bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 7, 2024

Abstract Photosensitive Epilepsy (PE) is a neurological disorder characterized by seizures triggered harmful visual stimuli, such as flashing lights and high-contrast patterns. The mechanisms underlying PE remain poorly understood, to date, no computational model has captured the phenomena associated with this condition. Biologically detailed spiking networks trained for efficient prediction of natural scenes have been shown capture V1-like characteristics. Here, we show that these models display seizure-like activity in response stimuli while retaining healthy responses non-provocative when post-synaptic inhibitory connections are weakened. Notably, our adapted resembles motion tuning contrast gain excitatory V1 neurons mice optogenetically reduced activity. We offer testable predictions pathophysiology exploring how inhibition leads Finally, artificially injecting pulsating input current into units prevents restores baseline function. In summary, present offers new insights understand treat

Язык: Английский