 and biosample (urine) layer, the proposed sensor comprises of five layers. selection sequence dimensions both layers is their performance in number case studies including monometallic After optimizing layer as nm) - various were used to further increase sensitivity by utilizing synergistic effect through several samples, ranging from nondiabetic severely diabetic patients. determined be best suited material, its thickness optimized 15 nanometers. structure has been evaluated using visible wavelength, i.e., λ = 633 nm, order while providing room low-cost prototyping. With parameters optimized, significant 411°/RIU (Refractive Index Unit) figure merit (FoM) 105.38 /RIU achieved. computed resolution 4.17e-06. This study's findings have also compared some recently reported results. would useful detecting concentrations, with rapid response measured substantial shift resonance angle curves.

Язык: Английский

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Platinum Diselenide and Graphene-Based Refractive Index Sensor for Cancer Detection

Plasmonics, Год журнала: 2023, Номер 19(2), С. 953 - 962

Опубликована: Сен. 14, 2023

Язык: Английский

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Tuning sensitivity of bimetallic, MXene and graphene-based SPR biosensors for rapid malaria detection: a numerical approach

Journal of Computational Electronics, Год журнала: 2024, Номер 23(4), С. 920 - 929

Опубликована: Июнь 17, 2024

Язык: Английский

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Gold, MXene, and graphene nanofilm-based surface plasmon resonance sensor for malaria detection

Journal of Optics, Год журнала: 2024, Номер unknown

Опубликована: Фев. 18, 2024

Язык: Английский

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Design and development of graphene-based double split ring resonator metasurface biosensor using MgF2-gold materials for blood cancer detection

Optical and Quantum Electronics, Год журнала: 2024, Номер 56(7)

Опубликована: Май 25, 2024

Язык: Английский

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Bimetal Thin Film, Semiconductors, and 2D Nanomaterials in SPR Biosensors: An Approach to Enhanced Urine Glucose Sensing

IEEE Transactions on NanoBioscience, Год журнала: 2024, Номер 23(2), С. 336 - 343

Опубликована: Янв. 15, 2024

This work introduces a systematic approach for the development of Kretschmann configuration-based biosensors designed non-invasive urine glucose detection. The methodology encompasses utilization various semiconductors, including Silicon (Si), Germanium (Ge), Gallium Nitride (GaN), Aluminum (AlN), and Indium (InN), in combination with bimetallic layer (comprising Au Ag films equal thickness) to enhance biosensor sensitivity. Additionally, 2D nanomaterials, such as Black Phosphorus Graphene, are integrated into semiconductor layers performance further. These configurations meticulously optimized through application transfer matrix method (TMM), sensing parameters assessed using angular modulation method. Among AlN GaN exhibit superior results. On these substrates, Graphene phosphorous (BP) applied, resulting four final structures (thicknesses nm): BK7/Au(26)/Ag(26)/Si(6)/BP(0.53)/Biosample, BK7/Au(26)/Ag(26)/AlN(14)/BP(0.53)/Biosample, BK7/Au(26)/Ag(26)/GaN(12)/BP(0.53)/Biosample, BK7/Au(26)/Ag(26)/GaN(12)/Graphene(0.34)/Biosample. achieve Sensitivity(° /RIU) Figure Merit (FoM) (1/RIU) 380, 360, 440, 400, 58.5, 90, 90.65, 82.4, respectively. Subsequently, high-performing sensors undergo testing actual samples. them, two biosensors, BK7/Au(26)/Ag(26)/AlN(14)/BP (0.53)/Biosample BK7/Au(26)/Ag(26)/GaN(14)/Graphene(0.34)/Biosample, outstanding performance, sensitivities (° FoM 394.44 & 294.44, 112.6 92.01 A comparison is also made relevant previously published work, revealing improved

Язык: Английский

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Development of an advanced multimode refractive index plasmonic optical sensor utilizing split ring resonators for brain cancer cell detection

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 2, 2025

Язык: Английский

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