Neural Networks, Год журнала: 2024, Номер 180, С. 106714 - 106714
Опубликована: Сен. 7, 2024
Язык: Английский
Nature, Год журнала: 2025, Номер unknown
Опубликована: Апрель 30, 2025
Different theories explain how subjective experience arises from brain activity1,2. These have independently accrued evidence, but not been directly compared3. Here we present an open science adversarial collaboration juxtaposing integrated information theory (IIT)4,5 and global neuronal workspace (GNWT)6-10 via a theory-neutral consortium11-13. The proponents the consortium developed preregistered experimental design, divergent predictions, expected outcomes interpretation thereof12. Human participants (n = 256) viewed suprathreshold stimuli for variable durations while neural activity was measured with functional magnetic resonance imaging, magnetoencephalography intracranial electroencephalography. We found about conscious content in visual, ventrotemporal inferior frontal cortex, sustained responses occipital lateral temporal cortex reflecting stimulus duration, content-specific synchronization between early visual areas. results align some predictions of IIT GNWT, substantially challenging key tenets both theories. For IIT, lack within posterior contradicts claim that network connectivity specifies consciousness. GNWT is challenged by general ignition at offset limited representation certain dimensions prefrontal cortex. challenges extend to other consciousness share tested here14-17. Beyond theories, alternative approach advance cognitive neuroscience through principled, theory-driven, collaborative research highlight need quantitative framework systematic testing building.
Язык: Английский
Процитировано
1
Consciousness and Cognition, Год журнала: 2024, Номер 119, С. 103668 - 103668
Опубликована: Фев. 27, 2024
How deep is the current diversity in panoply of theories to define consciousness, and what extent do these share common denominators? Here we first examine different are commensurable (or comparable) along particular dimensions. We posit logical (and, when applicable, empirical) commensurability as a necessary condition for identifying denominators among theories. By consequence, dimensions inclusion set logically empirically consciousness can be proposed. Next, compare limited subset neuroscience-based terms commensurability. This analysis does not yield denominator that might serve minimally unifying model consciousness. Theories seem akin by one remote another. suggest methodology comparing via multiple probing questions, allowing discern overall (dis)similarities between Despite very background definitions conclude that, if attention paid search methological approach brain-consciousness relationships, it should possible principle overcome Babylonian confusion tongues eventually integrate merge
Язык: Английский
Процитировано
7
eLife, Год журнала: 2024, Номер 12
Опубликована: Июль 18, 2024
How is the information-processing architecture of human brain organised, and how does its organisation support consciousness? Here, we combine network science a rigorous information-theoretic notion synergy to delineate ‘synergistic global workspace’, comprising gateway regions that gather synergistic information from specialised modules across brain. This then integrated within workspace widely distributed via broadcaster regions. Through functional MRI analysis, show correspond brain’s default mode network, whereas broadcasters coincide with executive control network. We find loss consciousness due general anaesthesia or disorders corresponds diminished ability integrate information, which restored upon recovery. Thus, coincides breakdown integration work contributes conceptual empirical reconciliation between two prominent scientific theories consciousness, Global Neuronal Workspace Integrated Information Theory, while also advancing our understanding supports through information.
Язык: Английский
Процитировано
7
Research Square (Research Square), Год журнала: 2023, Номер unknown
Опубликована: Июнь 28, 2023
Abstract Different theories explain how subjective experience arises from brain activity1,2. These have independently accrued evidence, yet, confirmation bias and dependence on design choices hamper progress in the field3. Here, we present an open science adversarial collaboration which directly juxtaposes Integrated Information Theory (IIT)4,5 Global Neuronal Workspace (GNWT)6-10, employing a theory-neutral consortium approach11,12. We investigate neural correlates of content duration visual experience. The theory proponents developed preregistered experimental design, divergent predictions, expected outcomes, their interpretation12. 256 human subjects viewed suprathreshold stimuli for variable durations while activity was measured with functional magnetic resonance imaging, magnetoencephalography, electrocorticography. find information about conscious visual, ventro-temporal inferior frontal cortex, sustained responses occipital lateral temporal cortex reflecting stimulus duration, content-specific synchronization between early areas. results confirm some predictions IIT GNWT, substantially challenging both theories: IIT, lack within posterior contradicts claim that network connectivity specifies consciousness. GNWT is challenged by general ignition at offset limited representation certain dimensions prefrontal cortex. Beyond themselves, alternative approach to advance cognitive neuroscience through principled, theory-driven, collaborative effort. highlight challenges change people’s mind 13 need quantitative framework integrating evidence systematic testing building.
