The Power of Neuroglia in Driving Brain Function

Neurochemical Research, Год журнала: 2025, Номер 50(3)

Опубликована: Июнь 1, 2025

Язык: Английский

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Distinct UPR and Autophagic Functions Define Cell-Specific Responses to Proteotoxic Stress in Microglial and Neuronal Cell Lines

Cells, Год журнала: 2024, Номер 13(24), С. 2069 - 2069

Опубликована: Дек. 15, 2024

Autophagy is a catabolic process involved in different cellular functions. However, the molecular pathways governing its potential roles cell types remain poorly understood. We investigated role of autophagy context proteotoxic stress two central nervous system types: microglia-like line BV2 and neuronal-like N2a. Proteotoxic stress, induced by proteasome inhibition, produced early apoptosis cells, due part to predominant activation PERK-CHOP pathway. In contrast, N2a cells showcased greater resistance robust induction IRE1α-sXbp1 arm UPR. also demonstrated that activated both lines but with kinetics restored proteostasis, while it participated regulating phagocytosis. Finally, predominantly mTORC2-AKT-FOXO1-β-catenin pathway preferentially PDK1-AKT-FOXO3 axis. Collectively, our findings suggest triggers cell-specific responses microglia neurons, physiological outcomes.

Язык: Английский

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Microglia cannibalism during neurodevelopment results in necroptotic cell death

PLoS Biology, Год журнала: 2024, Номер 22(10), С. e3002869 - e3002869

Опубликована: Окт. 31, 2024

Clearance of dying neurons by microglia is critical to healthy neurodevelopment, but what else do eat? A new study in PLOS Biology demonstrates that not only eat each other, and this "microglia cannibalism" causes necroptotic cell death.

Язык: Английский

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