Activity-dependent lateral inhibition enables the synchronization of olfactory bulb projection neurons DOI Open Access

Tal Dalal,

Rafi Haddad

Опубликована: Дек. 24, 2024

Information in the brain is represented by activity of neuronal ensembles. These ensembles are adaptive and dynamic, formed truncated based on animal’s experience. One mechanism which spatially distributed neurons form an ensemble synchronizing their spike times response to a sensory event. In olfactory bulb, odor stimulation evokes rhythmic gamma mitral tufted cells (MTCs). This thought enhance relay information downstream targets. However, how specifically odor-activated MTCs synchronized unknown. Here, we demonstrate that optogenetic activation one set can gamma-entrain spiking another set. lateral synchronization was particularly effective when recorded MTC fired at rhythm, facilitating only substantially active MTCs. Furthermore, show did not depend distance between mediated granule-cell layer neurons. contrast, inhibition reduced firing rates restricted adjacent dissociation these two interaction types suggests they different neural circuits. Our findings propose simple yet robust entrain each other ensemble.

Язык: Английский

Activity-dependent lateral inhibition enables ensemble synchronization of odor-activated neurons in the olfactory bulb DOI Creative Commons

Tal Dalal,

Rafi Haddad

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 2, 2024

Abstract Information in the brain is represented by activity of neuronal ensembles. These ensembles are adaptive and dynamic, formed truncated based on animal’s experience. One mechanism which spatially distributed neurons form an ensemble synchronizing their spike times response to a sensory event. In olfactory bulb, odor stimulation evokes rhythmic gamma mitral tufted cells (MTCs). This thought enhance relay information downstream targets. However, how specifically odor-activated MTCs synchronized unknown. Here, we demonstrate that optogenetic activation one set can gamma-entrain spiking another set. lateral synchronization was particularly effective when recorded MTC fired at rhythm, facilitating only substantially active MTCs. Furthermore, show did not depend distance between mediated granule-cell layer neurons. contrast, inhibition reduced firing rates restricted adjacent dissociation these two interaction types suggests they different neural circuits. Our findings propose simple yet robust entrain each other ensemble. Highlights entrains timing activity-dependent distance-independent manner. suppression activity- distance-dependent Spatially Granule cell control MTC’s timing, do affect odor-evoked rate.

Язык: Английский

Процитировано

0
Activity-dependent lateral inhibition enables the synchronization of olfactory bulb projection neurons DOI Open Access

Tal Dalal,

Rafi Haddad

Опубликована: Дек. 24, 2024

Information in the brain is represented by activity of neuronal ensembles. These ensembles are adaptive and dynamic, formed truncated based on animal’s experience. One mechanism which spatially distributed neurons form an ensemble synchronizing their spike times response to a sensory event. In olfactory bulb, odor stimulation evokes rhythmic gamma mitral tufted cells (MTCs). This thought enhance relay information downstream targets. However, how specifically odor-activated MTCs synchronized unknown. Here, we demonstrate that optogenetic activation one set can gamma-entrain spiking another set. lateral synchronization was particularly effective when recorded MTC fired at rhythm, facilitating only substantially active MTCs. Furthermore, show did not depend distance between mediated granule-cell layer neurons. contrast, inhibition reduced firing rates restricted adjacent dissociation these two interaction types suggests they different neural circuits. Our findings propose simple yet robust entrain each other ensemble.

Язык: Английский

Процитировано

0