Mice alternate between discrete strategies during perceptual decision-making

Nature Neuroscience, Год журнала: 2022, Номер 25(2), С. 201 - 212

Опубликована: Фев. 1, 2022

Язык: Английский

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Shifting attention between perception and working memory

Cognition, Год журнала: 2024, Номер 245, С. 105731 - 105731

Опубликована: Янв. 25, 2024

Most everyday tasks require shifting the focus of attention between sensory signals in external environment and internal contents working memory. To date, shifts have been investigated within each domain, but domain remain poorly understood. We developed a combined perception working-memory task to investigate compare consequences spatial domains service common orientation-reproduction task. Participants were sequentially cued attend items either memory or an upcoming stimulation. Stay trials provided baseline condition, while shift required participants their another item same different domain. Validating our experimental approach, we found evidence that shifted effectively (Experiment 1). In addition, observed greater costs when transitioning as compared (Experiments 1, 2). Strikingly, these persisted even given more time complete attentional Biases fixational gaze behaviour tracked orienting both domains, revealed no latency magnitude difference for within- versus between-domain Collectively, results from Experiments 1 2 suggest might be regulated by unique control function. Our break new ground exploring ubiquitous act guide adaptive cognition.

Язык: Английский

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An integrative view of the role of prefrontal cortex in consciousness

Neuron, Год журнала: 2024, Номер 112(10), С. 1626 - 1641

Опубликована: Май 1, 2024

Язык: Английский

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N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference

Brain, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Perception integrates external sensory signals with internal predictions that reflect prior knowledge about the world. Previous research suggests this integration is governed by slow alternations between an mode, driven signals, and shaped knowledge. Using a double-blind, placebo-controlled, cross-over experiment in healthy human participants, we investigated effects of N-Methyl-D-aspartate receptor (NMDAR) antagonist S-ketamine on balance modes. We found causes shift perception toward mode. A case-control study revealed individuals paranoid Scz, disorder repeatedly associated NMDAR hypofunction, spend more time This NMDAR-dependent increase mode symptoms schizophrenia are caused recurring dissociations from

Язык: Английский

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Disentangling sources of variability in decision-making

Nature reviews. Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Язык: Английский

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Strategic stabilization of arousal boosts sustained attention

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2022, Номер unknown

Опубликована: Март 6, 2022

Summary Changes in autonomic arousal, such as mounting sleep pressure, and changes motivation, fluctuating environmental reward statistics, both profoundly influence behavior. Our experience tells us that we have some capacity to control our arousal when doing so is important, staying awake while driving a motor vehicle. However, little known about how decision computations are jointly influenced by including whether animals, rodents, can adapt their state needs. Here, developed show results from an auditory feature-based sustained-attention task with intermittently shifting utility. We use pupil size estimate across wide range of states apply novel signal detection theoretic accumulation-to-bound modeling approaches large behavioral cohort. find pupil-linked utility major impacts on multiple aspects performance. Although substantial fluctuations persist conditions, mice partially stabilize near intermediate, optimal, level high. Behavioral analyses elements behavior improve during high influences some, but not all, them. Specifically, the likelihood timescale sensory evidence accumulation, quantity accumulated per time step attending. In sum, establish specific decision-computational signatures interaction, attention. So doing, provide experimental analysis framework for studying self-regulation neurotypical brains diseases attention-deficit/hyperactivity disorder.

Язык: Английский

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Pre-stimulus alpha oscillations encode stimulus-specific visual predictions

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 14, 2024

Abstract Predictions of future events have a major impact on how we process sensory signals. However, it remains unclear the brain keeps predictions online in anticipation inputs. Here, combined magnetoencephalography (MEG) and multivariate decoding techniques to investigate content perceptual their frequency characteristics. Participants were engaged shape discrimination task, while auditory cues predicted which specific would likely appear. Frequency analysis revealed significant oscillatory fluctuations representations pre-stimulus window alpha band (10 – 11Hz). Furthermore, found that this stimulus-specific power was linked expectation effects discrimination. Our findings demonstrate are embedded oscillations modulate subsequent performance, providing neural mechanism through deploys predictions.

Язык: Английский

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Where is the ghost in the shell?

Neuroscience of Consciousness, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

The neurobiology of conscious experience is one the fundamental mysteries in science. New evidence suggests that transcranial magnetic stimulation parietal cortex does not modulate bistable perception. What this mean for neural correlates consciousness, and how should we search them?

Язык: Английский

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N-Methyl-D-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 24, 2024

Perception alternates between an external mode, driven by sensory inputs, and internal shaped prior knowledge. We found that the mode is more prevalent during pharmacologically induced N-Methyl-D-aspartate receptor (NMDAR) hypofunction in schizophrenia. This NMDAR-dependent increase suggests psychotic experiences are caused recurring dissociations of perception from knowledge about world.

Язык: Английский

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Strategic stabilization of arousal boosts sustained attention

Current Biology, Год журнала: 2024, Номер 34(18), С. 4114 - 4128.e6

Опубликована: Авг. 15, 2024

Arousal and motivation interact to profoundly influence behavior. For example, experience tells us that we have some capacity control our arousal when appropriately motivated, such as staying awake while driving a motor vehicle. However, little is known about how jointly decision computations, including if animals, rodents, adapt their state needs. Here, developed show results from an auditory, feature-based, sustained-attention task with intermittently shifting utility. We use pupil size estimate across wide range of states apply tailored signal-detection theoretic, hazard function, accumulation-to-bound modeling approaches in large cohort mice. find pupil-linked utility both major impacts on multiple aspects performance. Although substantial fluctuations persist conditions, mice partially stabilize near intermediate optimal level high. Behavioral analyses elements behavior improve during high influences some, but not all, them. Specifically, the likelihood timescale sensory evidence accumulation quantity accumulated per time step attending. In sum, establish specific decision-computational signatures arousal, motivation, interaction attention. So doing, provide experimental analysis framework for studying self-regulation neurotypical brains diseases attention-deficit/hyperactivity disorder.

Язык: Английский

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