Язык: Английский
Процитировано
14
Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 161, С. 105670 - 105670
Опубликована: Апрель 12, 2024
Consciousness science is marred by disparate constructs and methodologies, making it challenging to systematically compare theories. This foundational crisis casts doubts on the scientific character of field itself. Addressing it, we propose a framework for comparing consciousness theories introducing novel inter-theory classification interface, Measure Centrality Index (MCI). Recognizing its gradient distribution, MCI assesses degree importance specific empirical measure has given theory. We apply probe how measures Global Neuronal Workspace Theory (GNW), Integrated Information (IIT), Temporospatial (TTC) would fare within context other two. demonstrate that direct comparison IIT, GNW, TTC meaningful valid some like Lempel-Ziv Complexity (LZC), Autocorrelation Window (ACW), possibly Mutual (MI). In contrast, problematic others anatomical physiological neural correlates (NCC) due their MCI-based differential weightings structure sum, introduce provide proof-of-principle systematic method comparisons, thereby addressing isolated evolution confirmatory bias issues in state-of-the-art neuroscience consciousness.
Язык: Английский
Процитировано
6
Neuroscience of Consciousness, Год журнала: 2024, Номер 2024(1)
Опубликована: Янв. 1, 2024
Modern medicine has been shaken by the surge of psychedelic science that proposes a new approach to mitigate mental disorders, such as depression and post-traumatic stress disorder. Clinical trials investigate whether substances can treat psychiatric conditions are now underway, yet less discussion gravitates around their use in neurological disorders due brain injury. One suggested implementation brain-complexity enhancing psychedelics is people with post-comatose consciousness (DoC). In this article, we discuss rationale endeavour, examining possible outcomes experiments postulating existence an optimal level complexity. We consider counterintuitive effects both DoC on functional connectivity default mode network its impact selfhood. also elaborate role computational modelling providing complementary information experimental studies, contributing our understanding treatment mechanisms path towards personalized medicine. Finally, update discourse surrounding ethical considerations, encompassing clinical scientific values.
Язык: Английский
Процитировано
6
Trends in Neurosciences, Год журнала: 2024, Номер 47(7), С. 551 - 568
Опубликована: Май 31, 2024
Disentangling how cognitive functions emerge from the interplay of brain dynamics and network architecture is among major challenges that neuroscientists face. Pharmacological pathological perturbations consciousness provide a lens to investigate these complex challenges. Here, we review recent advances about brain's functional organisation have been driven by common denominator: decomposing function into fundamental constituents time, space, information. Whereas unconsciousness increases structure-function coupling across scales, psychedelics may decouple structure. Convergent effects also emerge: anaesthetics, psychedelics, disorders can exhibit similar reconfigurations unimodal-transmodal axis. Decomposition approaches reveal potential translate discoveries species, with computational modelling providing path towards mechanistic integration.
Язык: Английский
Процитировано
5
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2020, Номер unknown
Опубликована: Ноя. 26, 2020
Abstract A central goal of neuroscience is to understand how the brain orchestrates information from multiple input streams into a unified conscious experience. Here, we address two fundamental questions: human information-processing architecture functionally organised, and does its organisation support consciousness? We combine network science rigorous information-theoretic notion synergy delineate “synergistic global workspace”, comprising gateway regions that gather synergistic specialised modules across brain. This then integrated within workspace widely distributed via broadcaster regions. Through functional MRI analysis, show correspond brain’s default mode network, whereas broadcasters coincide with executive control network. Demonstrating empirical relevance our proposed for neural processing, loss consciousness due general anaesthesia or disorders corresponds diminished ability integrate information, which restored upon recovery. Thus, coincides breakdown integration work contributes conceptual reconciliation between prominent scientific theories consciousness, Global Neuronal Workspace Integrated Information Theory. Taken together, this provides new perspective on role resting-state networks architecture, while also advancing understanding supports through information.
Язык: Английский
Процитировано
39
Entropy, Год журнала: 2023, Номер 25(3), С. 449 - 449
Опубликована: Март 3, 2023
Originally conceived as a theory of consciousness, integrated information (IIT) provides theoretical framework intended to characterize the compositional causal that system, in its current state, specifies about itself. However, it remains be determined whether IIT consciousness is compatible with quantum mechanics microphysics. Here, we present an extension IIT’s latest formalism evaluate mechanism (φ) system subset discrete, finite-dimensional systems (e.g., logic gates). To end, translate recently developed, unique measure intrinsic into density matrix formulation and extend notion conditional independence accommodate entanglement. The nature analysis might shed some light on internal structure composite states operators cannot obtained using standard information-theoretical analysis. Finally, our results should inform arguments link between causation, physics from classical quantum.
Язык: Английский
Процитировано
13
Neuroscience of Consciousness, Год журнала: 2023, Номер 2023(1)
Опубликована: Янв. 1, 2023
This paper investigates the compatibility between theoretical framework of global neuronal workspace theory (GNWT) conscious processing and perturbational complexity index (PCI). Even if it has been introduced within a concurrent (i.e. Integrated Information Theory), PCI appears, in principle, compatible with main tenet GNWT, which is process that depends on long-range connection different cortical regions, more specifically amplification, propagation, integration brain signals. Notwithstanding this basic compatibility, number limited compatibilities apparent differences emerge. starts from description complexity, notion crucial for PCI, to then summary features tenets GNWT. Against background, text explores It concludes GNWT are fundamentally compatible, even though there some partial disagreements points further examine.
Язык: Английский
Процитировано
12